Why does CAS 57-66-9 appear in more than one EU cosmetic annex?

A substance identified by CAS 57-66-9 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 57-66-9?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 57-66-9 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 57-66-9

Q: How do I use CAS 57-66-9 for compliance screening?

Cross-reference CAS 57-66-9 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 57-66-9 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 57-66-9

CAS 57-66-9PubChem CID 4911

Probenecid

Probenecid is a sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups. It has a role as a uricosuric drug. It is a member of benzoic acids and a sulfonamide. — ChEBI

IUPAC name: 4-(dipropylsulfamoyl)benzoic acid

Molecular formula: C13H19NO4S
Molecular weight: 285.36 g/mol
Exact mass: 285.10347926 Da
XLogP3: 3.2
Topological polar surface area: 83.1 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

BenemidProbenecid acidProbecidBenecidApurinaBenurylp-(Dipropylsulfamoyl)benzoic acidProbalan

16 more reported names

ProbenemidProlongineTubophanUricosidProbenSynergid RProbenecideProbenecidum4-[(dipropylamino)sulfonyl]benzoic acidProbenecida4-((Dipropylamino)sulfonyl)benzoic acidProbenateNCI-C560974-(Di-n-propylsulfamoyl)benzoesaeureBenzoic acid, p-(dipropylsulfamoyl)-4-(N,N-Dipropylsulfamoyl)benzoesaeure

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:8426
ChEMBL:CHEMBL897
EPA DTXSID:DTXSID9021188
PubMed:39481674
PubMed:39041788
PubMed:38761188
PubMed:38428544
PubMed:37352135
PubMed:35550413
PubMed:35114312
PubMed:35019195
PubMed:34135758
PubMed:33236189
PubMed:32305507
PubMed:32003934

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 57-66-9

1 total

Annex

Entry

161

Probenecid (INN)

200-344-3

How CAS 57-66-9 is used on this site

CAS 57-66-9 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 57-66-9 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 57-66-9 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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