Why does CAS 16867-03-1 appear in more than one EU cosmetic annex?

A substance identified by CAS 16867-03-1 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 16867-03-1?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 16867-03-1 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 16867-03-1

Q: How do I use CAS 16867-03-1 for compliance screening?

Cross-reference CAS 16867-03-1 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 16867-03-1 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 16867-03-1

CAS 16867-03-1PubChem CID 28114

2-Amino-3-Hydroxypyridine

2-amino-3-hydroxypyridine is a monohydroxypyridine and an aminopyridine. — ChEBI

IUPAC name: 2-aminopyridin-3-ol

Molecular formula: C5H6N2O
Molecular weight: 110.11 g/mol
Exact mass: 110.048012819 Da
XLogP3: 0.1
Topological polar surface area: 59.1 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

2-Amino-3-pyridinol3-Pyridinol, 2-amino-3-Hydroxy-2-pyridinamine3-HYDROXY-2-AMINOPYRIDINE3-Pyridinol, 2-aminoP8740PEW4BJAROCOL 2A3HPRODOL 2A3PYR

16 more reported names

NSC-136806RefChem:85129240-886-82-amino-pyridin-3-ol2-Amino-3-pyridolPaliperidone Impurity 252-amino-3-hydroxy-pyridine2-AMINO-3-HYDROXY PYRIDINEUNII-P8740PEW4BEINECS 240-886-8NSC 136806AI3-610612-amino-3hydroxypyridine2-amino-3 -hydroxypyridineBMTSZVZQNMNPCT-UHFFFAOYSA-CHEBI:195501

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:195501
ChEMBL:CHEMBL4777856
EPA DTXSID:DTXSID50168588
PubMed:31967339
PubMed:22447516
PubMed:22059053
PubMed:21676646
PubMed:21582665
PubMed:20638329
PubMed:19185533
PubMed:18585252
PubMed:18414586
PubMed:16533399

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 16867-03-1

1 total

Annex

III

Entry

211

2-AMINO-3-HYDROXYPYRIDINE

2-Aminopyridin-3-ol; 2-Amino-3-Hydroxypyridine

(a) To be printed on the label: The mixing ratio. “Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘b…

240-886-8

How CAS 16867-03-1 is used on this site

CAS 16867-03-1 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 16867-03-1 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 16867-03-1 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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