CAS 116-53-0PubChem CID 8314
2-Methylbutanoic Acid
2-methylbutyric acid is a methylbutyric acid comprising a butyric acid core carrying a 2-methyl substituent. Produced from amino acid leucine during nutrient starvation in bacteria. It has a role as a bacterial metabolite and a human metabolite. It is a conjugate acid of a 2-methylbutyrate. — ChEBI
- IUPAC name
- 2-methylbutanoic acid
- Molecular formula
- C5H10O2
- Molecular weight
- 102.13 g/mol
- Exact mass
- 102.068079557 Da
- XLogP3
- 1.2
- Topological polar surface area
- 37.3 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
2-METHYLBUTYRIC ACIDDL-2-Methylbutyric acidButanoic acid, 2-methyl-Ethylmethylacetic acidMethylethylacetic acid2-Methybutyric acidalpha-Methylbutyric acidFEMA No. 2695
16 more reported names
PX7ZNN5GXKNSC-7304CHEBI:37070RefChem:910087204-145-2209-982-7Methylbutyric acid2-Methyl butyric acid600-07-7Active valeric acidButyric acid, 2-methyl-(+/-)-2-Methylbutyric acid2-methyl-butanoic acidalpha-methyl butyric AcidNSC 73042-methyl-butyric acid
External database identifiers
- ChEBI:CHEBI:37070
- ChEMBL:CHEMBL1160012
- EPA DTXSID:DTXSID5021621
- PubMed:22967964
- PubMed:22807836
- PubMed:22674272
- PubMed:22579985
- PubMed:22253706
- PubMed:22102402
- PubMed:22096324
- PubMed:22083912
- PubMed:21847343
- PubMed:21738412
- PubMed:21735899
- PubMed:21667308
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match8314
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 176.00 to 177.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 176 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Density: 0.932-0.936 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- LogP: 1.18 Source: Human Metabolome Database (HMDB)
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Physical Description: colourless to pale yellow liquid Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: 1.404-1.408 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: 45 mg/mL at 20 °C Source: Human Metabolome Database (HMDB)
- Solubility: 1 ml in 1 ml 95% alcohol (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1864) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (99.8%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (99.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H314 (> 99.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (83.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P260, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1864 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 1864 reports by companies.; There are 19 notifications provided by 1863 of 1864 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H290 (100%): May be corrosive to metals [Warning Corrosive to Metals]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P234, P260, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P390, P405, P406, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 89 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Industry Uses: Solvent; Fuel agents; Intermediate Source: EPA Chemical Data Reporting (CDR)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.