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CAS 1 record

CAS 106-94-5

CAS 106-94-5 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 106-94-5
CAS 106-94-5PubChem CID 7840

1-Bromopropane

1-bromopropane is a bromoalkane that is propane carrying a bromo substituent at position 1. It has a role as a solvent and a neurotoxin. It is a bromohydrocarbon and a bromoalkane. — ChEBI

IUPAC name
1-bromopropane
Molecular formula
C3H7Br
Molecular weight
122.99 g/mol
Exact mass
121.97311 Da
XLogP3
2.1
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

N-Propyl bromidePropyl bromidePropane, 1-bromo-1-BROMO-PROPANEpropylbromiden-propylbromideCCRIS 30Y9746DNE68
16 more reported names
CHEBI:471051-BP, propaneRefChem:430780203-445-0Propane, bromo-BROMOPROPANE1-Propyl bromide1-Bromopropane-d7Bromopropane, 1-HSDB 1068EINECS 203-445-0bromo-propaneUNII-Y9746DNE681-propylbromide1-BP3-bromopropane
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:47105

1-bromopropane

A bromoalkane that is propane carrying a bromo substituent at position 1.

Formula
C3H7Br
Average mass
122.993 g/mol
Monoisotopic mass
121.97311 Da
Formal charge
0
  • bromoalkane — is a (CHEBI:22929)
  • bromohydrocarbon — is a (CHEBI:22926)
  • neurotoxin — has role (CHEBI:50910)
  • solvent — has role (CHEBI:46787)
  • neurotoxin — has role (CHEBI:50910)
  • solvent — has role (CHEBI:46787)
  • bromoalkane — is a (CHEBI:22929)
  • bromohydrocarbon — is a (CHEBI:22926)
Additional curated names
1-bromopropanen-propyl bromide
Cross-references from this source
  • CAS: 106-94-5 — ChemIDplus
  • MANUAL_X_REF: 3BR — PDBeChem
  • MANUAL_X_REF: N-Propyl_bromide — Wikipedia
  • REGISTRY_NUMBER: 505936 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2021-05-20. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7840

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: Call a physician.; EYES: Flush with running water for at least 15 minutes.; SKIN: Remove contaminated clothing and shoes, flush affected areas with water for at least 15 minutes.; INHALATION: Move to fresh air. If breathing has stopped, give artificial respiration. If breathing is difficult, give oxygen.; INGESTION: Do nothing except keep victim warm. (USCG, 1999) Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360FD: May damage fertility; May damage the unborn child [Danger Reproductive toxicity]; H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (85.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336 (99.4%): May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H360 (95.8%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H373 (99.9%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 720 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P273, P280, P303+P361+P353, P304+P340, P305+P351+P338, P317, P318, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P317, P318, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: Skin irritation if contacts skin, redness and itching of skin and eyes. Acute exposure may lead to coughing, shortness of breath, headache, nausea, vomiting. Chronic exposure can lead to damage of the blood, liver and CNS. Neurotoxicity can arise due to chronic exposure through inhalation or skin. Human cases of 1-bromopropane (1-BP) toxicity exhibit ataxic gait and cognitive dysfunction, whereas rat studies showed pyknotic shrinkage in cerebellar Purkinje cells and electrophysiological changes in the hippocampus. Inhalation exposure to 1-bromopropane causes skin tumors in male rats, large intestine tumors in female and male rats, and lung tumors in female mice. 1-bromopropane, either directly or via reactive metabolites, can cause molecular alterations that typically are associated with carcinogenesis, including genotoxicity, oxidative stress, and glutathione depletion. Hepatotoxicity and reproductive toxicity have been noted in rodent studies. Source: Toxin and Toxin Target Database (T3DB)
  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: 1-Bromopropane (1-BP) is a colorless liquid. 1-BP is used primarily as a solvent cleaner in vapor and immersion degreasing operations to clean optics, electronics, and metals and as a solvent vehicle in industries using aerosol-applied adhesives, such as foam cushion manufacturing. HUMAN STUDIES: Occupational exposure to 1-BP has been linked to neurological illnesses. Exposure to 1-BP could adversely affect peripheral nerves or/and the central nervous system. A 43-year-old male industrial worker developed muscle weakness, pain, numbness, and gait disturbance. Neurological examination indicated sensory ataxic neuropathy associated with mild impairment of upper motor neurons. He had used 1-BP as a cleaning agent for metal parts at his workplace without appropriate protection. Another case study reported that a 19-year-old male experienced weakness of the lower extremities and the right hand, numbness, and difficulty swallowing and urinating after 2 months of occupational exposure to a degreasing solvent based on 1-BP. 1-BP is cytotoxic but not corrosive, based on results from a cultured reconstructed human epidermal model (EpiDerm Skin Corrosivity Test). 1-BP Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: Organobromide compounds, especially alkylbromides are strong alkylating agents. Consequently they can randomly modify the surfaces of proteins and lipids, leading to the disruption of enzyme, transporter or membrane functions. Alkylation of DNA by alkylbromides may also lead to mutations. 1-bromopropane reacts quickly with hepatic glutathione (GSH) leading to its rapid depletion and subsequent liver damage. Long-term exposure to 1-bromopropane decreases neurogenesis in the dentate gyrus which may contribute to the neurotoxicity. Downregulation of brain derived neurotrophic factor and glucocoritoid receptor mRNA expression and low hippocampal norepinephrine levels might contribute, at least in part, to the reduced neurogenesis. Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 11 was calculated in fish for 1-bromopropane(SRC), using a measured log Kow of 2.10(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). 1-Bromopropane was classified as having low bioconcentration based on fish accumulation studies (specific data not reported)(4). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 37(SRC), determined from a structure estimation method(2), indicates that 1-bromopropane is expected to have very high mobility in soil(SRC). Volatilization of 1-bromopropane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 7.3X10-3 atm-cu m/mole(SRC) derived from a vapor pressure of 111 mm Hg(3) and water solubility of 2450 mg/L(4). 1-Bromopropane is expected to volatilize from dry soil surfaces based upon its vapor pressure(SRC). A 70% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation may be an important environmental fate process in soil(SRC). A number of pure culture studies(6-9) have shown that microorganisms are capable of degrading 1-bromopropane. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 37(SRC), determined from a structure estimation method(2), indicates that 1-bromopropane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 7.3X10-3 atm-cu m/mole(SRC), derived from a vapor pressure of 111 mm Hg(4) and water solubility of 2450 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 3.4 hours and 4.4 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 11(SRC), from its log Kow of 2.10(7) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The hydrolysis half-life of 1-bromopropane is approximately 26 days at pH 7 and 25 °C(8). A 70% of theoretical BOD using activated sludge in the Japanese MITI test(9) suggests that biodegradation may be an important environmental fate process in water(SRC). A number of pure culture studies(10-13) have shown that microorganisms are capable of degrading 1-bromopropane. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1-bromopropane, which has a vapor pressure of 111 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1-bromopropane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 15 days(SRC), calculated from its rate constant of 1.06X10-12 cu cm/molecule-sec at 25 °C(3). 1-Bromopropane does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used as a solvent substitute to clean metals and electronics, in adhesive and coating applications, and in aerosol propellant applications. Has also been used to replace perchloroethylene in dry cleaning; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Metal Degreasing [Category: Clean]; Painting (Solvents) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Dry Cleaning [Category: Clean] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Solvent for fats, waxes and resins; intermediate in synthesis of pharmaceuticals, insecticides and other compounds; in spray adhesives; degreaser; cleaner for metal and precision electronic components. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Production of penconazole, valproic acid /From table/ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: In the early to mid 1990s, 1-bromopropane was used primarily as an intermediate in the production of pesticides, quaternary ammonium compounds, flavors and fragrances, pharmaceuticals, and other chemicals in well-controlled, closed processes. In the mid to late 1990s, it was introduced as a less toxic replacement for methylene chloride in emissive applications such as vapor and immersion degreasing operations and critical cleaning of electronics and metals. 1-Bromopropane was also introduced as a nonflammable, nontoxic, fast-drying, and inexpensive solvent for adhesive resins, and has been marketed as a replacement for ozone depleting refrigerants. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 1-Bromopropane is used primarily as a solvent cleaner in vapor and immersion degreasing operations to clean optics, electronics, and metals and as a solvent vehicle in industries using aerosol-applied adhesives, such as foam cushion manufacturing. ...1-Bromopropane also has potential for use as a spot remover in the textile industry... In the past, 1-bromopropane was used primarily as a solvent for fats, waxes, and resins and as an intermediate in the synthesis of pharmaceuticals, insecticides, quaternary ammonium compounds, flavors, and fragrances in generally well-controlled, closed processes. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Cleaning solvent, drycleaning solvent, aerosol glue solvent. 1-bromopropane may be found in products used in vapor and immersion degreasing operations for cleaning metal, plastics, electronic and optical components; in adhesive spray applications; and in dry cleaning operations. 1-bromopropane may also be a component of some aerosol spray products. Exposures to 1-bromopropane in occupational settings occur via two primary routes: (1) inhalation of 1-bromopropane vapors and mists; and (2) skin contact with 1-bromopropane. Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 106-94-5

1 total

How CAS 106-94-5 is used on this site

CAS 106-94-5 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 106-94-5 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

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A substance identified by CAS 106-94-5 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

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A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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