Why does CAS 3536-49-0 appear in more than one EU cosmetic annex?

A substance identified by CAS 3536-49-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 3536-49-0?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 3536-49-0 to screen it directly, then review every linked annex record and supplier document.

CAS 2 records

CAS 3536-49-0

Q: How do I use CAS 3536-49-0 for compliance screening?

Cross-reference CAS 3536-49-0 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 3536-49-0 matches 2 EU annex records across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 3536-49-0

CAS 3536-49-0PubChem CID 77073

Acid Blue 3

C.I. Acid Blue 3 is a diarylmethane. — ChEBI

IUPAC name: calcium bis(4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]-6-hydroxybenzene-1,3-disulfonate)

Molecular formula: C54H62CaN4O14S4
Molecular weight: 1159.4 g/mol
Exact mass: 1158.2771282 Da
Topological polar surface area: 315.0 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 16
Covalent units: 3
Defined stereocentres: 0

Also known as

Patent Blue VCarmine Blue VMerantine Blue VSolar Pure Blue VXSchultz No. 826Patent Blue V and LMitsui Acid Pure Blue VXNew Patent Blue A-CE Extra

16 more reported names

New Patent Blue Extra Pure ANSC 5010EINECS 222-573-8Patent Blue 5NSC 75430Alphazurine 2 G (C.I. 42051)8QE473DV1ZC.I. 712CI 42051C.I. 42051E 131CI FOOD BLUE 5ARIAVIT PATENT BLUE VPATENT BLUE V [FCC]m-Hydroxytetraethyldiaminotriphenylcarbinol anhydride disulfonic acid calcium saltINS NO.131

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:187511
EPA DTXSID:DTXSID00873918

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 3536-49-0

2 total

Annex

Entry

1356

Ethanaminium, N-(4-((4-diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-N-ethyl-, hydroxide, inner salt, calcium salt (…

222-573-8

Annex

Entry

CI 42051 /ACID BLUE 3

Ethanaminium, N-(4-((4-(diethylamino)phenyl)(5-hydroxy-2,4-disulfophenyl)methylene)-2,5-cyclohexadien-1-ylidene)-N-ethylhydroxide, inner salt, calcium salt (2:1) and its insoluble barium, strontium and zirconium lakes, …

Purity criteria as set out in Commission Directive 95/45/EC (E 131)

222-573-8

How CAS 3536-49-0 is used on this site

CAS 3536-49-0 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 2 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 3536-49-0 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 3536-49-0 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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