3,3'-Dichlorobenzidine dihydrogen bis(sulphate)
3,3'-Dichlorobenzidine dihydrogen bis(sulphate) is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
3,3'-Dichlorobenzidine sulfate
3,3'-dichlorobenzidine sulfate appears as a white crystalline powder. Toxic by ingestion and skin absorption. — CAMEO Chemicals
- IUPAC name
- 4-(4-amino-3-chlorophenyl)-2-chloroaniline;sulfuric acid
- Molecular formula
- C12H14Cl2N2O8S2
- Molecular weight
- 449.3 g/mol
- Exact mass
- 447.9568631 Da
- Topological polar surface area
- 218.0 Ų
- Hydrogen-bond donors
- 6
- Hydrogen-bond acceptors
- 10
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
2 more reported names
External database identifiers
- EPA DTXSID:DTXSID80886703
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
3,3'-Dichlorobenzidine dihydrogen bis(sulphate)
Regulatory information
SCCS opinions
- Opinion concerning Chemical Ingredients in Cosmetic Products classified as Carcinogenic, Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EECC
- Opinion concerning Chemical Ingredients in Cosmetic Products classified as Carcinogenic, Mutagenic or Toxic to Reproduction according to the Chemicals Directive 67/548/EEC
Key data
Related records for 3,3'-Dichlorobenzidine dihydrogen bis(sulphate)
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
3,3'-Dichlorobenzidine sulphate
3,3'-Dichlorobenzidine dihydrochloride
4,4'-Bi-o-toluidine (ortho-Tolidine)
[[1,1'-Biphenyl]-4,4'-diyl]diammonium sulphate
4,4'-Bi-o-toluidine dihydrochloride
[3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl]diammonium bis(hydrogen sulphate)
4,4'-Bi-o-toluidine sulphate
What Annex II means for 3,3'-Dichlorobenzidine dihydrogen bis(sulphate)
3,3'-Dichlorobenzidine dihydrogen bis(sulphate) is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
Frequently asked questions
Source note for Annex II record 3,3'-Dichlorobenzidine dihydrogen bis(sulphate)
This page summarizes one Annex II record for 3,3'-Dichlorobenzidine dihydrogen bis(sulphate) from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for 3,3'-Dichlorobenzidine dihydrogen bis(sulphate), but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
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