CAS 107-98-2PubChem CID 7900
1-Methoxy-2-propanol
1-methoxy-2-propanol appears as a colorless liquid. Flash point near 89 °F. Less dense than water. Contact irritates skin, eyes and mucous membranes. Prolonged exposure to vapors may cause coughing, shortness of breath, dizziness and intoxication. Vapors heavier than air. Used as a solvent and as an antifreeze agent. — CAMEO Chemicals
- IUPAC name
- 1-methoxypropan-2-ol
- Molecular formula
- C4H10O2
- Molecular weight
- 90.12 g/mol
- Exact mass
- 90.068079557 Da
- XLogP3
- -0.2
- Topological polar surface area
- 29.5 Ų
- Hydrogen-bond donors
- 1
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
MethoxyisopropanolClosol1-Methoxy-2-hydroxypropanePGME2-Propanol, 1-methoxy-Dowtherm 209Propylene glycol monomethyl etherPropasol solvent M
16 more reported names
Dowanol 33BMethyl proxitol2-Methoxy-1-methylethanolDowanol-33BPropylene glycol 1-methyl etherUcar Solvent LM (Obs.)Glycol ether pmNSC-240974Z7JO8V3UPropylenglykol-monomethylaetherRefChem:76154Methoxy ether of propylene glycolalpha-Propylene glycol monomethyl ether203-539-1Dowanol PMKuraray PGM
External database identifiers
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match7900
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 270 °C at 1013 hPa Source: Hazardous Substances Data Bank (HSDB)
- Autoignition Temperature: 270 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 248 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 120 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 120 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 248 °F Source: Occupational Safety and Health Administration (OSHA)
- Boiling Point: 119 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Boiling Point: 248 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Color/Form: Colorless liquid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Clear, colorless liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.924 at 68 °F (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
- Density: 0.9620 at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 0.92 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 0.96 Source: Occupational Safety and Health Administration (OSHA)
- Density: 0.9620 @ 20°C Source: PAC Chemical Database, U.S. Department of Energy
- Density: 0.96 Source: The National Institute for Occupational Safety and Health (NIOSH)
- Flash Point: 97 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 32 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 90 °F (32 °C) (closed cup) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 97 °F (Open cup) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 38 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Flash Point: 97 °F Source: Occupational Safety and Health Administration (OSHA)
- Flash Point: 97 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Melting Point: -139 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: -95 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -96 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -139 °F (sets to glass) Source: Occupational Safety and Health Administration (OSHA)
- Melting Point: -95 °C Source: PAC Chemical Database, U.S. Department of Energy
- Melting Point: -139 °F (Sets to glass) Source: The National Institute for Occupational Safety and Health (NIOSH)
- Odor: Weak pleasant odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: Mild, ethereal odor Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: 1-methoxy-2-propanol appears as a colorless liquid. Flash point near 89 °F. Less dense than water. Contact irritates skin, eyes and mucous membranes. Prolonged exposure to vapors may cause coughing, shortness of breath, dizziness and intoxication. Vapors heavier than air. Used as a solvent and as an antifreeze agent. Source: CAMEO Chemicals
- Physical Description: Liquid; Wet Solid; CBI Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Clear, colorless liquid with a mild, ethereal odor; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: Clear, colorless liquid with a mild, ethereal odor. Source: Occupational Safety and Health Administration (OSHA)
- Physical Description: Clear, colorless liquid with a mild, ethereal odor. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Refractive Index: Index of refraction = 1.4034 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Solubility: greater than or equal to 100 mg/mL at 66 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: In water, 100 mg/mL at 19 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible with water Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible in all proportions with organic solvents Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Solubility in water: very good Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: Miscible Source: The National Institute for Occupational Safety and Health (NIOSH)
- Vapor Pressure: 11.8 mmHg at 77 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 12.5 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 12.5 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 20 °C: 1.2 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 12 mmHg Source: Occupational Safety and Health Administration (OSHA)
- Vapor Pressure: 12.5 [mm Hg] @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Vapor Pressure: (77 °F): 12 mmHg Source: The National Institute for Occupational Safety and Health (NIOSH)
- Viscosity: 1.81 mPa-s at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its aerosol or vapour, through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: inhalation, ingestion, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
- ERG2024, Guide 129 (1-Methoxy-2-propanol): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water wash - If this chemical contacts the skin, wash the contaminated skin with water.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Note: This chemical does not meet GHS hazard criteria for < 0.1% (2 of 9011) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids]; H336 (99%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P319, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 9011 reports by companies from 67 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 9011 reports by companies.; There are 66 notifications provided by 9009 of 9011 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
- NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Target Organs: Nervous Source: EPA Integrated Risk Information System (IRIS)
- Target Organs: Eyes, skin, respiratory system, central nervous system Source: The National Institute for Occupational Safety and Health (NIOSH)
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Toxicity Summary: IDENTIFICATION AND USE: In the literature 1-methoxy-2-propanol is often referred to as propylene glycol monomethyl ether (PGME). Commercial PGME (CAS 130-67-8) typically contains at least 98.5% 1-methoxy-2-propanol (alpha isomer) and only 1.5% of 2-methoxy-1-propanol (beta isomer). PGME is a colorless liquid, miscible with water and many organic solvents. This makes it useful for a wide variety of solvent applications in the manufacture of lacquers, paints, dyes, inks, cleaning agents and liquid soaps. HUMAN EXPOSURE AND TOXICITY: PGME alpha (1-methoxy-2-propanol) has low toxicity. In male volunteers, following exposure to 100 ppm of PGME the subjects felt that the odor was too strong to be tolerated, but odor tolerance developed within 25 min. During a 3.5-hr exposure at 100 ppm, mild eye irritation was noted in 3 of the 6 individuals. At 250 ppm, the majority of the 23 subjects exposed for 1-7 hr complained of eye, nose or throat irritation; several subjects developed headaches, and one was nauseated. None of the exposures resulted in changes in visual, coordination, neurological or brake-reaction tests. Clinical studies (e.g., blood cell count, SGOT, SGPT, BUN and complete urina Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for 1-methoxy-2-hydroxypropane(SRC), using an estimated log Kow of -0.49(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 1-methoxy-2-hydroxypropane is expected to have very high mobility in soil(SRC). Volatilization of 1-methoxy-2-hydroxypropane from moist soil surfaces is not expected to be an important fate process(SRC) given a Henry's Law constant of 9.2X10-7 atm-cu m/mole(3). 1-Methoxy-2-hydroxypropane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 12.5 mm Hg at 25 °C(4). Aerobic degradation using a sandy loam soil resulted in half-lives of <1 and <7 days at 0.2 and 100 ppm, respectively(5), indicating that biodegradation may be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 1-methoxy-2-hydroxypropane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 9.2X10-7 atm-cu m/mole(4). 1-Methoxy-2-hydroxypropane is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of -0.49(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 90% of theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation is an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-methoxy-2-hydroxypropane, which has a vapor pressure of 12.5 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-methoxy-2-hydroxypropane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 21 hours(SRC), calculated from its rate constant of 1.86X10-11 cu cm/molecule-sec at 25 °C(3). 1-Methoxy-2-hydroxypropane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Cleaning agent; Not Known or Reasonably Ascertainable; Corrosion inhibitor; Pigment; Solvent; Dispersing agent; Other; Lubricating agent Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: UV stabilizer; Solubility enhancer; Processing aids not otherwise specified; Dispersing agent; Solvent; Other; Pigment; Drier; Adhesion/cohesion promoter; Intermediate; Sealant (barrier); Waterproofing agent; Thickening agent; Corrosion inhibitor; Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Cosmetic Ingredient Review Link: CIR ingredient: Methoxyisopropanol Source: Cosmetic Ingredient Review (CIR)
- Sources/Uses: Used as a solvent in paints, inks, nail polish removers, and cleaning agents; Also used in finishing leather and in electronics and agriculture; [ACGIH] Used to make lacquers and paints, as a solvent for resins, celluloses, acrylics, dyes, and inks (gravure, flexographic and silk screening), as antifreeze, and in household cleaners and spot removers; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Painting (Solvents) [Category: Paint]; Plastic Composites Manufacturing [Category: Industry]; Leather Tanning and Processing [Category: Industry]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry]; Silk-Screen Printing [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Chiefly used in manufacture of lacquers and paints. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Solvent for celluloses, acrylics, dyes, inks, stains; solvent-sealing of cellophane. Source: Hazardous Substances Data Bank (HSDB)
- Uses: 1-Methoxy-2-propanol ... has been used as an antifreeze material, principally in ebullient cooling systems and in some heavy-duty diesel engines. Source: Hazardous Substances Data Bank (HSDB)
- Uses: ... As a solvent component in paints and printing inks, improves the wetting of some pigments and colorants. It has a good solvency for cellulose nitrate, cellulose ethers, chlorinated rubber, poly(vinyl acetate), poly(vinyl butyral), ketone and ketone-formaldehyde resins, shellac, colophony, phenol-, melamine-, and urea-formaldehyde resins, alkyd resins, polyacrylates, polymethacrylates, castor oil, linseed oil, and some vinyl chloride copolymers. ... Being a moderately volatile solvent, it improves paint penetration, flow properties, and the gloss of paint coats; it also prevents blushing and formation of fish eyes and blisters. Addition of methoxypropanol does not delay the drying of paint systems. Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for 1-METHOXY-2-HYDROXYPROPANE (10 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | No exact record | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.