Why does CAS 526-36-3 appear in more than one EU cosmetic annex?

A substance identified by CAS 526-36-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 526-36-3?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 526-36-3 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 526-36-3

Q: How do I use CAS 526-36-3 for compliance screening?

Cross-reference CAS 526-36-3 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 526-36-3 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 526-36-3

CAS 526-36-3PubChem CID 5709

Xylometazoline

Xylometazoline is an alkylbenzene. — ChEBI

IUPAC name: 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole

Molecular formula: C16H24N2
Molecular weight: 244.37 g/mol
Exact mass: 244.193948774 Da
XLogP3: 3.2
Topological polar surface area: 24.4 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

XylomethazolineOtrivenXilometazolinaXylometazolinumBalminilWPY40FTH8K2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline1H-Imidazole, 2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydro-

16 more reported names

1H-Imidazole, 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-stasNasanOtrivin MentolNasentropfen ALNasenspray AL2-((4-tert-butyl-2,6-dimethylphenyl)methyl)-4,5-dihydro-1H-imidazoleNasenSpray ratiopharmNasenTropfen ratiopharmRefChem:580812-(4'-tert-butyl-2',6'-dimethylphenylmethyl)imidazolineR01AA07R01AB06S01GA03208-390-6Otrivin

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:10082
ChEMBL:CHEMBL312448
EPA DTXSID:DTXSID8046957
PubMed:36101495
PubMed:23120592
PubMed:22557753
PubMed:22557748
PubMed:22529429
PubMed:22459504
PubMed:22374848
PubMed:22287331
PubMed:22220172
PubMed:22209257
PubMed:22189346
PubMed:22144930

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 526-36-3

1 total

Annex

Entry

313

Xylometazoline (INN) and its salts

208-390-6

How CAS 526-36-3 is used on this site

CAS 526-36-3 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 526-36-3 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 526-36-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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