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CAS 1 record

CAS 501-30-4

CAS 501-30-4 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 501-30-4
CAS 501-30-4PubChem CID 3840

Kojic Acid

Kojic acid is a pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor, a NF-kappaB inhibitor, an Aspergillus metabolite, a skin lightening agent, an EC 1.10.3.1 (catechol oxidase) inhibitor, an EC 1.10.3.2 (laccase) inhibitor, an EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor and an EC 1.4.3.3 (D-amino-acid oxidase) inhibitor. It is a member of 4-pyranones, a primary alcohol and an enol. It derives from a hydride of a 4H-pyran. — ChEBI

IUPAC name
5-hydroxy-2-(hydroxymethyl)pyran-4-one
Molecular formula
C6H6O4
Molecular weight
142.11 g/mol
Exact mass
142.02660867 Da
XLogP3
-0.9
Topological polar surface area
66.8 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one5-Hydroxy-2-(hydroxymethyl)-4-pyrone5-Hydroxy-2-hydroxymethyl-4-pyrone4H-PYRAN-4-ONE, 5-HYDROXY-2-(HYDROXYMETHYL)-acido kojico2-Hydroxymethyl-5-hydroxy-gamma-pyrone2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-oneCHEBI:43572
16 more reported names
6K23F1TT52NSC-1942BeauteCleansing PasdsTurmericKojicSoapSurfree Kojic AcidCLEANSING PADSKojic Acid Dark SpotKojic Acid 0.6%Kojic Acid 4.4%RefChem:5934RET I NOLDeodorant Underarms Body SkinGZE Lemon Turmeric Kojic ScidSoapKojic Acid Turmeric Cleansing PadsCVC TURMERIC CLEANSING PASDS
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 501-30-4

1 total
Annex
III
Entry
375

Kojic Acid

5-Hydroxy-2-(hydroxymethyl)-4H-pyrane-4-one

From 1 February 2025 cosmetic products containing that substance and not complying with the conditions shall not be placed on the Union market. From 1 November 2025 cosmetic products containing that substance and not co…

EC
207-922-4
Max concentration

How CAS 501-30-4 is used on this site

CAS 501-30-4 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 501-30-4 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 501-30-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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