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CAS 1 record

CAS 104-55-2

CAS 104-55-2 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 104-55-2
CAS 104-55-2PubChem CID 637511

Cinnamaldehyde

(E)-cinnamaldehyde is the E (trans) stereoisomer of cinnamaldehyde, the parent of the class of cinnamaldehydes. It has a role as a sensitiser, a hypoglycemic agent, a flavouring agent, a vasodilator agent, an antifungal agent, an EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor and a plant metabolite. It is a 3-phenylprop-2-enal and a member of cinnamaldehydes. — ChEBI

IUPAC name
(E)-3-phenylprop-2-enal
Molecular formula
C9H8O
Molecular weight
132.16 g/mol
Exact mass
132.057514874 Da
XLogP3
1.9
Topological polar surface area
17.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

ZimtaldehydeCinnamal3-Phenylacrylaldehyde2-Propenal, 3-phenyl-Phenylacrolein3-Phenylpropenal3-Phenyl-2-propenalCassia aldehyde
16 more reported names
Cinnamylaldehyde3-Phenylacrolein(E)-3-Phenyl-2-propenalCinnemaldehydeCinnamyl aldehydeAbion CABenzylideneacetaldehydebeta-Phenylcrolein3-Fenylpropenal3-Phenyl-2-propenaldehyde3-Phenyl-2-propen-1-alAcrolein, 3-phenyl-FEMA No. 2286Aldehyd skoricovyNCI-C56111Hefty Dog and Cat Repellent
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:142921

3-phenylprop-2-enal

A member of the class of cinnamaldehydes that is prop-2-enal in which a hydrogen at position 3 has been replaced by a phenyl group. The configuration of the double bond is not specified; the name "cinnamaldehyde" is widely used to refer to the E (trans) isomer.

Formula
C9H8O
Average mass
132.162 g/mol
Monoisotopic mass
132.05751 Da
Formal charge
0
  • cinnamaldehydes — is a (CHEBI:23245)
  • cinnamaldehydes — is a (CHEBI:23245)
Additional curated names
3-phenylacrylaldehyde3-phenylpropenal
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2019-01-16. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match637511

Attributed physical-property, hazard, environmental and use annotations.

  • Substance: trans-Cinnamaldehyde Source: NTP Technical Reports
  • NTP Technical Report: TR-514: Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14371-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) (2004 ) Source: NTP Technical Reports
  • Peer Review Date: 09/05/02 Source: NTP Technical Reports
  • Conclusion for Male Rat: No Evidence Source: NTP Technical Reports
  • Conclusion for Female Rat: No Evidence Source: NTP Technical Reports
  • Conclusion for Male Mice: No Evidence Source: NTP Technical Reports
  • Conclusion for Female Mice: No Evidence Source: NTP Technical Reports
  • Summary: Under the conditions of this 2-year feed study, there was no evidence of carcinogenic activity of transcinnamaldehyde in male or female F344/N rats exposed to 1,000, 2,100, or 4,100 ppm. There was no evidence of carcinogenic activity of trans-cinnamaldehyde in male or female B6C3F1 mice exposed to 1,000, 2,100, or 4,100 ppm.; Exposure to trans-cinnamaldehyde resulted in olfactory epithelial pigmentation in male and female mice. Source: NTP Technical Reports
  • Carcinogen Classification: No indication of carcinogenicity to humans (not listed by IARC). Source: Toxin and Toxin Target Database (T3DB)
  • Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H317: May cause an allergic skin reaction [Warning Sensitization, Skin] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P261, P272, P280, P302+P352, P321, P333+P317, P362+P364, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 0.2% (5 of 2854) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H312 (76%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H315 (98.1%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (99.7%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (95.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P272, P280, P302+P352, P305+P351+P338, P317, P321, P332+P317, P333+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2854 reports by companies from 40 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 5 of 2854 reports by companies.; There are 39 notifications provided by 2849 of 2854 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Note: This chemical does not meet GHS hazard criteria for 1.9% (3 of 161) of reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H312 (65.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H315 (98.1%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (98.1%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (98.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (94.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H412 (64.6%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P271, P272, P273, P280, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 161 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 3 of 161 reports by companies.; There are 11 notifications provided by 158 of 161 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Toxicity Summary: Cinnamaldehyde is an allergen. The physiologic effect of cinnamaldehyde is by means of increased histamine release and cell-mediated immunity. Source: Toxin and Toxin Target Database (T3DB)
  • Environmental Bioconcentration: An estimated BCF of 8 was calculated in fish for cinnamaldehyde(SRC), using a log Kow of 1.9(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 37(SRC), determined from a log Kow of 1.9(2) and a regression-derived equation(3), indicates that cinnamaldehyde is expected to have very high mobility in soil(SRC). Volatilization of cinnamaldehyde from moist soil surfaces may be an important fate process(SRC) given an estimated Henry's Law constant of 3.5X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 2.89X10-2 mm Hg(4), and water solubility, 1,420 mg/L(5). Cinnamaldehyde is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Biodegradation data were not available(SRC, 2009). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 37(SRC), determined from a log Kow of 1.9(2) and a regression-derived equation(3), indicates that cinnamaldehyde is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.5X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 2.89X10-2 mm Hg(4), and water solubility, 1,420 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 290 hours and 91 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 8(SRC), from its log Kow (2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Biodegradation data were not available(SRC, 2009). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cinnamaldehyde, which has a vapor pressure of 2.89X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase cinnamaldehyde is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 10 hours and 9.5 hours for the cis- and trans-isomers, respectively(SRC), calculated from its rate constant of 3.8X10-11 and 4.0X10-11 cu cm/molecule-sec at 25 °C for cis- and trans-isomers, respectively(SRC). Cinnamaldehyde does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Flavoring and nutrient; Not Known or Reasonably Ascertainable; Soil amendments (fertilizers); Fragrance; Processing aids, specific to petroleum production Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Processing aids, specific to petroleum production; Soil amendments (fertilizers); Fixing agent (mordant); Fragrance; Flavoring and nutrient; Solvent Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 104-55-2

1 total
Annex
III
Entry
76

Cinnamal

2-Propenal, 3-phenyl-

The presence of the substance must be indicated in the list of ingredients referred to in Article 6(1)g when its concentration exceeds: - 0.001% in leave-on products - 0.01% in rinse-off products

EC
203-213-9

How CAS 104-55-2 is used on this site

CAS 104-55-2 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

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A substance identified by CAS 104-55-2 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

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