
Ethyl Propionate
Ethyl propionate is a propanoate ester of ethanol. It has a role as a metabolite. — ChEBI
- IUPAC name
- ethyl propanoate
- Molecular formula
- C5H10O2
- Molecular weight
- 102.13 g/mol
- Exact mass
- 102.068079557 Da
- XLogP3
- 1.2
- Topological polar surface area
- 26.3 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:41330
- ChEMBL:CHEMBL44115
- EPA DTXSID:DTXSID1040110
- PubMed:22524192
- PubMed:22489153
- PubMed:22369235
- PubMed:22120647
- PubMed:22093681
- PubMed:21799756
- PubMed:21566191
- PubMed:21436880
- PubMed:21409253
- PubMed:21338776
- PubMed:21042539
- PubMed:20954169
Evidence from additional scientific databases
EMBL-EBI ChEBI
ethyl propionate
A propanoate ester of ethanol.
- Formula
- C5H10O2
- Average mass
- 102.133 g/mol
- Monoisotopic mass
- 102.06808 Da
- Formal charge
- 0
- propanoate ester — is a (CHEBI:36243)
- metabolite — has role (CHEBI:25212)
- metabolite — has role (CHEBI:25212)
- propanoate ester — is a (CHEBI:36243)
Additional curated names
Cross-references from this source
- CAS: 105-37-3 — ChemIDplus
- CAS: 105-37-3 — NIST Chemistry WebBook
- REGISTRY_NUMBER: 506287 — Reaxys
- MANUAL_X_REF: CA1 — PDBeChem
- MANUAL_X_REF: HMDB0030058 — HMDB
Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2020-07-07. Retrieved: 2026-08-31. Open source record
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 887 °F (USCG, 1999) Source: CAMEO Chemicals
- Autoignition Temperature: 824 °F (440 °C) Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 210 °F at 760 mmHg (USCG, 1999) Source: CAMEO Chemicals
- Boiling Point: 99.2 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 98.00 to 100.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 99 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Boiling Point: 99 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Color/Form: Colorless liquid Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Water-white liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.891 (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
- Density: 0.8917 @ 20 °C/4 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.886-0.889 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Density: 0.891 @ 20°C Source: PAC Chemical Database, U.S. Department of Energy
- Flash Point: 54 °F (USCG, 1999) Source: CAMEO Chemicals
- Flash Point: 12 °C (CLOSED CUP) Source: Hazardous Substances Data Bank (HSDB)
- LogP: log Kow= 1.21 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 1.21 Source: Human Metabolome Database (HMDB)
- Melting Point: -99 °F (USCG, 1999) Source: CAMEO Chemicals
- Melting Point: -73.9 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -73 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -72.6 °C Source: PAC Chemical Database, U.S. Department of Energy
- Odor: REMINISCENT OF RUM & PINEAPPLE Source: Hazardous Substances Data Bank (HSDB)
- Odor: Fruity odor Source: Hazardous Substances Data Bank (HSDB)
- Odor: Odor of pineapple Source: Hazardous Substances Data Bank (HSDB)
- Odor: Butter- or rum-like Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Ethyl propionate appears as a clear colorless liquid with a pineapple-like odor. Flash point 54 °F. Less dense than water and insoluble in water. Vapors are heavier than air. Source: CAMEO Chemicals
- Physical Description: Colorless liquid with a fruity odor; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: Colourless liquid with a fruity, rum-like, ethereal odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Refractive Index: Index of refraction: 1.3844 @ 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.383-1.385 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: SOLUBLE IN MOST ORGANIC SOLVENTS Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in alcohol and ether Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible in ethanol and ethyl ether; soluble in acetone Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 19,200 mg/l @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 19.2 mg/mL at 20 °C Source: Human Metabolome Database (HMDB)
- Solubility: Soluble in most fixed oils and propylene glycol, soluble in water (1ml in 42ml) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Vapor Pressure: 35.9 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: Vapor pressure: 40 mm Hg @ 27.2 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 35.8 mm Hg @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 40 [mm Hg] @27.2 °C Source: PAC Chemical Database, U.S. Department of Energy
- First Aid: Get medical attention.; INHALATION: Remove to fresh air. If breathing has stopped, give artificial respiration. If breathing is difficult, give oxygen.; EYES: Flush with water for at least 15 min., lifting lids occasionally. Contact lenses should not be worn when working with this chemical.; SKIN: Remove contaminated clothing and shoes. Wash with soap and water. (USCG, 1999) Source: CAMEO Chemicals
- ERG2024, Guide 129 (Ethyl propionate): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H225 (> 99.9%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H315 (10.6%): Causes skin irritation [Warning Skin corrosion/irritation]; H335 (10.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P319, P321, P332+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1889 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids] Source: NITE-CMC
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- NFPA Health Rating: 0 - Materials that, under emergency conditions, would offer no hazard beyond that of ordinary combustible materials. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: An estimated BCF of 1.7 was calculated for ethyl propionate(SRC), using a log Kow of 1.21(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low. Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a structure estimation method(2), indicates that ethyl propionate is expected to have very high mobility in soil(SRC). Volatilization of ethyl propionate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.5X10-4 atm-cu m/mole(SRC), from its vapor pressure, 35.8 mm Hg(4), and water solubility, 1.92X10+4 mg/l(3). The potential for volatilization of ethyl propionate from dry soil surfaces may exist(SRC) based upon a vapor pressure of 35.8 mm Hg(4). Biodegradation in soil is expected to be an important environmental fate process because of the presence of an easily biodegraded ester functional group(5). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a structure estimation method(2), indicates that ethyl propionate is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 2.5X10-4 atm-cu m/mole(SRC), from its vapor pressure, 35.8 mm Hg(4), and water solubility, 19,200 mg/l(7). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 6 hrs and 5 days, respectively(SRC). According to a classification scheme(5), an estimated BCF of 1.7(SRC), from its log Kow of 1.21(6) and a regression-derived equation(9), suggests the potential for bioconcentration in aquatic organisms is low. Biodegradation in water is expected to be an important environmental fate process because of the presence of an easily biodegraded ester functional group(8). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethyl propionate, which has a vapor pressure of 3.58X10+1 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase ethyl propionate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 7 days(SRC), calculated from its rate constant of 2.14X10-12 cu cm/molecule-sec at 25 °C(3). Source: Hazardous Substances Data Bank (HSDB)
- Sources/Uses: Used as solvent (cellulose ethers/esters, lacquers, and resins), flavoring and fragrance agent, and cutting agent (pyroxylin); [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Painting (Solvents) [Category: Paint] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Solvent for cellulose ethers and esters, various natural and synthetic resins; flavoring agent, fruit syrups, cutting agent for pyroxylin. Source: Hazardous Substances Data Bank (HSDB)
- Uses: FRAGRANCE, EG, FOR CHEWING GUM, BAKED GOODS & CANDY; SOLVENT, EG, FOR CELLULOSE ETHERS & ESTERS; CHEM INT FOR PYRIMETHAMINE (ANTIMALARIAL) Source: Hazardous Substances Data Bank (HSDB)
- Uses: Ethyl propionate is used in ... the lacquer industry ... Source: Hazardous Substances Data Bank (HSDB)
- Uses: Flavoring, fragrance Source: Hazardous Substances Data Bank (HSDB)
- Uses: REPORTED USES IN NON-ALCOHOLIC BEVERAGES, ICE CREAM, ICES, CANDY, BAKED GOODS, GELATINS, PUDDINGS, AND CHEWING GUM. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| EMBL-EBI ChEBI | Exact match | 2026-08-31 |
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.