Why does CAS 140-65-8 appear in more than one EU cosmetic annex?

A substance identified by CAS 140-65-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 140-65-8?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 140-65-8 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 140-65-8

Q: How do I use CAS 140-65-8 for compliance screening?

Cross-reference CAS 140-65-8 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 140-65-8 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

Check this CAS number Browse annexes

Chemical identity and properties

PubChem 2D chemical structure for CAS 140-65-8

CAS 140-65-8PubChem CID 4886

Pramoxine

Pramocaine is a member of the class of morpholines that is morpholine substituted at the nitrogen atom by a 3-(4-butoxyphenoxy)propyl group. It has a role as a local anaesthetic. It is an aromatic ether and a member of morpholines. — ChEBI

IUPAC name: 4-[3-(4-butoxyphenoxy)propyl]morpholine

Molecular formula: C17H27NO3
Molecular weight: 293.4 g/mol
Exact mass: 293.19909372 Da
XLogP3: 3.1
Topological polar surface area: 30.9 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

PramocaineProxazocainpramocainumPramocaina4-(3-(p-Butoxyphenoxy)propyl)morpholinep-Butoxyphenyl gamma-morpholinopropyl ethergamma-Morpholinopropyl 4-n-butoxyphenyl ether4-(3-(4-butoxyphenoxy)propyl)morpholine

16 more reported names

CHEBI:8357068X84E056RefChem:55901C05AD07D04AB07205-425-7TronopthaneMorpholine, 4-(3-(p-butoxyphenoxy)propyl)-Pramocaine (INN)PRAMOCAINE [INN]Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-Pramocaine [INN:BAN]Pramocainum [INN-Latin]Pramocaina [INN-Spanish]EINECS 205-425-7BRN 0239059

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:8357
ChEMBL:CHEMBL1198
EPA DTXSID:DTXSID8040692
PubMed:22110329
PubMed:20616894
PubMed:19956587
PubMed:18821119
PubMed:18541107
PubMed:17436138
PubMed:17244091
PubMed:16856675
PubMed:16595565
PubMed:16416626
PubMed:16381427
PubMed:15274290

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 140-65-8

1 total

Annex

Entry

405

Pramocaine (INN)

205-425-7

How CAS 140-65-8 is used on this site

CAS 140-65-8 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 140-65-8 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 140-65-8 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

Check this CAS number

Tools & next steps

Check your formula

Scan a full INCI list, then use CAS 140-65-8 to cross-check any supplier documents behind the matched substances.

INCI Checker

Browse annexes

Browse all EU cosmetic regulation annexes by category.

All annexes

Search by name

Search for INCI names, aliases or related identifiers that sit alongside CAS 140-65-8 in your documentation.