Why does CAS 302-27-2 appear in more than one EU cosmetic annex?

A substance identified by CAS 302-27-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 302-27-2?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 302-27-2 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 302-27-2

Q: How do I use CAS 302-27-2 for compliance screening?

Cross-reference CAS 302-27-2 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 302-27-2 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 302-27-2

CAS 302-27-2PubChem CID 245005

Aconitine

Aconitine is a diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and benzoate groups at the 8- and 14-positions respectively. It is functionally related to an aconitane. — ChEBI

IUPAC name: [(1S,2R,3R,4R,5R,6S,7S,8R,9R,13R,14R,16S,17S,18R)-8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl] benzoate

Molecular formula: C34H47NO11
Molecular weight: 645.7 g/mol
Exact mass: 645.31491132 Da
XLogP3: 0.3
Topological polar surface area: 153.0 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 12
Covalent units: 1
Defined stereocentres: 14

Also known as

CHEBI:2430AcetylbenzoylaconineAconitinumAcetylbenzoyl aconineAconitin cristallisat20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diyl 8-acetate 14-benzoateAcetylbenzoyl-aconineAconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-benzoate, (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-

14 more reported names

RefChem:26354(1Alpha,3Alpha,6Alpha,14Alpha,15Alpha,16Beta)-20-Ethyl-1,6,16-Trimethoxy-4-(Methoxymethyl)Aconitane-3,8,13,14,15-Pentol 8-Acetate 14-Benzoate206-121-7(8-acetyloxy-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo(7.7.2.12,5.01,10.03,8.013,17)nonadecan-4-yl) benzoateNSC-56464NSC-759627X8YN71D5WCC34H47NO1116-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoateb]azocin-8-yl benzoateEpitope ID:2133981GTPL2617XFSBVAOIAHNAPC-XTHSEXKGSA-NNCI60_004380

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:2430
ChEMBL:CHEMBL1979562
PubMed:37506855
PubMed:35101544
PubMed:33945864
PubMed:33236894
PubMed:32598336
PubMed:32234357
PubMed:31975431
PubMed:31499053
PubMed:30639578
PubMed:30303438
PubMed:28193520
PubMed:28099878

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 302-27-2

1 total

Annex

Entry

Aconitine (principal alkaloid of Aconitum napellus L.) and its salts

206-121-7

How CAS 302-27-2 is used on this site

CAS 302-27-2 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 302-27-2 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 302-27-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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