Why does CAS 14816-18-3 appear in more than one EU cosmetic annex?

A substance identified by CAS 14816-18-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 14816-18-3?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 14816-18-3 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 14816-18-3

Q: How do I use CAS 14816-18-3 for compliance screening?

Cross-reference CAS 14816-18-3 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 14816-18-3 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 14816-18-3

CAS 14816-18-3PubChem CID 26927

Phoxim

Phoxim is a synthetic organophosphate acetylcholinesterase inhibitor that is used as a pesticide. It is characterized as a yellow liquid, and exposure occurs by inhalation, ingestion, or contact. — NCI Thesaurus (NCIt)

IUPAC name: N-diethoxyphosphinothioyloxybenzenecarboximidoyl cyanide

Molecular formula: C12H15N2O3PS
Molecular weight: 298.30 g/mol
Exact mass: 298.05410052 Da
XLogP3: 4.4
Topological polar surface area: 95.9 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 6
Covalent units: 1
Defined stereocentres: 0

Also known as

BaythionPhoximeSebacil (insecticide)6F5V775VPOBAYER-9053Bay-77488BAY 77488Phoxin

16 more reported names

Phenylglyoxylnitrile oxime O,O-diethyl phosphorothioateO,O-Diethyl-alpha-cyanobenzylidineaminooxyphosphonothiateCHEBI:38812Sebacil Pour-onRefChem:863020phenylglyoxylonitrile oxime O,O-diethylphosphorothioate238-887-3alpha-(((Diethoxyphosphinothioyl)oxy)imino)benzeneacetonitrileBAYER 9053O-((cyano(phenyl)methylidene)amino) O,O-diethyl phosphorothioateValexonVolatonPhoxim-d5 (deuterated)PHOXIM [INN]PHOXIM [ISO]PHOXIM [MI]

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID8034324
PubMed:22854274
PubMed:22682359
PubMed:22666113
PubMed:22467368
PubMed:22452950
PubMed:22420260
PubMed:22363736
PubMed:22329773
PubMed:22247687
PubMed:22038851
PubMed:21762497
PubMed:21744158

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 14816-18-3

1 total

Annex

Entry

1410

Phoxim (ISO); a-(diethoxy-phosphinothioylimino) phenylacetonitrile

238-887-3

CMR

How CAS 14816-18-3 is used on this site

CAS 14816-18-3 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 14816-18-3 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 14816-18-3 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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