Why does CAS 50-18-0 appear in more than one EU cosmetic annex?

A substance identified by CAS 50-18-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 50-18-0?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 50-18-0 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 50-18-0

Q: How do I use CAS 50-18-0 for compliance screening?

Cross-reference CAS 50-18-0 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 50-18-0 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 50-18-0

CAS 50-18-0PubChem CID 2907

Cyclophosphamide

Cyclophosphamide is a phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom. It has a role as an alkylating agent, an antineoplastic agent, a xenobiotic, an immunosuppressive agent, an antirheumatic drug, a carcinogenic agent, an environmental contaminant and a drug allergen. It is a phosphorodiamide, an organochlorine compound and a nitrogen mustard. — ChEBI

IUPAC name: N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine

Molecular formula: C7H15Cl2N2O2P
Molecular weight: 261.08 g/mol
Exact mass: 260.0248201 Da
XLogP3: 0.6
Topological polar surface area: 41.6 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

CytoxanCyclophosphamidCyclophosphaneClafenEndoxanCyclophosphanCytophosphanProcytox

16 more reported names

SendoxanCyclophosphamidumClapheneCyclostinEndoxanaEndoxanalGenoxalMitoxanCyclophosphoramideEndoxan RCytophosphaneZyklophosphamidCyklofosfamid(RS)-CyclophosphamideCiclofosfamidaCyclophosphanum

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:4027
ChEMBL:CHEMBL88
EPA DTXSID:DTXSID5020364
PubMed:21318049
PubMed:18930809
PubMed:8697402
PubMed:2491747
PubMed:1987646

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 50-18-0

1 total

Annex

Entry

Cyclophosphamide (INN) and its salts

200-015-4

How CAS 50-18-0 is used on this site

CAS 50-18-0 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 50-18-0 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 50-18-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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