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CAS 10049-04-4

CAS 10049-04-4 matches 0 EU annex records across Annex II–VI of Regulation 1223/2009.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 10049-04-4
CAS 10049-04-4PubChem CID 24870

Chlorine Dioxide

Dioxidochlorine(.) is a chlorine dioxide. — ChEBI

Molecular formula
ClO2
Molecular weight
67.45 g/mol
Exact mass
66.9586819 Da
XLogP3
1.4
Topological polar surface area
18.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

AlcideChlorine oxide (ClO2)Chlorine(IV) oxidePuriteJoydenJoyden plusNobda disinfectantBlueMAX Pre-Post
16 more reported names
Gladiator Super DryBlueMAX Premium EURefChem:5668SKIN N CLEANVIRUS ZERO-FProVtect Hand SanitizerChlorine Dioxide(ClO2)SANI-HEALTH SanitizerPURE O2 SVIRUS KILL SANITIZERPURE O2-S FChlorine dioxide disinfectantM.C. (Morningcalm) V ZeroDMINE PENTOSE MEDI PLUS8061YMS4RMJiajia Gaseous Air Disinfectant
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:29415

dioxidochlorine(•)

Formula
ClO2
Average mass
67.451 g/mol
Monoisotopic mass
66.95868 Da
Formal charge
0
  • chlorine dioxide — is a (CHEBI:52357)
  • chlorine dioxide — is a (CHEBI:52357)
Additional curated names
dioxidochlorine(.)dioxido-lambda(5)-chloranylchlorine dioxideChlorine peroxide[ClO2](.)(OClO)(.)O2Cl(.)
Cross-references from this source
  • CAS: 10049-04-4 — NIST Chemistry WebBook
  • CAS: 10049-04-4 — KEGG COMPOUND
  • REGISTRY_NUMBER: 1265 — Gmelin
  • MANUAL_X_REF: C18368 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-08-03. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match24870

Attributed physical-property, hazard, environmental and use annotations.

  • Physical Description: Chlorine dioxide hydrate, frozen is an orange colored solid, appearing as a block of ice, with a faint odor of chlorine. It may only be shipped in the frozen state and then only by private or contract motor carrier. The melting point of the hydrate is around 30 °F. If it should thaw and further warm up, chlorine dioxide gas is given off. The gas is toxic by inhalation. The gas and liquid are violently decomposed by organic materials. The gas will decompose explosively at temperatures below the boiling point of water. It is used to bleach wood pulp, fats and oils; in processing flour, and for water purification. Chlorine dioxide is a yellow to reddish gas or a red-brown liquid below 52 deg. F. with an unpleasant odor similar to chlorine. Source: CAMEO Chemicals
  • Physical Description: Liquid; Gas Vapor Source: EPA Chemical Data Reporting (CDR)
  • Physical Description: Yellow to red gas or a red-brown liquid (below 52 degrees F) with an unpleasant odor similar to chlorine and nitric acid; [NIOSH] Vapor density = 2.3 (heavier than air); [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Physical Description: Liquid Source: Human Metabolome Database (HMDB)
  • Physical Description: RED-YELLOW GAS WITH PUNGENT ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
  • Physical Description: Yellow to red gas or a red-brown liquid (below 52 °F) with an unpleasant odor similar to chlorine and nitric acid. Source: Occupational Safety and Health Administration (OSHA)
  • Physical Description: Yellow to red gas or a red-brown liquid (below 52 °F) with an unpleasant odor similar to chlorine and nitric acid. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • First Aid: Excerpt from NIOSH Pocket Guide for Chlorine dioxide:; Eye: IRRIGATE IMMEDIATELY (LIQUID) - If this chemical in liquid form contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: SOAP WASH IMMEDIATELY (LIQUID) - If this chemical in liquid form contacts the skin, immediately wash the contaminated skin with soap and water. If this chemical penetrates the clothing, immediately remove the clothing, wash the skin with soap and water, and get medical attention promptly.; Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.; Swallow: MEDICAL ATTENTION IMMEDIATELY (LIQUID) - If this chemical in liquid form has been swallowed, get medical attention immediately. (NIOSH, 2024) Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately (liquid); Skin: Soap wash immediately (liquid); Breathing: Respiratory support; Swallow: Medical attention immediately (liquid) Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H270: May cause or intensify fire; oxidizer [Danger Oxidizing gases]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H330: Fatal if inhaled [Danger Acute toxicity, inhalation]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P220, P244, P260, P264, P271, P273, P280, P284, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P320, P321, P363, P370+P376, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P260, P264, P270, P273, P280, P301+P316, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H270 (29.9%): May cause or intensify fire; oxidizer [Danger Oxidizing gases]; H280 (29.2%): Contains gas under pressure; may explode if heated [Warning Gases under pressure]; H301 (72.1%): Toxic if swallowed [Danger Acute toxicity, oral]; H314 (76.2%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (46.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (24%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H330 (29.9%): Fatal if inhaled [Danger Acute toxicity, inhalation]; H332 (15.9%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H400 (76.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P220, P244, P260, P261, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P301+P330+P331, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P320, P321, P330, P337+P317, P363, P370+P376, P391, P403, P403+P233, P405, P410+P403, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 542 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] Source: NITE-CMC
  • Precautionary Statement Codes: P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Toxicity Summary: IDENTIFICATION AND USE: Chlorine dioxide is a yellowish-brown gas with unpleasant odor similar to chlorine and nitric acid. Its uses include bleaching cellulose, paper-pulp, flour, leather, fats and oils, textiles, and beeswax. It is also used for purification of water, taste and odor control of water, cleaning and detanning leather, in the manufacture of chloride salts, and as an oxidizing agent, bactericide, antiseptic and deodorizer. Chlorine dioxide was found to be highly effective against various microorganisms tested at very low concentrations in a minimum contact time of 30 to 60 seconds. HUMAN STUDIES: Potential symptoms of overexposure are irritation of eyes, nose, and throat, as well as coughing, wheezing, bronchitis, and pulmonary edema. Workers industrially exposed to low concentrations of the gas in air have been noted occasionally to suffer from irritation of the eyes and to see haloes about lights, but these effects have been minor compared to respiratory irritation. Bronchoscopy and biopsy revealed slight chronic bronchitis in 7 of 12 workers. Only two workers who had been exposed just prior to examination showed physical signs of respiratory effects. Workers acutel Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: Hydrogen peroxide (H2O2), chlorite, chlorate, Cl2O3, oxygen (O2), and chlorine have all been reported as intermediates or products /of chlorine dioxide breakdown/. Presumably chlorine dioxide will not persist in open basins or reservoirs, although it can remain for days in clean distribution systems. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: It is generally accepted that the predominant reaction product of chlorine dioxide in water treatment is chlorite and that chlorate and other ions are produced in minor amounts ... an approximately 50% conversion of chlorine dioxide to chlorite was reported ... /in/ water containing natural humic acids. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: Chlorine dioxide does not cause formation of trihalomethanes, does not react with ammonia, and does not cause formation of chloramines. It can ... disproportionate to chlorate and chlorite ... by raising pH to 11 or 12 ... this is not believed to be an important reaction in water undergoing treatment. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: /Products formed during oxidative treatment of water/: both oxygenated and chlorinated products may be formed, the latter being found most prominently in connection with reactions of phenolic substances. Other products that might affect health are quinones and 1,2-epoxy compounds. Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used in bleaching wood pulp (95% of use); Also used in bleaching textiles; disinfecting hospital equipment; disinfecting fruits, vegetables, and meats; and treating municipal water; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Pulp and Paper Processing [Category: Industry]; Textiles (Fiber & Fabric Manufacturing) [Category: Industry]; Using Disinfectants or Biocides [Category: Clean]; Sewer and Wastewater Treatment [Category: Industry]; Toxic Gas from Spilling Chemical in Water [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: For chlorine dioxide (USEPA/OPP Pesticide Code: 020503) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Bleaching cellulose, paper-pulp, flour, leather, fats and oils, textiles, beeswax; purification of water; taste and odor control of water; cleaning and detanning leather; manufacture of chloride salts; oxidizing agent; bactericide, antiseptic and deodorizer. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: The agricultural premises and equipment uses include the disinfection of hard surfaces and equipment (such as hatching facilities and mushroom houses) and water systems (such as chiller water and humidification water in poultry houses). Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Commercial, industrial, and medical uses include disinfection of ventilation systems, hard surfaces (e.g., floors, walls, and laboratory equipment), water systems, pulp/paper mills, and food rinses. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for Chlorine dioxide (7 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Records for CAS 10049-04-4

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How CAS 10049-04-4 is used on this site

CAS 10049-04-4 is the Chemical Abstracts Service identifier used to pin this page to a specific substance. In the current dataset, 0 EU annex records share this identifier, which helps you cross-check whether the same substance appears under one regulatory context or several.

Use this page when a supplier specification, SDS or raw-material dossier gives you CAS 10049-04-4 and you need to see every linked Annex II–VI record in one place. The entry cards above are the quickest route to concentration limits, warnings, annex placement and product-type conditions.