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Annex II Entry 755 CMR24/11/2016

(+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO)

(+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 755
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 119738-06-6
CAS 119738-06-6PubChem CID 86175

Quizalofop-tefuryl

IUPAC name
oxolan-2-ylmethyl 2-[4-(6-chloroquinoxalin-2-yl)oxyphenoxy]propanoate
Molecular formula
C22H21ClN2O5
Molecular weight
428.9 g/mol
Exact mass
428.1138995 Da
XLogP3
4.3
Topological polar surface area
79.8 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
7
Covalent units
1
Defined stereocentres
0

Also known as

EB75I82DU0QUIZALOFOP-P TEFURYL ESTERUBI-1956Propanoic acid, 2-[4-[(6-chloro-2-quinoxalinyl)oxy]phenoxy]-, (tetrahydro-2-furanyl)methyl esterPropanoic acid, 2-(4-((6-chloro-2-quinoxalinyl)oxy)phenoxy)-, (tetrahydro-2-furanyl)methyl esterRefChem:178398601-628-3EC 414-200-4
11 more reported names
C 4874UNII-EB75I82DU0(2R)-(Tetrahydrofuran-2-yl)methyl 2-(4-((6-chloroquinoxalin-2-yl)oxy)phenoxy)propanoateUBI-C 4874[(2R)-oxolan-2-yl]methyl 2-{4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy}propanoate(2R)-2-[4-[(6-chloro-2-quinoxalinyl)oxy]phenoxy]propanoic acid [(2S)-2-oxolanyl]methyl ester(+/-) Tetrahydrofurfuryl (R)-2-(4-(6-chloroquinoxalin-2-yloxy)phenyloxy)propionateAS-16082(Oxolan-2-yl)methyl 2-{4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy}propanoate2-tetrahydrofuranylmethyl 2-[4-(6-chloro-2-quinoxalinyloxy)phenoxy]propanoatetetrahydrofuran-2-ylmethyl 2-[4-(6-chloroquinoxalin-2-yl)oxyphenoxy]propanoate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match86175

Attributed physical-property, hazard, environmental and use annotations.

  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]; H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P264, P270, P273, P280, P301+P317, P318, P319, P330, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 54 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H361fd: Suspected of damaging fertility; Suspected of damaging the unborn child [Warning Reproductive toxicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
  • Precautionary Statement Codes: P203, P260, P264, P270, P273, P280, P301+P317, P318, P319, P330, P391, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

(+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO)

Chemical / IUPAC name

(+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO)

Regulatory information

Regulation

(EC) 2009/1223

See every entry this act set

SCCS opinions

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B——✓
Cat. 2—✓—

Key data

CAS
119738-06-6
EC
414-200-4
Annex
II
Entry number
755

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 753
Nearby record in the same annex

Sulfallate

CAS: 95-06-7
EC: 202-388-9

What Annex II means for (+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO)

(+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. (+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO) is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 119738-06-6 is the unique numerical identifier assigned to (+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO) by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

(+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO) has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record (+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO)

This page summarizes one Annex II record for (+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for (+/-)-Tetrahydrofurfuryl -(R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenyloxy]propionate (Quizalofop-P-tefuryl - ISO), but confirm any final regulatory decision against the current official annex wording and source files.

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