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CAS 1 record

CAS 110-00-9

CAS 110-00-9 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 110-00-9
CAS 110-00-9PubChem CID 8029

Furan

Furan is a monocyclic heteroarene with a structure consisting of a 5-membered ring containing four carbons and one oxygen, with formula C4H4O. It is a toxic, flammable, low-boiling (31C) colourless liquid. It has a role as a carcinogenic agent, a hepatotoxic agent and a Maillard reaction product. It is a member of furans, a mancude organic heteromonocyclic parent and a monocyclic heteroarene. — ChEBI

IUPAC name
furan
Molecular formula
C4H4O
Molecular weight
68.07 g/mol
Exact mass
68.026214747 Da
XLogP3
1.3
Topological polar surface area
13.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

Divinylene oxideTetroleFurfuranOxacyclopentadieneOxoleFurane1,4-Epoxy-1,3-butadieneAxole
16 more reported names
NCI-C56202UC0XV6A8N9CHEBI:35559OxycyclopentadieneRefChem:5845203-727-3RCRA waste number U124FurfuraneFuran (98%)Furan (stabilized with BHT)HSDB 89CCRIS 3159EINECS 203-727-3UN2389RCRA waste no. U124UNII-UC0XV6A8N9
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8029

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: Signs and Symptoms of Furan Exposure: Acute exposure to furan may produce dizziness, nausea, vomiting, diarrhea, and anorexia. Irritation and burning of the eyes and skin may occur. Furan vapor is a central nervous system depressant.; Emergency Life-Support Procedures: Acute exposure to furan may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.; Inhalation Exposure:; 1. Move victims to fresh air. Emergency personnel should avoid self-exposure to furan.; 2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.; 3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.; Source: CAMEO Chemicals
  • ERG2024, Guide 128 (Furan): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H224: Extremely flammable liquid and vapor [Danger Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P273, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P317, P318, P319, P321, P330, P332+P317, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H224 (100%): Extremely flammable liquid and vapor [Danger Flammable liquids]; H302+H332 (40.3%): Harmful if swallowed or if inhaled [Warning Acute toxicity, oral; acute toxicity, inhalation]; H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H332 (93.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H341 (99.6%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (99.6%): May cause cancer [Danger Carcinogenicity]; H373 (99.2%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P273, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P317, P318, P319, P321, P330, P332+P317, P362+P364, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 263 reports by companies from 14 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H224: Extremely flammable liquid and vapor [Danger Flammable liquids]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P273, P280, P303+P361+P353, P304+P340, P308+P316, P316, P318, P319, P321, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H224: Extremely flammable liquid and vapor [Danger Flammable liquids]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P303+P361+P353, P304+P340, P308+P316, P316, P318, P319, P321, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 4 - Materials that rapidly or completely vaporize at atmospheric pressure and normal ambient temperature or that are readily dispersed in air and burn readily. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 1 - Materials that in themselves are normally stable but that can become unstable at elevated temperatures and pressures. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Furan is a potent hepatotoxin and hepatocarcinogen in rodents, causing hepatocellular adenomas and carcinomas in rats and mice, and high incidences of cholangiocarcinomas in rats at doses ≥ 2 mg/kg bw. A genotoxic mode of action cannot be excluded for furan-induced tumor formation. Furan is metabolized by cytochrome P450 (CYP) enzymes, predominantly CYP2E1, to its major metabolite cis-2-butene-1,4-dial (BDA, maleic dialdehyde), a highly reactive electrophile identified as the key mediator of furan toxicity and carcinogenicity. Furan-mediated effects on glutathione (GSH) levels and cell viability can be suppressed by the CYP inhibitor 1-phenylimidazole and increased by pretreatment of rats with acetone (a CYP2E1-inducing agent), indicating that furan cytotoxicity depends on its metabolic activation. BDA has been shown to react with cellular nucleophiles such as GSH and amino acids and to cause cross-links between thiols and amino groups, giving rise to lactam and pyrrole derivatives. Furan reduced the percentage of DNA in the comet tail in turkey liver fetal hepatocytes. Furan was also shown to induce chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster o Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: BCFs of 0.9-1.5 and <3.2-13 were measured in carp (Cyprinus carpio) at furan concentrations of 1 and 0.1 mg/L, respectively(1). According to a classification scheme(2), these BCFs suggest the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 80(SRC), determined from a structure estimation method(2), indicates that furan is expected to have high mobility in soil(SRC). Volatilization of furan from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 5.4X10-3 atm-cu m/mole(SRC), based upon its vapor pressure, 600 mm Hg(3), and water solubility, 10,000 mg/L(4). Furan is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). A 4% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 80(SRC), determined from a structure estimation method(2), indicates that furan is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 5.4X10-3 atm-cu m/mole(SRC), derived from its vapor pressure, 600 mm Hg(4), and water solubility, 10,000 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.5 hours and 3.3 days, respectively(SRC). According to a classification scheme(6), BCFs of 0.9-1.5 and <3.2-13 measured in carp (Cyprinus carpio) at furan concentrations of 1 and 0.1 mg/L(7), respectively, suggest that bioconcentration in aquatic organisms is low(SRC). A 4% of theoretical BOD using activated sludge in the Japanese MITI test(7) suggests that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), furan, which has a vapor pressure of 600 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase furan is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 9 to 10 hours, calculated from its rate constants of 3.83X10-11 to 4.23X10-11 cu cm/molecule-sec(3-5). Furan will also react with nitrate radicals and ozone radicals in the atmosphere with half-lives of 50 minutes and 4.5 to 4.6 days, calculated from rate constants of 1.4X10-12 cu cm/molecule sec(4) and 2.4X10-18(4) to 2.5X10-18(6), respectively. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
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NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 110-00-9

1 total

How CAS 110-00-9 is used on this site

CAS 110-00-9 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 110-00-9 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

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A substance identified by CAS 110-00-9 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

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