Why does CAS 495-54-5 appear in more than one EU cosmetic annex?

A substance identified by CAS 495-54-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 495-54-5?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 495-54-5 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 495-54-5

Q: How do I use CAS 495-54-5 for compliance screening?

Cross-reference CAS 495-54-5 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 495-54-5 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 495-54-5

CAS 495-54-5PubChem CID 10317

2,4-Diaminoazobenzene

Chrysoidine free base is a member of azobenzenes. — ChEBI

IUPAC name: 4-phenyldiazenylbenzene-1,3-diamine

Molecular formula: C12H12N4
Molecular weight: 212.25 g/mol
Exact mass: 212.106196400 Da
XLogP3: 2.3
Topological polar surface area: 76.8 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

Solvent Orange 3Chrysoidine Y Base NewAzobenzene-2,4-diamine2,4-Diaminoazobenzenm-Phenylenediamine, 4-(phenylazo)-4-(Phenylazo)-1,3-phenylenediamineNSC 32732,4-Diaminoazobenzen [Czech]

16 more reported names

Chrysoidine (free base)Chrysoidin AChrysoidine (Salt/Mix)C.I. Basic Orange 2 (Salt/Mix)RefChem:82274IWRVPXDHSLTIOC-FOCLMDBBSA-NChrysoidine free baseChrysoidine Y Base1,3-Benzenediamine, 4-(phenylazo)-Chrysoidine BaseGrasan chrysoidineAzohelFat Brown GGChrysoidine Base AC.I. Solvent Orange 3Waxoline Orange Y

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:34640
ChEMBL:CHEMBL1623562
ChEMBL:CHEMBL1739417
EPA DTXSID:DTXSID4043856
EPA DTXSID:DTXSID60859410
EPA DTXSID:DTXSID801256557
PubMed:21849932
PubMed:21632023
PubMed:21574405
PubMed:21277579
PubMed:20698269
PubMed:20426818
PubMed:20132946
PubMed:20082281
PubMed:19897408
PubMed:19568449
PubMed:19385715
PubMed:18433996

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 495-54-5

1 total

Annex

Entry

1293

m-Phenylenediamine, 4-(phenylazo)-, and its salts, when used as a substance in hair dye products

207-803-7

CMR

How CAS 495-54-5 is used on this site

CAS 495-54-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 495-54-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 495-54-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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