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CAS 1 record

CAS 106-46-7

CAS 106-46-7 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 106-46-7
CAS 106-46-7PubChem CID 4685

1,4-Dichlorobenzene

P-dichlorobenzene appears as a white colored liquid with the odor of moth balls. Denser than water and insoluble in water. Flash point below 200 °F. Used as a moth repellent, to make other chemicals, as a fumigant, and for many other uses. — CAMEO Chemicals

IUPAC name
1,4-dichlorobenzene
Molecular formula
C6H4Cl2
Molecular weight
147.00 g/mol
Exact mass
145.9690055 Da
XLogP3
3.4
Topological polar surface area
0.0 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
0
Covalent units
1
Defined stereocentres
0

Also known as

p-DichlorobenzeneparadichlorobenzeneParacideParamothParadowParanuggetsSantochlorEvola
16 more reported names
Persia-perazolp-Dichlorobenzolp-Chlorophenyl chlorideBenzene, 1,4-dichloro-GlobolParadip-DichlorbenzolDi-chloricidePara crystalsParadichlorbenzolpara-DichlorobenzeneDichlorocidePDCBp-Diclorobenzenep-DichloorbenzeenParadichlorobenzol
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:28618

1,4-dichlorobenzene

A dichlorobenzene carrying chloro groups at positions 1 and 4.

Formula
C6H4Cl2
Average mass
147.004 g/mol
Monoisotopic mass
145.96901 Da
Formal charge
0
  • dichlorobenzene — is a (CHEBI:23697)
  • insecticide — has role (CHEBI:24852)
  • insecticide — has role (CHEBI:24852)
  • dichlorobenzene — is a (CHEBI:23697)
Additional curated names
1,4-dichlorobenzene1,4-Dichlorobenzenep-chlorophenyl chloridep-DichlorbenzolPARAParadichlorbenzolparadichlorobenzenePDCBp-Dichlorobenzene
Cross-references from this source
  • CAS: 106-46-7 — ChemIDplus
  • CAS: 106-46-7 — NIST Chemistry WebBook
  • CAS: 106-46-7 — KEGG COMPOUND
  • MANUAL_X_REF: 1,4-Dichlorobenzene — Wikipedia
  • MANUAL_X_REF: c0593 — UM-BBD
  • MANUAL_X_REF: C07092 — KEGG COMPOUND
  • MANUAL_X_REF: HMDB0041971 — HMDB
  • MANUAL_X_REF: WO2010122925 — Patent
  • REGISTRY_NUMBER: 1680023 — Reaxys
  • REGISTRY_NUMBER: 49722 — Gmelin

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2015-10-23. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match4685

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Ap Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash - If this chemical contacts the skin, wash the contaminated skin with soap and water.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P264+P265, P273, P280, P305+P351+P338, P318, P337+P317, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]; H400 (91%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P264+P265, P273, P280, P305+P351+P338, P318, P337+P317, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 402 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P308+P316, P318, P319, P321, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P264, P264+P265, P270, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P308+P316, P318, P319, P321, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Health Effects: Prolonged exposure to high concentration of 1,4-DCB may cause weakness, dizziness, loss of weight, liver injury. Chronic (months to years) ingestion of 1,4-DCB products can provoque skin blotches and problems with red blood cells, such as anemia. There is an indication that 1,4-DCB can affect the development of the nervous system after birth. 1,4-DCB is possibly a human carcinogen. (L395, T63) Source: Toxin and Toxin Target Database (T3DB)
  • NFPA Health Rating: 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: 1,4-Dichlorobenzene (p-DCB) is a solid. It is used as moth repellent, general insecticide, germicide, space odorant, in manufacture of 2,5-dichloroaniline, dyes, intermediates, pharmacy, agriculture (fumigating soil). HUMAN STUDIES: Fumes from the surface of hot p-DCB may irritate skin slightly when contact is repeated or prolonged. Leukoencephalopathy has been described following ingestion of p-DCB mothballs. Hemolytic anemia and methemoglobinemia is more rarely reported in such cases. p-DCB increased the frequency of sister chromatid exchange in human peripheral blood lymphocytes in the absence of metabolic activation. ANIMAL STUDIES: p-DCB induces renal tumors specifically in male rats through an alpha2u-globulin-associated response. p-DCB failed to exhibit genotoxic effects in vivo, exhibiting negative responses in unscheduled DNA synthesis, in the chromosome aberration assay, in the dominant lethal assay, and in the in vivo micronucleus assay. It was reported as positive in one DNA strand breakage assay and in one in vivo micronucleus assay. p-DCB bound to DNA in the liver, lung, and kidney of mice but not in that of male rats. It also induced DNA damag Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: The hepatotoxicity and nephrotoxicity observed in laboratory animals are likely due to the formation of toxic intermediates formed while converting 1,4-DCB to 2,5-dichlorophenol by cytochrome P-450, or by depletion of GSH at higher doses of 1,4-DCB, or both. (L395) Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: A mean BCF value of 78 was measured in mosquito fish exposed to 57-233 ug/L of 1,4-dichlorobenzene during 1 to 4 day incubation periods(1). Mean BCF values of 370 to 720 were experimentally determined for rainbow trout exposed to unspecified concentrations of 1,4-dichlorobenzene up to 119 days in laboratory aquariums(2). A whole body BCF of 60 was determined for bluegill sunfish exposed to 1,4-dichlorobenzene over a 28-day period in a continuous flow system(3). BCF values of 33 to 73 were measured in carp exposed to 2 ug/L of 1,4-dichlorobenzene during an 35 day incubation period and BCF values of 47 to 190 were measured in carp exposed to 0.2 ug/L of 1,4-dichlorobenzene during a 35 day incubation period(4). According to a classification scheme(5), these BCF values suggest that bioconcentration in aquatic organisms is moderate to high(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 273(2) and 390(3) indicate that 1,4-dichlorobenzene is expected to have moderate mobility in soil(SRC). Volatilization of 1,4-dichlorobenzene from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 2.41X10-3 atm-cu m/mole(4). 1,4-Dichlorobenzene is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.74 mm Hg at 25 °C(5). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(6) indicating that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values of 273(2) and 290(3) indicate that 1,4-dichlorobenzene is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon a Henry's Law constant of 2.41X10-3 atm-cu m/mole(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 4 hours and 5 days, respectively(SRC). According to a classification scheme(6), BCF values ranging from 33-720(7-10) suggest the potential for bioconcentration in aquatic organisms is moderate to high(SRC). Utilizing the Japanese MITI test, 0% of the Theoretical BOD was reached in 4 weeks(10) indicating that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,4-dichlorobenzene, which has a vapor pressure of 1.7 mm Hg at 25 °C(2), is expected to exist solely in the vapor phase in the ambient atmosphere. Vapor-phase 1,4-dichlorobenzene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 40 days(SRC), calculated from its rate constant of 3.2X10-13 cu cm/molecule-sec at 25 deg(3). 1,4-Dichlorobenzene does not contain chromophores that absorb at wavelengths >290 nm and, therefore, is not expected to undergo direct photolysis by sunlight(4). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 1,4-Dichlorobenzene is used mainly as a fumigant for the control of moths, molds, and mildews, and as a space deodorant for toilets and refuse containers. Source: EPA Hazardous Air Pollutants
  • Sources/Uses: Used as an insecticide and fumigant; [ACGIH] Used as a deodorizer for toilets and garbage cans; Also used as a moth repellent and chemical intermediate; [CHEMINFO] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Farming (Pesticides) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For 1,4-dichlorobenzene (USEPA/OPP Pesticide Code: 061501) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Insecticidal fumigant. For domestic use against clothes moths; as space deodorant in room deodorizers, toilet bowl blocks and diaper pail deodorizers. Intermediate in production of plastics for electronic components. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Para-Dichlorobenzene is limited to indoor use only. It is used as a moth and beetle repellant in products which are applied to commercial and residential use sites such as closets and storage containers, and to repel lice and mites from bird cages. It is also used in empty bee supers (stored indoors), to repel wax moths. When formulated into varpal rope, it is used in attics to repel snakes, mice, rats, squirrels, and bats. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Moth repellent, general insecticide, germicide, space odorant, manufacture of 2,5-dichloroaniline, dyes, intermediates, pharmacy, agriculture (fumigating soil). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for 1,4-Dichlorobenzene (6 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: 1,4-DCB is used a pesticide and a deodorant, most famously in mothballs in which it is a replacement for the more traditional naphthalene. 1,4-DCB is also used as a precursor in the production of the polymer poly(p-phenylene sulfide). 1,4-DCB also is used to make deodorant blocks used in garbage cans and restrooms, and to help control odors in animal-holding facilities. 1,4-DCB has been used as an insecticide on fruit and as an agent to control mold and mildew growth on tobacco seeds, leather, and some fabrics. Recently, using 1,4-DCB to make resins has become very important. Exposure may result from breathing vapors from 1,4-DCB products, drinking contaminated water or eating contaminated food (However, the levels of p-DCB in foods are generally low), and eye exposure. (L393, L395, L397) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 106-46-7

1 total

How CAS 106-46-7 is used on this site

CAS 106-46-7 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 106-46-7 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

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A substance identified by CAS 106-46-7 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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