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Annex IV Entry 57 14/08/2020

Ethyl 8'-apo-.beta.-caroten-8'-oate

CI 40825

Ethyl 8'-apo-.beta.-caroten-8'-oate appears in Annex IV as a positive-list colorant entry for EU cosmetics.

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Permitted colorant— Annex IV, EU Regulation 1223/2009
Entry: 57

Chemical identity and properties

PubChem 2D chemical structure for CAS 1109-11-1
CAS 1109-11-1PubChem CID 6391647

Ethyl beta-apo-8'-carotenoate

IUPAC name
ethyl (2E,4E,6E,8E,10E,12E,14E,16E)-2,6,11,15-tetramethyl-17-(2,6,6-trimethylcyclohexen-1-yl)heptadeca-2,4,6,8,10,12,14,16-octaenoate
Molecular formula
C32H44O2
Molecular weight
460.7 g/mol
Exact mass
460.334130642 Da
XLogP3
10.1
Topological polar surface area
26.3 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

8'-Apo-beta, psi-carotenoid acid, ethyl esterRefChem:596131214-173-7Food orange 7Ethyl 8'-apo-caroten-8'-oateEthyl 8'-apo-beta-caroten-8'-oateETHYL BETA-APO-8/'-CAROTENOATE (TRANS)ethyl (2E,4E,6E,8E,10E,12E,14E,16E)-2,6,11,15-tetramethyl-17-(2,6,6-trimethylcyclohex-1-en-1-yl)heptadeca-2,4,6,8,10,12,14,16-octaenoate
12 more reported names
(2E,4E,6E,8E,10E,12E,14E,16E)-Ethyl 2,6,11,15-tetramethyl-17-(2,6,6-trimethylcyclohex-1-en-1-yl)heptadeca-2,4,6,8,10,12,14,16-octaenoatebeta-Apo-8'-carotenoic acid, ethyl esterEINECS 214-173-7CI 40825Ethyl 8'-apo-beta, psi-carotenoateC32H44O2GIRXTOSJOKKBHO-BQTUIHPCSA-NEthyl 8'-apo-b-caroten-8'-oateHY-D0313CS-0010253Ethyl |_-apo-8 inverted exclamation marka-carotenoateEthyl |A-Apo-8 inverted exclamation marka-Carotenoate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match6391647

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 99% (104 of 105) of all reports. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 104 of 105 companies (only 1% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 105 reports by companies from 2 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 104 of 105 reports by companies.; There is 1 notification provided by 1 of 105 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Warnings

Purity criteria as set out in Commission Directive 95/45/EC (E 160f)

Colour index or glossary

CI 40825

Chemical name

Ethyl 8'-apo-.beta.-caroten-8'-oate

Chemical / IUPAC name

Ethyl 8'-apo-.beta.-caroten-8'-oate; CI 40825

Color

Orange

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

Identified ingredients

Key data

CAS
1109-11-1
EC
214-173-7
Annex
IV
Entry number
57

Inventory links for Ethyl 8'-apo-.beta.-caroten-8'-oate

Inventory Restriction reference
Ref 32750

CI 40825

CAS: 1109-11-1
EC: 214-173-7

Direct matches are limited for this record, so nearby entries from Annex IV are shown as well.

Annex IV 56
Nearby record in the same annex

CI 40820

CAS: 1962-15-8
EC: 214-171-6
Annex IV 58
Nearby record in the same annex

CI 40850

CAS: 514-78-3
EC: 208-187-2
Annex IV 55
Nearby record in the same annex

CI 40800

CAS: 116-32-5; 31797-85-0; 7235-40-7
EC: 230-636-6
Annex IV 54
Nearby record in the same annex

CI 40215

CAS: 1325-54-8
EC: 215-397-8
Annex IV 53
Nearby record in the same annex

CI 28440

CAS: 2519-30-4
EC: 219-746-5
Annex IV 52
Nearby record in the same annex

CI 27755

CAS: 2118-39-0
EC: 218-326-9
Annex IV 62
Nearby record in the same annex

CI 42080

CAS: 3486-30-4
EC: 222-476-0

What Annex IV means for Ethyl 8'-apo-.beta.-caroten-8'-oate

Ethyl 8'-apo-.beta.-caroten-8'-oate is an approved colorant listed in Annex IV of EU Cosmetics Regulation 1223/2009. Only colorants on this positive list may be used to colour cosmetic products on the EU market.

Some colorants in Annex IV are restricted by product type — for example, prohibited from use around the eyes or in products applied to mucous membranes. Check the product type and conditions fields above before use.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Confirm colorant is used only in permitted product types listed above.
  • Record the Colour Index number and CAS identifier in the ingredient declaration.

Frequently asked questions

Yes. Ethyl 8'-apo-.beta.-caroten-8'-oate is included in Annex IV of EU Cosmetics Regulation 1223/2009 as a permitted colorant. Only colorants on this positive list may be used to colour cosmetic products in the EU. Check the product type conditions above for any use restrictions.

CAS 1109-11-1 is the unique numerical identifier assigned to Ethyl 8'-apo-.beta.-caroten-8'-oate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex IV record Ethyl 8'-apo-.beta.-caroten-8'-oate

This page summarizes one Annex IV record for Ethyl 8'-apo-.beta.-caroten-8'-oate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex IV conditions for Ethyl 8'-apo-.beta.-caroten-8'-oate, but confirm any final regulatory decision against the current official annex wording and source files.

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