Why does CAS 497-76-7 appear in more than one EU cosmetic annex?

A substance identified by CAS 497-76-7 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

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Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 497-76-7 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 497-76-7

Q: How do I use CAS 497-76-7 for compliance screening?

Cross-reference CAS 497-76-7 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 497-76-7 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 497-76-7

CAS 497-76-7PubChem CID 440936

Arbutin

Hydroquinone O-beta-D-glucopyranoside is a monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage. It has a role as a plant metabolite and an Escherichia coli metabolite. It is a beta-D-glucoside and a monosaccharide derivative. It is functionally related to a hydroquinone. — ChEBI

IUPAC name: (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol

Molecular formula: C12H16O7
Molecular weight: 272.25 g/mol
Exact mass: 272.08960285 Da
XLogP3: -0.7
Topological polar surface area: 120.0 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 7
Covalent units: 1
Defined stereocentres: 5

Also known as

ArbutosideUrsinbeta-ArbutinUvasolp-Hydroxyphenyl beta-D-glucosideArbutinum4-Hydroxyphenyl-beta-D-glucopyranosideHydroquinone-O-beta-D-glucopyranoside

16 more reported names

Hydroquinone glucoseHydroquinone-beta-D-glucopyranosidehydroquinone O-beta-D-glucopyranosideC5INA23HXFCHEBI:18305NSC-4036beta-D-Glucopyranoside, 4-hydroxyphenylBright Boost CreamDRUGGIST Creamskin brightening creamHYDRO HRefChem:28025bright moisturizing creamDRUGGIST Whitening CreamDRUGGIST Brightening creamVitamin C Brightening Cream

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:18305
ChEMBL:CHEMBL232202
EPA DTXSID:DTXSID7040152
PubMed:40319997
PubMed:37783241
PubMed:36284482
PubMed:34346143
PubMed:32757845
PubMed:29360751
PubMed:24189417
PubMed:22705713
PubMed:21872416
PubMed:21071833
PubMed:19387580
PubMed:17420575

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 497-76-7

1 total

Annex

III

Entry

378

Arbutin

4-Hydroxyphenyl-beta-D-glucopyranoside

Hydroquinone levels shall remain as low as possible in formulations containing alpha-Arbutin and shall not be higher than the unavoidable trace level. From 1 February 2025 cosmetic products containing that substance an…

207-850-3

Max concentration

How CAS 497-76-7 is used on this site

CAS 497-76-7 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 497-76-7 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 497-76-7 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Chemical identity and properties

Arbutin

Records for CAS 497-76-7

Arbutin

How CAS 497-76-7 is used on this site

Frequently asked questions

Why does CAS 497-76-7 appear in more than one annex?

How do I use CAS 497-76-7 for compliance screening?

What is the difference between a CAS number and an EC number?

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