Why does CAS 21245-02-3 appear in more than one EU cosmetic annex?

A substance identified by CAS 21245-02-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 21245-02-3?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 21245-02-3 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 21245-02-3

Q: How do I use CAS 21245-02-3 for compliance screening?

Cross-reference CAS 21245-02-3 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 21245-02-3 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 21245-02-3

CAS 21245-02-3PubChem CID 30541

Padimate-O

Padimate O is a benzoate ester. — ChEBI

IUPAC name: 2-ethylhexyl 4-(dimethylamino)benzoate

Molecular formula: C17H27NO2
Molecular weight: 277.4 g/mol
Exact mass: 277.204179104 Da
XLogP3: 5.0
Topological polar surface area: 29.5 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

2-ethylhexyl-p-dimethylaminobenzoateRefChem:566624-N,N'-dimethylamino-benzoic acid, 2-ethylhexyl esterPadimate O2-ETHYLHEXYL 4-DIMETHYLAMINOBENZOATEOctyl dimethyl PABAEscalol 507Eusolex 6007

16 more reported names

Arlatone UVB4-(Dimethylamino)benzoic acid 2-ethylhexyl esterBenzoic acid, 4-(dimethylamino)-, 2-ethylhexyl ester2-Ethylhexyl p-dimethylaminobenzoateUvasorb dmo2-Ethylhexyl-4-dimethylaminobenzoate2-Ethylhexyl p-(dimethylamino)benzoateETHYLHEXYL DIMETHYL PABA2-Ethylhexyl-p-dimethyl-aminobenzoateRadiacare Lip BalmCAS-21245-02-3Octyl dimethyl p-aminobenzoateCaraloe Snow & Sun Lip BalmPamimate oHSDB 7169EINECS 244-289-3

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:135932
ChEMBL:CHEMBL1323699
EPA DTXSID:DTXSID7029320
PubMed:32889307
PubMed:28927721
PubMed:21847975
PubMed:20652544
PubMed:19768642
PubMed:18486139
PubMed:17646969
PubMed:17002521
PubMed:15499924
PubMed:15291305
PubMed:10477339

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 21245-02-3

1 total

Annex

Entry

ETHYLHEXYL DIMETHYL PABA

2-Ethylhexyl 4-(dimethylamino)benzoate / Padimate O (USAN:BAN)

244-289-3

Max concentration

How CAS 21245-02-3 is used on this site

CAS 21245-02-3 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 21245-02-3 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 21245-02-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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