Why does CAS 492-80-8 appear in more than one EU cosmetic annex?

A substance identified by CAS 492-80-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 492-80-8?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 492-80-8 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 492-80-8

Q: How do I use CAS 492-80-8 for compliance screening?

Cross-reference CAS 492-80-8 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 492-80-8 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 492-80-8

CAS 492-80-8PubChem CID 10298

Solvent Yellow 34

Auramine O free base is a member of the class of imines that is benzophenone imine carrying two dimethylamino substituents at positions 4 and 4'. The hydrochloride salt is the biological stain 'auramine O'. It has a role as a fluorochrome and a histological dye. It is an imine, a substituted aniline and a tertiary amino compound. It is a conjugate base of an auramine O(1+). — ChEBI

IUPAC name: 4-[4-(dimethylamino)benzenecarboximidoyl]-N,N-dimethylaniline

Molecular formula: C17H21N3
Molecular weight: 267.37 g/mol
Exact mass: 267.173547683 Da
XLogP3: 4.0
Topological polar surface area: 30.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

AURAMINEYellow pyoctanineGlauramineAuramine baseAuramine O baseAuramine N baseAuramine OAFApyonine auramine base

16 more reported names

Auramine SSAuramine (free base)C.I. Solvent Yellow 34Waxoline Yellow O4,4'-DimethylaminobenzophenonimideCI Solvent Yellow 34CI Basic Yellow 2, free baseBis(p-dimethylaminophenyl)methyleneimineTetramethyl-p-diamino-imido-benzophenone4,4'-(Imidocarbonyl)bis(N,N-dimethylaniline)4,4'-Carbonimidoylbis(N,N-dimethylaniline)C.I. 41000BCI 41000BAniline, 4,4'-imidocarbonylbis(N,N-dimethyl-4,4'-Carbonimidoylbis(N,N-dimethylbenzenamine)Aniline, 4,4'-(imidocarbonyl)bis(N,N-dimethyl-

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:51874
ChEMBL:CHEMBL1626329
EPA DTXSID:DTXSID7043821
PubMed:22978578
PubMed:22966426
PubMed:22693637
PubMed:22675566
PubMed:22666578
PubMed:22640455
PubMed:22615839
PubMed:22563151
PubMed:22558436
PubMed:22474177
PubMed:22453608
PubMed:22412840

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 492-80-8

1 total

Annex

Entry

1067

4,4'-Carbonimidoylbis[N,N-dimethylaniline] and its salts

207-762-5

CMR

How CAS 492-80-8 is used on this site

CAS 492-80-8 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 492-80-8 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 492-80-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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