Why does CAS 54-04-6 appear in more than one EU cosmetic annex?

A substance identified by CAS 54-04-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 54-04-6?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 54-04-6 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 54-04-6

Q: How do I use CAS 54-04-6 for compliance screening?

Cross-reference CAS 54-04-6 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 54-04-6 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

Check this CAS number Browse annexes

Chemical identity and properties

PubChem 2D chemical structure for CAS 54-04-6

CAS 54-04-6PubChem CID 4076

Mescaline

Mescaline is a phenethylamine alkaloid that is phenethylamine substituted at positions 3, 4 and 5 by methoxy groups. It has a role as a hallucinogen and a plant metabolite. It is a phenethylamine alkaloid, a primary amino compound and a member of methoxybenzenes. It is a conjugate base of a mescalinium. — ChEBI

IUPAC name: 2-(3,4,5-trimethoxyphenyl)ethanamine

Molecular formula: C11H17NO3
Molecular weight: 211.26 g/mol
Exact mass: 211.12084340 Da
XLogP3: 0.7
Topological polar surface area: 53.7 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Mescalin3,4,5-TrimethoxyphenethylamineMezcaline3,4,5-Trimethoxybenzeneethanamine3,4,5-TrimethoxyphenylethylamineBenzeneethanamine, 3,4,5-trimethoxy-NSC-30419CHEBI:28346

16 more reported names

RefChem:6005200-190-7TrimethoxyphenethylamineTmpeaMezcalinmescalinamezcalinaMeskalin2-(3,4,5-trimethoxy-phenyl)-ethylamineMesclineMezcline2-(3,4,5-Trimethoxyphenyl)ethylaminePhenethylamine, 3,4,5-trimethoxy-NSC 30419Ethane, 1-amino-2-(3,4,5-trimethoxyphenyl)-M (PSYCHEDELIC)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28346
ChEMBL:CHEMBL26687
EPA DTXSID:DTXSID80202303
PubMed:21366332
PubMed:21152030
PubMed:20716904
PubMed:18397574
PubMed:14516493
PubMed:12877591
PubMed:12822180
PubMed:12422935
PubMed:9301661
PubMed:9264312
PubMed:7365744
PubMed:7310924

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 54-04-6

1 total

Annex

Entry

222

3,4,5-Trimethoxyphenethylamine (Mescaline) and its salts

200-190-7

How CAS 54-04-6 is used on this site

CAS 54-04-6 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 54-04-6 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 54-04-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

Check this CAS number

Tools & next steps

Check your formula

Scan a full INCI list, then use CAS 54-04-6 to cross-check any supplier documents behind the matched substances.

INCI Checker

Browse annexes

Browse all EU cosmetic regulation annexes by category.

All annexes

Search by name

Search for INCI names, aliases or related identifiers that sit alongside CAS 54-04-6 in your documentation.