Annex II Entry 1677 03/11/2021

Mesotrione (ISO); 2-[4-(methylsulfonyl)- 2-nitrobenzoyl]-1,3- cyclohexanedione

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Mesotrione (ISO); 2-[4-(methylsulfonyl)- 2-nitrobenzoyl]-1,3- cyclohexanedione is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009

Entry: 1677

Chemical identity and properties

PubChem 2D chemical structure for CAS 104206-82-8

CAS 104206-82-8PubChem CID 175967

Mesotrione

Mesotrione is an aromatic ketone that is cyclohexa-1,3-dione in which one of the hydrogens at position 2 is substituted by a 4-(methanesulfonyl)-2-nitrobenzoyl group. It has a role as a carotenoid biosynthesis inhibitor, a herbicide, a xenobiotic, an EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor and an environmental contaminant. It is a beta-triketone, a C-nitro compound, a sulfone and an aromatic ketone. It is functionally related to a benzophenone. — ChEBI

IUPAC name: 2-(4-methylsulfonyl-2-nitrobenzoyl)cyclohexane-1,3-dione

Molecular formula: C14H13NO7S
Molecular weight: 339.32 g/mol
Exact mass: 339.04127293 Da
XLogP3: 0.7
Topological polar surface area: 140.0 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 7
Covalent units: 1
Defined stereocentres: 0

Also known as

CHEBI:3832148TR68G21T(2-nitro-4-(methylsullfonyl))benzoylcyclohexane-1,3-dione1,3-Cyclohexanedione, 2-[4-(methylsulfonyl)-2-nitrobenzoyl]-ZA 12962-[4-(methylsulfonyl)-2-nitrobenzoyl]-1,3-cyclohexanedione2-(4-mesyl-2-nitrobenzoyl)cyclohexane-1,3-dione2-[4-(methanesulfonyl)-2-nitrobenzoyl]cyclohexane-1,3-dione

16 more reported names

1,3-Cyclohexanedione, 2-(4-(methylsulfonyl)-2-nitrobenzoyl)-2-(4-(METHYLSULFONYL)-2-NITROBENZOYL)-1,3-CYCLOHEXANEDIONE2-(4-(methanesulfonyl)-2-nitrobenzoyl)cyclohexane-1,3-dioneRefChem:156682mesotrione (ISO); 2-(4-(methylsulfonyl)-2-nitrobenzoyl)-1,3-cyclohexanedione600-533-42-(4-(Methylsulfonyl)-2-nitrobenzoyl)cyclohexane-1,3-dioneMesotrione [ISO]C14H13NO7S2-(4-methylsulphonyl-2-nitrobenzoyl)-1,3-cyclohexanedione2-(2'-nitro-4'-methylsulfonylbenzoyl)cyclohexane-1,3-dioneCallisto herbicideTenacity2-[4-(methylsulfonyl)-2-nitrobenzoyl]cyclohexane-1,3-dioneUNII-48TR68G21THSDB 7250

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:38321
ChEMBL:CHEMBL1873440
EPA DTXSID:DTXSID7032424
PubMed:40759372
PubMed:36914009
PubMed:34516295
PubMed:27384423
PubMed:22718431
PubMed:22696959
PubMed:22615921
PubMed:22463948
PubMed:22398691
PubMed:22319325
PubMed:22278807
PubMed:22245060

Evidence from additional scientific databases

EMBL-EBI ChEBI

Exact identifier matchCHEBI:38321

mesotrione

An aromatic ketone that is cyclohexa-1,3-dione in which one of the hydrogens at position 2 is substituted by a 4-(methanesulfonyl)-2-nitrobenzoyl group.

Formula: C14H13NO7S
Average mass: 339.325 g/mol
Monoisotopic mass: 339.04127 Da
Formal charge: 0

β-triketone — is a (CHEBI:140323)
aromatic ketone — is a (CHEBI:76224)
sulfone — is a (CHEBI:35850)
C-nitro compound — is a (CHEBI:35716)

EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor — has role (CHEBI:38317)
herbicide — has role (CHEBI:24527)
environmental contaminant — has role (CHEBI:78298)
xenobiotic — has role (CHEBI:35703)
carotenoid biosynthesis inhibitor — has role (CHEBI:138208)

benzophenone — has functional parent (CHEBI:41308)
EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor — has role (CHEBI:38317)
herbicide — has role (CHEBI:24527)
environmental contaminant — has role (CHEBI:78298)
xenobiotic — has role (CHEBI:35703)
carotenoid biosynthesis inhibitor — has role (CHEBI:138208)
β-triketone — is a (CHEBI:140323)
aromatic ketone — is a (CHEBI:76224)
sulfone — is a (CHEBI:35850)
C-nitro compound — is a (CHEBI:35716)

11455642 Source: PubMed
20692682 Source: PubMed

Additional curated names

2-[4-(methanesulfonyl)-2-nitrobenzoyl]cyclohexane-1,3-dione2-(2'-nitro-4'-methylsulfonylbenzoyl)cyclohexane-1,3-dione2-[4-(methylsulfonyl)-2-nitrobenzoyl]-1,3-cyclohexanedione2-(4-methylsulphonyl-2-nitrobenzoyl)-1,3-cyclohexanedione(2-nitro-4-(methylsullfonyl))benzoylcyclohexane-1,3-dione

Cross-references from this source

CAS: 104206-82-8 — ChemIDplus
MANUAL_X_REF: 442 — PPDB
MANUAL_X_REF: mesotrione — Alan Wood's Pesticides
MANUAL_X_REF: Mesotrione — Wikipedia
MANUAL_X_REF: WO2011016018 — Patent
REGISTRY_NUMBER: 8999656 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2018-03-04. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View

Exact identifier match175967

Attributed physical-property, hazard, environmental and use annotations.

Color/Form: Pale yellow solid Source: Hazardous Substances Data Bank (HSDB)
Color/Form: Opaque solid Source: Hazardous Substances Data Bank (HSDB)

Dissociation Constants: pKa = 3.12 at 20 °C; 0.6503 (associated) and 0.3404 (dissociated) Source: Hazardous Substances Data Bank (HSDB)

LogP: log Kow (at 20 °C): 0.11 (unbuffered water), 0.90 (pH 5), <-1.0 (pH 7 and pH 9) Source: Hazardous Substances Data Bank (HSDB)

Melting Point: 165 °C Source: Hazardous Substances Data Bank (HSDB)

Odor: Faint pleasant odor Source: Hazardous Substances Data Bank (HSDB)

Physical Description: Opaque solid; [Merck Index] Solid; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Solubility: In water, (g/L at 20 °C): 2.2 (pH 4.8); 15 (pH 6.9); 22 (pH 9); 0.16 (unbuffered water) Source: Hazardous Substances Data Bank (HSDB)
Solubility: Solubility in g/L at 20 °C): in acetonitrile 117.0, acetone 93.3, 1,2-dichloroethane 66.3, ethyl acetate 18.6, methanol 4.6, toluene 3.1, xylene 1.6, n-heptane <0.5 Source: Hazardous Substances Data Bank (HSDB)

Vapor Pressure: 0.00000004 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Vapor Pressure: <5.69X10-3 mPa /<4.27X10-8 mm Hg)/ at 20 °C Source: Hazardous Substances Data Bank (HSDB)

Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
GHS Hazard Statements: H361d: Suspected of damaging the unborn child [Warning Reproductive toxicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Precautionary Statement Codes: P203, P260, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H361 (19.3%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H361d (46.2%): Suspected of damaging the unborn child [Warning Reproductive toxicity]; H373 (64.5%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P203, P260, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 197 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
GHS Hazard Statements: H361d: Suspected of damaging the unborn child [Warning Reproductive toxicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Precautionary Statement Codes: P203, P260, P273, P280, P318, P319, P391, P405, and P501 (click each P-code to see the statement) Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Substances Data Bank (HSDB)

Toxicity Summary: IDENTIFICATION AND USE: Mesotrione is a pale yellow solid with a faint pleasant odor. Mesotrione is an herbicide used on field corn, seed corn, sweet corn, yellow popcorn, and grain sorghum. Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses. HUMAN EXPOSURE AND TOXICITY: Limited information is available on the effects of exposure to mesotrione on humans. Administration of mesotrione to volunteers resulted in an increase in plasma tyrosine concentrations, which reached a maximum of approximately 300 nmol/mL following a dose of 4 mg/kg body weight. Concentrations returned to background levels within 2 days of dosing. Urinary excretion of tyrosine metabolites was increased during the 24 hr immediately following a dose of 4 mg/kg, but returned to background levels during the following 24 hr period. Thus, the minimal and transient effects of mesotrione minimize the likelihood of a clinical effect in the event of systemic exposure occurring during occupational use. Mesotrione is not likely to be carcinogenic to humans. ANIMAL STUDIES: In animals, mesotrione is a mild Source: Hazardous Substances Data Bank (HSDB)

Environmental Bioconcentration: An estimated BCF of 3 was calculated for mesotrione(SRC), using a measured log Kow range of 0.90 at pH 5 to <-1.0 at pH 9(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)

Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), Koc values measured in 19 soils from the US and Europe ranging from 15 to 390(2,3), indicate that mesotrione is expected to have very high to moderate mobility in soil(SRC). Mesotrione is a weak acid with a pKa of 3.12(4) which indicates mesotrione will primarily exist in anion form in the environment and anions generally do not adsorb more strongly to organic carbon and clay than their neutral counterparts(5). The anionic form of mesotrione is a resonance enol-tautomer of the undissociated keto-tautomer(2). The Koc is inversely correlated with pH; as the pH increases, the Koc decreases(2,3). Volatilization of mesotrione from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of <1.2X10-10 atm-cu m/mole(SRC) derived from its vapor pressure, <4.27X10-8 mm Hg(6), and water solubility, 160 mg/L(6). Mesotrione is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure. The direct photolysis half-life on soil surfaces has been estimated to be 24 days at a latitude of 37-50 deg north(4). Degradation studies in active versus sterilized soils hav Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), Koc values measured in 19 soils from the US and Europe ranging from 15 to 390(2,3), indicate that mesotrione is not expected to adsorb to suspended solids and sediment(SRC). In water-sediment distribution tests, mesotrione was predominantly found in the water phase (>82%) with a maximum of 3.8% partitioning to sediment(4). Mesotrione is a weak acid with a pKa of 3.12(4) which indicates mesotrione will primarily exist in anion form in the environment and the anionic form of mesotrione is a resonance enol-tautomer of the undissociated keto-tautomer(2). Volatilization from water surfaces is not expected(5) based upon an estimated Henry's Law constant of <1.2X10-10 atm-cu m/mole(SRC), derived from its vapor pressure, <4.27X10-8 mm Hg(6), and water solubility, 160 mg/L(6). According to a classification scheme(7), an estimated BCF of 3(SRC), from its log Kow of 0.90 at pH 5(4) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low. Mesotrione is stable to hydrolysis at pH 4-9(4). Mesotrione is susceptible to direct photolysis in water with estimated half-lives of 81-97 days under sum Source: Hazardous Substances Data Bank (HSDB)
Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), mesotrione, which has a vapor pressure of <4.27X10-8 mm Hg at 20 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase mesotrione may be removed from the air by wet and dry deposition(SRC). Mesotrione absorbs at wavelengths >290 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)

Sources/Uses: Synthetic form of leptospermone (natural herbicide from the bottlebrush plant); Used as herbicide for maize; [Merck Index] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Industrial Processes with risk of exposure: Farming (Pesticides) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Uses: For mesotrione (USEPA/OPP Pesticide Code: 122990) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./ Source: Hazardous Substances Data Bank (HSDB)
Uses: Mesotrione is a selective herbicide registered for use to control broadleaf weeds in many agricultural and non-agricultural use sites. Source: Hazardous Substances Data Bank (HSDB)
Uses: Herbicide; For use on field corn, seed corn, sweet corn, yellow popcorn, and grain sorghum. Source: Hazardous Substances Data Bank (HSDB)
Uses: For pre-emergence and post-emergence control of broad-leaved weeds, such as Xanthium strumarium, Ambrosia trifida, Abutilon theophrasti, and Chenopodium, Amaranthus and Polygonum spp., and some grass weeds, in maize. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
EMBL-EBI ChEBI	Exact match	2026-08-31
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Mesotrione (ISO); 2-[4-(methylsulfonyl)- 2-nitrobenzoyl]-1,3- cyclohexanedione

Chemical / IUPAC name

Mesotrione (ISO); 2-[4-(methylsulfonyl)- 2-nitrobenzoyl]-1,3- cyclohexanedione

Regulatory information

Regulation

(EU) 2021/1902

See every entry this act set

Key data

CAS

104206-82-8

—

Annex

Entry number

1677

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1676