Why does CAS 114565-66-1 appear in more than one EU cosmetic annex?

A substance identified by CAS 114565-66-1 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts — for example, restricted under Annex III with specific conditions, while also appearing in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

How do I check if my formula contains a substance with CAS 114565-66-1?

Use the INCI Checker on CosIng Checker with INCI names, CAS numbers or EC numbers. Paste CAS 114565-66-1 to screen it directly, then review every linked annex record and supplier document.

CAS 1 record

CAS 114565-66-1

Q: How do I use CAS 114565-66-1 for compliance screening?

Cross-reference CAS 114565-66-1 against your raw material specification sheets and CoA documents. When it appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met. All annex entries sharing this CAS number are listed on this page.

CAS 114565-66-1 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 114565-66-1

CAS 114565-66-1PubChem CID 53426469

4-(4-(1,3-Dihydroxyprop-2-yl)phenylamino)-1,8-dihydroxy-5-nitroanthraquinone

IUPAC name: 1-[4-(1,3-dihydroxypropan-2-yl)anilino]-4,5-dihydroxy-8-nitroanthracene-9,10-dione

Molecular formula: C23H18N2O8
Molecular weight: 450.4 g/mol
Exact mass: 450.10631554 Da
XLogP3: 3.3
Topological polar surface area: 173.0 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 9
Covalent units: 1
Defined stereocentres: 0

Also known as

EC 406-057-14-[4-(1,3-DIHYDROXYPROP-2-YL)PHENYLAMINO]-1,8-DIHYDROXY-5-NITROANTHRAQUINONERefChem:513543406-057-11-((4-(1,3-Dihydroxypropan-2-yl)phenyl)amino)-4,5-dihydroxy-8-nitroanthracene-9,10-dioneOXIGDVJVFLVGMW-UHFFFAOYSA-N

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID30699229

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match53426469

Attributed physical-property, hazard, environmental and use annotations.

Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P203, P261, P272, P273, P280, P302+P352, P318, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H413: May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Precautionary Statement Codes: P203, P261, P272, P273, P280, P302+P352, P318, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 114565-66-1

1 total

Annex

Entry

1002

4-[4-(1,3-Dihydroxyprop-2-yl)phenylamino]-1,8-dihydroxy-5-nitroanthraquinone

406-057-1

CMR

How CAS 114565-66-1 is used on this site

CAS 114565-66-1 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 114565-66-1 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 114565-66-1 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

The INCI Checker accepts ingredient names, CAS numbers and EC numbers. Check this CAS number directly, then verify the result against supplier specification sheets and every linked annex condition.

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Tools & next steps

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