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CAS 112-53-8

CAS 112-53-8 matches 0 EU annex records across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 112-53-8
CAS 112-53-8PubChem CID 8193

1-Dodecanol

Dodecan-1-ol is a primary alcohol that is dodecane in which a hydrogen from one of the methyl groups is replaced by a hydroxy group. It is registered for use in apple and pear orchards as a Lepidopteran pheromone/sex attractant, used to disrupt the mating behaviour of certain moths whose larvae destroy crops. It has a role as an insect attractant, an insecticide, a pheromone, a cosmetic, a plant metabolite and a bacterial metabolite. It is a primary alcohol and a dodecanol. — ChEBI

IUPAC name
dodecan-1-ol
Molecular formula
C12H26O
Molecular weight
186.33 g/mol
Exact mass
186.198365449 Da
XLogP3
5.1
Topological polar surface area
20.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

Dodecyl alcoholLauryl alcoholn-Dodecyl alcoholLauric alcoholLaurinic alcoholUndecyl carbinolDodecylalcohol1-Hydroxydodecane
16 more reported names
Pisol1-Dodecyl alcoholn-Dodecan-1-olDuodecyl alcoholLorol 5Lorol 7Lauryl 24Alcohol C-12Alfol 12Lorol 11Siponol L5Karukoru 20Lauroyl alcoholDytol J-68Siponol 25Cachalot L-50
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8193

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: SKIN OR EYES: wash exposed areas with water. (USCG, 1999) Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 2.2% (85 of 3888) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H319 (83.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H400 (85.7%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (14%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H411 (24.8%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264+P265, P273, P280, P305+P351+P338, P337+P317, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 3888 reports by companies from 38 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 85 of 3888 reports by companies.; There are 37 notifications provided by 3803 of 3888 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P260, P264, P264+P265, P270, P273, P305+P351+P338, P308+P316, P321, P337+P317, P391, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P260, P264, P264+P265, P270, P305+P351+P338, P308+P316, P337+P317, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: 1-Dodecanol is used principally as chemical intermediate for salts of n-dodecyl sulfate and foam stabilizer for alcohol sulfate surfactants. It is also used in synthetic detergents, lube additives, pharmaceuticals, rubber, textiles, perfumes, and as a flavoring agent. The substance is practically non-toxic, and is a permitted food additive (GRAS) in both the U.S. and the EU. It is registered for pesticide use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. HUMAN EXPOSURE AND TOXICITY: Contact for 48 hours with 4% 1-dodecanol in petrolatum was not irritating to 25 human volunteers, but marked skin irritation was noted when 25% 1-dodecanol in mineral oil was given in open contact with scarified skin of 5 to 10 volunteers once a day for 3 days. There was no skin sensitization in 25 human volunteers at a concentration of 4% in petrolatum. ANIMAL STUDIES: Aspiration of 0.2 mL of 1-dodecanol produced death among 9 out of 10 rats. The deaths were caused by pulmonary edema rather than cardiac arrest or respiratory failure as with the C3 to C10 alcohols. The lun Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 48 was calculated in fish for 1-dodecanol(SRC), using a log Kow of 5.13(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), reported Koc values of 2042-3388 in humic acid(2), indicate that 1-dodecanol is expected to have slight mobility in soil(SRC). Volatilization of 1-dodecanol from moist soil surfaces is expected(SRC) given a Henry's Law constant of 5.19X10-5 atm-cu m/mole(3). However, adsorption to soil is expected to attenuate volatilization(SRC). 1-Dodecanol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 8.48X10-4 mm Hg at 25 °C(4). Theoretical BOD values using standard 5-day aerobic sewage tests ranged from 20-29.7%(5-7) indicate that biodegradation may be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a reported Koc value of 7700 in suspended solids and 2337-11,184 in sediment(2), indicate that 1-dodecanol is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 5.19X10-5 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 27 hours and 12 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The volatilization half-life from a model pond is about 11 months when adsorption is considered(5). 1-Dodecanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(6), an estimated BCF of 48(SRC), from its log Kow of 5.13(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Theoretical BOD values, using standard 5-day aerobic sewage tests ranged from 20-29.7 Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-dodecanol, which has a vapor pressure of 8.48X10-4 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-dodecanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 21 hours(SRC), calculated from its rate constant of 1.8X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). 1-Dodecanol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Emulsifier; Not Known or Reasonably Ascertainable; Cleaning agent; Intermediate; Lubricating agent; Solvent; Solubility enhancer; Surfactant (surface active agent) Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Used to manufacture sulfuric acid esters (wetting agents) and in synthetic detergents, lube additives, pharmaceuticals, rubber, textiles, and perfumes; Also used as a flavoring agent and as a foam stabilizer for alcohol sulfate surfactants; [HSDB] Used to make surfactants for detergents, cleaning products, shampoos, cosmetics, lubricants, wetting agents, emulsifiers, dispersing agents, and antioxidants; Also used to make biocides and disinfectants; 1-Dodecanol is used in foam control, aluminum rolling, metalworking, and in the rubber, textiles, cosmetics, and perfume industries; Also used as a froth flotation agent and a flavoring ingredient in non-alcoholic beverages, ice cream, candy, baked goods, chewing gum, and syrups; [CHEMINFO] Used as Lepidoptera pheromone in apple and pear orchards; [EPA] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Aluminum Producing [Category: Industry]; Metal Machining [Category: Heat or Machine]; Textiles (Fiber & Fabric Manufacturing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Sources/Uses: Used to make detergents, sulfonic acid esters (wetting agents), thiodipropionate, lauryl chloride, specialty ethoxylates, sulfate defoamers, lube additives, pharmaceuticals, rubbers, textiles, perfumes, and foaming agents; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Textiles (Fiber & Fabric Manufacturing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For 1-dodecanol (USEPA/OPP Pesticide Code: 001509 ) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Manufacture of sulfuric acid esters which are used as wetting agents. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Synthetic detergents; lube additives; pharmaceuticals; rubber; textiles; perfumes; flavoring agent. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Principally as chemical intermediate for salts of n-dodecyl sulfate; foam stabilizer for alcohol sulfate surfactants; chemical intermediate for ethoxylated 1-dodecanol, alkyl glyceryl ethers and tri-n-dodecyl trithiophosphate, n-dodecyl derivatives such as lactate, thioglycholate, mercaptopropionate, methacrylate and chloride, n-dodecyl sulfosuccinate salts, n-dodecyloxypropylamine and di-n-dodecyl 3,3'-thiodipropionate, di-n-dodecyl phosphate and di-n-dodecyl hydrogen phosphate Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for 1-DODECANOL (8 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: LAURYL ALCOHOL IS USED IN MFR OF DETERGENTS Source: Hazardous Substances Data Bank (HSDB)
  • Uses: MANUFACTURE OF SULFONIC ACID ESTERS WHICH ARE USED AS WETTING AGENTS Source: Hazardous Substances Data Bank (HSDB)
  • Uses: INTERMEDIATE FOR PRODUCTION OF THIODIPROPIONATE, LAURYL CHLORIDE, SPECIALTY ETHOXYLATES AND SULFATE DEFOAMERS Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
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NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 112-53-8

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How CAS 112-53-8 is used on this site

CAS 112-53-8 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 0 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 112-53-8 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.