Why does CAS 2602-46-2 appear in more than one EU cosmetic annex?

A substance identified by CAS 2602-46-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 2602-46-2?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 2602-46-2 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 2602-46-2

Q: How do I use CAS 2602-46-2 for compliance screening?

Cross-reference CAS 2602-46-2 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 2602-46-2 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 2602-46-2

CAS 2602-46-2PubChem CID 17449

C.I. Direct Blue 6

Direct Blue 6 (Technical Grade) can cause cancer according to an independent committee of scientific and health experts. — California Office of Environmental Health Hazard Assessment (OEHHA)

IUPAC name: tetrasodium;5-amino-3-[[4-[4-[(8-amino-1-hydroxy-3,6-disulfonatonaphthalen-2-yl)diazenyl]phenyl]phenyl]diazenyl]-4-hydroxynaphthalene-2,7-disulfonate

Molecular formula: C32H20N6Na4O14S4
Molecular weight: 932.8 g/mol
Exact mass: 931.9511112 Da
Topological polar surface area: 404.0 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 20
Covalent units: 5
Defined stereocentres: 0

Also known as

DIRECT BLUE 6Airedale Blue 2BDDirect Sky Blue KDirect Blue 2BIndigo Blue 2BKayaku directDiamine Blue BBDirect Blue 6 (technical grade)

16 more reported names

Chlorazol Blue BDirect Blue ADirect Blue BBDirect Blue GSDirect Blue KNippon Blue BBAzocard Blue 2BAzomine Blue 2BBenzo Blue GSDiamine Blue 2BDiazine Blue 2BDiphenyl Blue KFFenamin Blue 2BFixanol Blue 2BNiagara Blue 2BAmanil Blue 2BX

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID2020185

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 2602-46-2

1 total

Annex

Entry

988

Tetrasodium 3,3'-[[1,1'-biphenyl]-4,4'-diylbis(azo)]bis[5-amino-4-hydroxynaphthalene-2,7-disulphonate]

220-012-1

CMR

How CAS 2602-46-2 is used on this site

CAS 2602-46-2 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 2602-46-2 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 2602-46-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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