Why does CAS 147-20-6 appear in more than one EU cosmetic annex?

A substance identified by CAS 147-20-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 147-20-6?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 147-20-6 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 147-20-6

Q: How do I use CAS 147-20-6 for compliance screening?

Cross-reference CAS 147-20-6 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 147-20-6 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 147-20-6

CAS 147-20-6PubChem CID 3103

Diphenylpyraline

Diphenylpyraline is a member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold. It has a role as a H1-receptor antagonist and a cholinergic antagonist. It is a member of piperidines and a tertiary amine. — ChEBI

IUPAC name: 4-benzhydryloxy-1-methylpiperidine

Molecular formula: C19H23NO
Molecular weight: 281.4 g/mol
Exact mass: 281.177964357 Da
XLogP3: 3.9
Topological polar surface area: 12.5 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

LyssipollMepibenNeargal4-(Benzhydryloxy)-1-methylpiperidine4-(Diphenylmethoxy)-1-methylpiperidineDiphenylpyralamineAllergenDifenilpiralina

16 more reported names

DiphenylpyralinumAN 10411-Methyl-4-piperidyl benzhydryl ether4-(benzhydryloxy)-N-methylpiperidine1-methyl-4-hydroxypiperidine benzhydryl ether4-DIPHENYLMETHOXY-1-METHYLPIPERIDINECHEBI:59788RefChem:588945CHEBI:50904R06AA07205-686-7DiphenylpyrileneBelfeneDayfenHistynDiphenylpyraline (INN)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:59788
ChEMBL:CHEMBL1492
EPA DTXSID:DTXSID3022952
PubMed:22445882
PubMed:22364032
PubMed:22291486
PubMed:21818443
PubMed:19574011
PubMed:19472275
PubMed:19231896
PubMed:18977145
PubMed:18273383
PubMed:17714832
PubMed:16419026
PubMed:15627433

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 147-20-6

1 total

Annex

Entry

154

Diphenylpyraline (INN) and its salts

205-686-7

How CAS 147-20-6 is used on this site

CAS 147-20-6 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 147-20-6 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 147-20-6 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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