
3,3,5-Trimethylcyclohexanol
3,3,5-trimethylcyclohexanol is a secondary alcohol that is cyclohexanol substituted by two methyl groups at the 3-position and one methyl group at the 5-position. It exhibits inhibitory activity against HMG-CoA reductase ( EC 1.1.1.34/EC 1.1.1.88). It has a role as an EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor. It is a member of cyclohexanols and a secondary alcohol. — ChEBI
- IUPAC name
- 3,3,5-trimethylcyclohexan-1-ol
- Molecular formula
- C9H18O
- Molecular weight
- 142.24 g/mol
- Exact mass
- 142.135765193 Da
- XLogP3
- 2.6
- Topological polar surface area
- 20.2 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 1
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:59065
- ChEMBL:CHEMBL3186608
- EPA DTXSID:DTXSID9041815
- PubMed:22649749
- PubMed:19018595
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 198 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 80.00 °C. @ 20.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 193-196 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Color/Form: LIQ Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.878 @ 40 °C/20 °C Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 73.9 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 165 °F OC Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 37.0 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 30.00 to 34.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Physical Description: Liquid; Other Solid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless liquid; [Hawley] May be supercooled liquid; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Physical Description: Colourless crystals; menthol-like camphorous odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: SLIGHTLY SOL IN WATER Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Insoluble in water; soluble in oils Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: Soluble at room temperature (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Vapor Pressure: 0.1 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 0.1 MM HG @ 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (97.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H412 (80.2%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1751 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (96.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 27 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Consumer Uses: Deodorizer Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Intermediate; Deodorizer Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as a menthol and camphor substitute, an antifoaming agent, an odor masking chemical, an esterification agent, and a wax additive; Also used in pharmaceuticals, printing inks, hydraulic fluids, and textile soaps; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Textiles (Fiber & Fabric Manufacturing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: MENTHOL & CAMPHOR SUBSTITUTE; ANTIFOAMING AGENT; HYDRAULIC FLUIDS & TEXTILE SOAPS; PHARMACEUTICALS; WAX ADDITIVE, ESTERIFICATION AGENT, PRINTING INK Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.