Why does CAS 483-17-0 appear in more than one EU cosmetic annex?

A substance identified by CAS 483-17-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 483-17-0?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 483-17-0 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 483-17-0

Q: How do I use CAS 483-17-0 for compliance screening?

Cross-reference CAS 483-17-0 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 483-17-0 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 483-17-0

CAS 483-17-0PubChem CID 442195

Cephaeline

Cephaeline is a pyridoisoquinoline comprising emetam having a hydroxy group at the 6'-position and methoxy substituents at the 7'-, 10- and 11-positions. It is a conjugate base of a cephaeline(2+). It derives from a hydride of an emetan. — ChEBI

IUPAC name: (1R)-1-[[(2S,3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-ol

Molecular formula: C28H38N2O4
Molecular weight: 466.6 g/mol
Exact mass: 466.28315770 Da
XLogP3: 4.4
Topological polar surface area: 63.2 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 4

Also known as

Cephaelin(-)-CephaelineCHEBI:3533cephalinedesmethyl-emetine(1R)-1-(((2S,3R,11bS)-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo(a)quinolizin-2-yl)methyl)-7-methoxy-1,2,3,4-tetrahydroisoquinolin-6-olRefChem:124364207-591-6

16 more reported names

Cepheline7',10,11-Trimethoxyemetan-6'-olDihydropsychotrine5483-17-0CephaelinelUNII-QA971541A1DTGZHCFJNDAHEN-OZEXIGSWSA-NC28H38N2O4Emetan-6'-ol, 7',10,11-trimethoxy-EINECS 207-591-66'-O-demethylemetineCEPHAELINE [MI]Prestwick0_000428Prestwick1_000428Prestwick2_000428Prestwick3_000428

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:3533
ChEMBL:CHEMBL255708
EPA DTXSID:DTXSID501016520
PubMed:23074898
PubMed:22860455
PubMed:22654404
PubMed:21941891
PubMed:21637610
PubMed:21423357
PubMed:21228475
PubMed:20495341
PubMed:20298468
PubMed:20116850
PubMed:20061395
PubMed:19227966

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 483-17-0

1 total

Annex

Entry

Cephaeline and its salts

207-591-6

How CAS 483-17-0 is used on this site

CAS 483-17-0 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 483-17-0 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 483-17-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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