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CAS 1 record

CAS 101-61-1

CAS 101-61-1 matches 1 EU annex record across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 101-61-1
CAS 101-61-1PubChem CID 7567

Bis(p-(dimethylamino)phenyl)methane

4,4'-Methylenebis(N,N-dimethylaniline) is a diarylmethane. — ChEBI

IUPAC name
4-[[4-(dimethylamino)phenyl]methyl]-N,N-dimethylaniline
Molecular formula
C17H22N2
Molecular weight
254.37 g/mol
Exact mass
254.178298710 Da
XLogP3
3.9
Topological polar surface area
6.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

4,4'-Methylenebis(N,N-dimethylaniline)Michler's baseMethane baseBis[4-(dimethylamino)phenyl]methaneMichler's hydrideMethylene baseMichler's methaneReduced michler'S ketone
16 more reported names
4,4'-Bis(dimethylamino)diphenylmethaneArnold's baseTetramethyldiaminodiphenylmethaneBis(4-(N,N-dimethylamino)phenyl)methane4,4'-TetramethyldiaminodiphenylmethaneBaze michlerova4,4'-Methylenebis(N,N-dimethyl)benzenamine4,4'-(Dimethylamino)diphenylmethanep,p-Dimethylaminodiphenylmethanep,p'-Bis(dimethylamino)diphenylmethaneNCI-C01990Diphenylmethane, tetramethyldiamino-p,p-TetramethyldiaminodiphenylmethaneN,N'-Tetramethyldiaminodiphenylmethane4,4'-Methylenebis(N,N-dimethylbenzenamine)BAZE michlerova [Czech]
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:34370

4,4'-Methylenebis(N,N-dimethylaniline)

Formula
C17H22N2
Average mass
254.377 g/mol
Monoisotopic mass
254.17830 Da
Formal charge
0
  • diarylmethane — is a (CHEBI:51614)
  • diarylmethane — is a (CHEBI:51614)
Additional curated names
4,4'-Methylenebis(N,N-dimethylaniline)Michler's base
Cross-references from this source
  • CAS: 101-61-1 — KEGG COMPOUND
  • MANUAL_X_REF: C14135 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-07-28. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7567

Attributed physical-property, hazard, environmental and use annotations.

  • Density: 1.14 at 68 °F (NTP, 1992) - Denser than water; will sink Source: CAMEO Chemicals
  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H350 (100%): May cause cancer [Danger Carcinogenicity]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P273, P280, P318, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 46 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P280, P318, P319, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H303: May be harmful if swallowed [Warning Acute toxicity, oral]; H351: Suspected of causing cancer [Warning Carcinogenicity] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P280, P301+P317, P318, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Environmental Bioconcentration: Bis(p-(dimethylamino)phenyl)methane, present at 0.50 and 0.050 mg/L resulted in BCF of 629 and 423, respectively, in fish using carp (Cyprinus carpio) which were exposed over an 4-week period(1). According to a classification scheme(2), these BCF values suggest that bioconcentration in aquatic organisms is high(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a log Koc of 3.26(2) (Koc of 9,100(SRC)), determined from a structure estimation method(2), indicates that bis(p-(dimethylamino)phenyl)methane is expected to be immobile in soil(SRC). Volatilization of bis(p-(dimethylamino)phenyl)methane from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.2X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Bis(p-(dimethylamino)phenyl)methane is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 3.3X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(4). A 0% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a log Koc of 3.26(2) (Koc of 9,100(SRC)), determined from a structure estimation method(2), indicates that bis(p-(dimethylamino)phenyl)methane is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.2X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), BCF values of 423 and 629(8), suggest that bioconcentration in aquatic organisms is high(SRC). A 0% of theoretical BOD using activated sludge in the Japanese MITI test(6) suggests that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), bis(p-(dimethylamino)phenyl)methane, which has an estimated vapor pressure of 3.3X10-6 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase bis(p-(dimethylamino)phenyl)methane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1 hour(SRC), calculated from its rate constant of 2.1X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase bis(p-dimethylamino)phenyl)methane may be removed from the air by wet or dry deposition(SRC). Bis(p-dimethylamino)phenyl)methane does not contain chromophores that absorb at wavelengths >290 nm(4), and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 101-61-1

1 total

How CAS 101-61-1 is used on this site

CAS 101-61-1 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 1 EU annex record shares this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 101-61-1 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.

Frequently asked questions

A substance identified by CAS 101-61-1 may appear in multiple EU cosmetic regulation annexes when it is subject to different conditions in different contexts. For example, a substance might be restricted under Annex III with specific conditions, and the same CAS might also appear in Annex IV as an approved colorant under separate entry conditions. Each entry must be reviewed individually.

Cross-reference the CAS number against your raw material specification sheets and CoA documents. When a CAS appears in Annex II, verify absence. When it appears in Annex III, verify that concentration limits and product type conditions are met in your formulation. All annex entries sharing this CAS number are listed above.

A CAS number is assigned by the Chemical Abstracts Service (USA) and is globally recognised. An EC number is a European Commission identifier from inventories such as EINECS, ELINCS or the NLP list. Both identifiers may appear in EU cosmetic annex entries. Some substances have both, some have only one, and some older entries may have neither.

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