Why does CAS 4482-25-1 appear in more than one EU cosmetic annex?

A substance identified by CAS 4482-25-1 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 4482-25-1?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 4482-25-1 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 4482-25-1

Q: How do I use CAS 4482-25-1 for compliance screening?

Cross-reference CAS 4482-25-1 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 4482-25-1 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 4482-25-1

CAS 4482-25-1PubChem CID 24674

Bismarck Brown R Base

IUPAC name: 4-[[3-[(2,4-diamino-5-methylphenyl)diazenyl]-4-methylphenyl]diazenyl]-6-methylbenzene-1,3-diamine

Molecular formula: C21H24N8
Molecular weight: 388.5 g/mol
Exact mass: 388.21239280 Da
XLogP3: 3.8
Topological polar surface area: 154.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 8
Covalent units: 1
Defined stereocentres: 0

Also known as

5,5'-[(4-methyl-1,3-phenylene)bis(azo)]bis[toluene-2,4-diamine]5,5'-((4-Methyl-1,3-phenylene)bis(azo))bis(toluene-2,4-diamine)RefChem:569462Bismarck Brown X BaseBismarck Brown G BaseBismarck Brown Base NSBismarck Brown RX BaseBismarck Brown TSS Base

16 more reported names

Brasilazina Brown R Base1,3-Benzenediamine, 4,4'-[(4-methyl-1,3-phenylene)bis(azo)]bis[6-methyl-357RPV4TE1NSC-477221,3-Benzenediamine, 4,4'-((4-methyl-1,3-phenylene)bis(azo))bis(6-methyl-Solvent Brown 121,3-Benzenediamine,4,4'-[(4-methyl-1,3-phenylene)bis(azo)]bis[6-methyl-1,3-Benzenediamine, 4,4'-((4-methyl-1,3-phenylene)bis(2,1-diazenediyl))bis(6-methyl-6,6'-((1E,1'E)-(4-Methyl-1,3-phenylene)bis(diazene-2,1-diyl))bis(4-methylbenzene-1,3-diamine)UNII-357RPV4TE1solvent brown1,3-Benzenediamine, 4,4'-[(4-methyl-1,3-phenylene)bis(2,1-diazenediyl)]bis[6-methyl-4-[[3-[(2,4-diamino-5-methylphenyl)diazenyl]-4-methylphenyl]diazenyl]-6-methylbenzene-1,3-diamine;dihydrochloridecid_24674BASIC BROWN 4 FREE BASEC.I. SOLVENT BROWN 12

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL1602553
ChEMBL:CHEMBL1864168
EPA DTXSID:DTXSID5063491

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 4482-25-1

1 total

Annex

Entry

1296

4,4'-[(4-Methyl-1,3-phenylene)bis(azo)]bis[6-methyl-1,3-benzenediamine] (Basic Brown 4) and its salts, when used as a substance in hair dye products

224-764-1

How CAS 4482-25-1 is used on this site

CAS 4482-25-1 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 4482-25-1 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 4482-25-1 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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