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CAS 111-29-5

CAS 111-29-5 matches 0 EU annex records across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 111-29-5
CAS 111-29-5PubChem CID 8105

1,5-Pentanediol

Pentane-1,5-diol is a primary alcohol. — ChEBI

IUPAC name
pentane-1,5-diol
Molecular formula
C5H12O2
Molecular weight
104.15 g/mol
Exact mass
104.083729621 Da
XLogP3
-0.1
Topological polar surface area
40.5 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

1,5-DihydroxypentanePentamethylene glycol1,5-Pentamethylene glycol1,5-Pentylene glycolalpha,omega-Pentanediol07UXZ0SCSTNSC-5927RefChem:73549
16 more reported names
203-854-41,5 PentanediolNSC 59271,5-Pentandiol.alpha.,.omega.-PentanediolEINECS 203-854-4UNII-07UXZ0SCSTBRN 1560130AI3-033181.5-pentanediol9JEpentan-1,5-diol1,5-pentane diol.omega.-PentanediolPentane diol-1,5EC 203-854-4
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8105

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 84.9% (275 of 324) of all reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (15.1%): Harmful if swallowed [Warning Acute toxicity, oral] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 324 reports by companies from 5 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 275 of 324 reports by companies.; There are 3 notifications provided by 49 of 324 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: 1,5-Pentanediol has antimicrobial and antifungal properties in pharmaceutical applications. Additionally, 1,5-pentanediol has reported uses in products for hair loss, cold sores, nail problems, dry and scaly feet, and eczema; it can be used as a moisturizing substance and solvent. In addition, it is used as a plasticizer in cellulose products and adhesives, and in brake fluid compositions. It forms esters and polyesters which can be used as plasticizers, emulsifying agents and resin intermediates. HUMAN STUDIES: 1,5-Pentanediol (5%) was non-irritating to skin in an occlusive patch test. 1,5-Pentanediol (5% and 25% in different tests) was non-sensitizing to skin. A patient was diagnosed with allergic contact dermatitis from resveratrol-containing cream which also contained 1,5-pentanediol. The reaction was attributed to sensitization to 1,5-pentanediol and potential co-sensitization to resveratrol. ANIMAL STUDIES: No-to-mild irritation was observed for undiluted 1,5-pentanediol in rabbit eyes. 1,5-Pentanediol (undiluted) was non-irritating to rabbit skin in both a 24-hour non-occlusive skin test and a 20-hour occlusive patch test on intact and scarified skin. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3.2 was calculated in fish for 1,5-Pentanediol(SRC), using an estimated log Kow of 0.27(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 1,5-pentanediol is expected to have very high mobility in soil(SRC). Volatilization of 1,5-pentanediol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.1X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(3). 1,5-Pentanediol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 3.9X10-3 mm Hg at 25 °C(4). An 83-89% of theoretical BOD using activated sludge in the OECD Manometric Respiromerty test(5) suggests that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 1,5-pentanediol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 3.1X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3.2(SRC), from an estimated log Kow of 0.27(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). An 83-89% of theoretical BOD using activated sludge in the OECD Manometric Respiromerty test(6) suggests that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,5-pentanediol, which has a vapor pressure of 3.9X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,5-pentanediol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 31 hours(SRC), calculated from its rate constant of 1.3X10-11 cu cm/molecule-sec at 25 °C(SRC) (that was derived using a structure estimation method(3). 1,5-Pentanediol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Link: CIR ingredient: 1,5-Pentanediol Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used as plasticizer and brake fluid additive; Also used to make polyesters for emulsifying agents and resin intermediates; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For 1,5-pentanediol (USEPA/OPP Pesticide Code: 690202) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 1,5-Pentanediol is used as a building block in the production of polyesters, thermoplastic polyurethanes, and plasticizers. The linear structure with an uneven number of carbon atoms gives rise to a relatively low viscosity and glass transition temperature (Tg) and good flexibility. 1,5-Pentanediol is also used as an intermediate for dyes and of pharmaceuticals and pesticides. It can be used, for example, for the production of various heterocyclic compounds, such as 1-methylpiperidine. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: As a plasticizer in cellulose products and adhesives, in brake fluid compositions. Forms esters and polyesters which can be used as plasticizers, emulsifying agents and resin intermediates. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: MEDICATION Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 1,5-Pentanediol has been reported to have antimicrobial and antifungal properties in pharmaceutical applications. Additionally, 1,5-Pentanediol has reported uses in products for hair loss, cold sores, nail problems, dry and scaly feet, and eczema; it can be used as a moisturizing substance and solvent. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 111-29-5

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How CAS 111-29-5 is used on this site

CAS 111-29-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 0 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 111-29-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.