What is CAS 12001-28-4 for Crocidolite?

CAS 12001-28-4 is the unique numerical identifier assigned to Crocidolite by the Chemical Abstracts Service. It is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports.

Annex II Entry 762 CMR24/11/2016

Crocidolite

Q: How do I check if my product formula contains Crocidolite?

Use the INCI Checker tool on CosIng Checker to paste your full ingredient list and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records.

Crocidolite is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Search similar Back to annex Compare

Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 762

CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 12001-28-4

CAS 12001-28-4PubChem CID 86278622

Crocidolite Asbestos

Asbestos is a slender, fine, flaxy fiber. Long term occupational exposure to the dust can result in lung cancer. Asbestos is resistant to fire and most solvents. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is used as a heat resistant material, in cement, furnace bricks, and brake linings. — CAMEO Chemicals

IUPAC name: trimagnesium;disodium;octakis(dihydroxy(oxo)silane);bis(iron(3+))

Molecular formula: Fe2H16Mg3Na2O24Si8+14
Molecular weight: 855.38 g/mol
Exact mass: 853.623098 Da
Topological polar surface area: 460.0 Å²
Hydrogen-bond donors: 16
Hydrogen-bond acceptors: 24
Covalent units: 15
Defined stereocentres: 0

Also known as

Blue AsbestosASBESTOS, CROCIDOLITECK28D16OLZAsbestos, BlueAsbestos-crocidoliteRefChem:51ASBESTOS, (BLUE)CHEBI:46666

16 more reported names

CrocidoliteKrokydolithCrocidolite uiccMagnesioriebeckiteRiebeckite asbestosCrocidolite (9CI)Krokydolith [German]Magnesioriebackite asbestosCrocidolite [Asbestos]trimagnesium;disodium;dihydroxy(oxo)silane;iron(3+)CROCIDOLITEASBESTOSAsbestos, magnesioriebeckiteFibrous crocidolite asbestosAmorphous crocidolite asbestosCCRIS 362NCI C09007

Open full PubChem record PubChem annotations 3D structure image

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match86278622

Attributed physical-property, hazard, environmental and use annotations.

Boiling Point: Decomposes (NIOSH, 2024) Source: CAMEO Chemicals
Boiling Point: decomposes Source: Occupational Safety and Health Administration (OSHA)

Density: Relative density (water = 1): 3.3-3.4 Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Melting Point: 1112 °F (Decomposes) (NIOSH, 2024) Source: CAMEO Chemicals
Melting Point: 1112 °F (decomposes) Source: Occupational Safety and Health Administration (OSHA)

Physical Description: Asbestos is a slender, fine, flaxy fiber. Long term occupational exposure to the dust can result in lung cancer. Asbestos is resistant to fire and most solvents. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is used as a heat resistant material, in cement, furnace bricks, and brake linings. Source: CAMEO Chemicals
Physical Description: LAVENDER, BLUE OR GREENISH FIBROUS SOLID. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Physical Description: Blue fibrous, odorless solid. Source: Occupational Safety and Health Administration (OSHA)

Solubility: Insoluble (NIOSH, 2024) Source: CAMEO Chemicals
Solubility: Solubility in water: none Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Vapor Pressure: 0 mmHg (approx) (NIOSH, 2024) Source: CAMEO Chemicals
Vapor Pressure: 0 mmHg (approx) Source: Occupational Safety and Health Administration (OSHA)

Substance: Asbestos, crocidolite Source: NTP Technical Reports
NTP Technical Report: TR-280: Toxicology and Carcinogenesis Studies of Crocidolite Asbestos (CASRN 12001-28-4) In F344/N Rats (Feed Studies) (1988 ) Source: NTP Technical Reports
Peer Review Date: 02/28/83 Source: NTP Technical Reports
Conclusion for Male Rat: No Evidence Source: NTP Technical Reports
Conclusion for Female Rat: No Evidence Source: NTP Technical Reports
Conclusion for Male Mice: Chemical Not Tested in Species/Sex Source: NTP Technical Reports
Conclusion for Female Mice: Chemical Not Tested in Species/Sex Source: NTP Technical Reports
Summary: Under the conditions of these feed studies, crocidolite asbestos was not overtly toxic and did not cause a carcinogenic response when ingested at a concentration of 1% in the diet by male and female F344/N rats for their lifetime. Source: NTP Technical Reports
Carcinogen Classification: 1, carcinogenic to humans. (L224) Source: Toxin and Toxin Target Database (T3DB)

Exposure Routes: Exposure mainly occurs via inhalation. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Exposure Routes: Inhalation (L222) ; injection (L222) Source: Toxin and Toxin Target Database (T3DB)

First Aid: Excerpt from NIOSH Pocket Guide for Asbestos:; Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Breathing: FRESH AIR - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. Other measures are usually unnecessary. (NIOSH, 2024) Source: CAMEO Chemicals

Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity]; H372 **: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P203, P260, P264, P270, P280, P318, P319, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Danger Source: NITE-CMC
GHS Hazard Statements: H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
Precautionary Statement Codes: P203, P260, P264, P270, P280, P308+P316, P318, P319, P321, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
GHS Hazard Statements: H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
Precautionary Statement Codes: P203, P260, P261, P264, P270, P271, P280, P304+P340, P318, P319, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
Signal: Danger Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
GHS Hazard Statements: H350: May cause cancer [Danger Carcinogenicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Precautionary Statement Codes: P203, P260, P264, P270, P280, P318, P319, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Health Effects: Infected people develop a slow buildup of scar-like tissue in the lungs and in the membrane that surrounds the lungs, so breathing becomes difficult. Blood flow to the lung may also be decreased, and this causes the heart to enlarge. This disease is called asbestosis. Infected people have increased chances of getting two principal types of cancer: cancer of the lung tissue itself and mesothelioma, a cancer of the thin membrane that surrounds the lung and other internal organs. The cellular immune system of the patient can be depressed. Also, deletions of chromosome segments have been noted in human mesothelioma cells or cell lines. (L222) Source: Toxin and Toxin Target Database (T3DB)

Toxicity Summary: When asbestos fibers are inhaled, many are deposited on the epithelial surface of the respiratory tree. Fibers that are retained in the lung or mesothelium for long periods of time are capable of producing chronic inflammation and fibrotic and tumorigenic effects. These effects may be mediated by direct interactions between the fiber and key cellular macromolecules, or they may be mediated by the production of reactive oxygen species and other cellular factors originating from alveolar macrophages. In addition, the physical-chemical nature of the fiber appears to be an important determinant of toxicity. It is generally agreed that exposure to amphibole fibers can produce mesothelioma, and that the potency of amphibole fibers to produce mesothelioma is greater than that of chrysotile. Asbestos fibers can adsorb to a variety of cellular macromolecules (e.g., proteins,membrane lipids, RNA, DNA). The coulombic forces between the asbestos fiber and some of these macromolecules may induce conformational changes, and these changes could affect protein function and chromosomal fidelity. Fibers found to be translocated near the nucleus can interact with the cytoskeleton and interfere with c Source: Toxin and Toxin Target Database (T3DB)

Uses: Asbestos are used in building materials (roofing shingles, ceiling and floor tiles, paper products, and asbestos cement products), friction products (automobile clutch, brake, and transmission parts), heat-resistant fabrics, packaging, gaskets, and coatings. Some vermiculite or talc products may contain asbestos. Exposure most likely by breathing air containing asbestos fibers or by drinking asbestos fibers that are present in water. (L222) Source: Toxin and Toxin Target Database (T3DB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Crocidolite

Chemical / IUPAC name

Crocidolite

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

Category	Carcinogenic	Mutagenic	Reprotoxic
Cat. 1A	✓	—	—

Key data

CAS

12001-28-4

601-649-8

Annex

Entry number

762

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 761