Why does CAS 2682-20-4 appear in more than one EU cosmetic annex?

A substance identified by CAS 2682-20-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 2682-20-4?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 2682-20-4 to screen it directly, then review every linked annex record and supplier document.

CAS 2 records

CAS 2682-20-4

Q: How do I use CAS 2682-20-4 for compliance screening?

Cross-reference CAS 2682-20-4 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 2682-20-4 matches 2 EU annex records across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 2682-20-4

CAS 2682-20-4PubChem CID 39800

Methylisothiazolinone

Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. It is a powerful biocide and preservative and is the minor active ingredient in the commercial product KathonTM. It has a role as an antimicrobial agent, an antifungal agent and an antifouling biocide. — ChEBI

IUPAC name: 2-methyl-1,2-thiazol-3-one

Molecular formula: C4H5NOS
Molecular weight: 115.16 g/mol
Exact mass: 115.00918496 Da
XLogP3: 0.0
Topological polar surface area: 45.6 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

2-Methyl-4-isothiazolin-3-one2-Methyl-3(2H)-isothiazolone2-Methyl-4-isothiazoline-3-oneN-methylisothiazolone3(2H)-Isothiazolone, 2-methyl-2-methyl-3-isothiazolonen-methylisothiazolin-3-oneNeolone 950

16 more reported names

2-methyl-1,2-thiazol-3(2H)-one229D0E1QFA2-Methyl-4-isothiazoline-3-ketoneCHEBI:53620methyl-isothiazolinonemethylisothiazolidinoneRefChem:158243220-239-6methylisothiazolone2-methylisothiazol-3(2h)-one2-METHYL-2H-ISOTHIAZOL-3-ONEMITNeoloneN-Methyl-3-oxodihydroisothiazole2-Methyl-4-isothiazolin-3-one (MI)Kordek 50

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:53620
ChEMBL:CHEMBL1620780
EPA DTXSID:DTXSID2034259
PubMed:22568846
PubMed:22568842
PubMed:22500724
PubMed:22345776
PubMed:22345774
PubMed:22245758
PubMed:21901563
PubMed:21827510
PubMed:21777214
PubMed:21728892
PubMed:21692811
PubMed:21535006

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 2682-20-4

2 total

Annex

Entry

METHYLISOTHIAZOLINONE

2-Methyl-2H-isothiazol-3-one

220-239-6

Max concentration

How CAS 2682-20-4 is used on this site

CAS 2682-20-4 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 2 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 2682-20-4 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 2682-20-4 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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