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Annex II Entry 1668 03/11/2021

2-methoxyethyl acrylate

2-methoxyethyl acrylate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1668

Chemical identity and properties

PubChem 2D chemical structure for CAS 3121-61-7
CAS 3121-61-7PubChem CID 18392

2-Methoxyethyl acrylate

2-methoxyethyl acrylate is a clear colorless liquid with a sharp musty odor. (NTP, 1992) — CAMEO Chemicals

IUPAC name
2-methoxyethyl prop-2-enoate
Molecular formula
C6H10O3
Molecular weight
130.14 g/mol
Exact mass
130.062994177 Da
XLogP3
0.3
Topological polar surface area
35.5 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

Methoxyethyl acrylate2-Propenoic acid, 2-methoxyethyl esterEthylene glycol methyl ether acrylateMethyl cellosolve acrylateEthylene glycol monomethyl ether acrylate2-Methoxyethanol, acrylateSipomer MCAAcrylic acid, 2-methoxyethyl ester
16 more reported names
Glycol monomethyl ether acrylateAcrylic acid, 2-methoxyethoxy esterEthanol, 2-methoxy-, acrylate2-Propenioc acid, 2-methoxyethyl esterNSC 24153Ageflex MEAEINECS 221-499-3BRN 1754333AI3-15726NSC-24153515K4I683YEC 221-499-3METHOXYETHYL ACRYLATE, 2-2-METHOXYETHYL 2-PROPENOATERefChem:474645SR 244
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

2-methoxyethyl acrylate

Chemical / IUPAC name

2-methoxyethyl acrylate

Regulatory information

Regulation

(EU) 2021/1902

See every entry this act set

Identified ingredients

Key data

CAS
3121-61-7
EC
221-499-3
Annex
II
Entry number
1668

Inventory links for 2-methoxyethyl acrylate

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for 2-methoxyethyl acrylate

2-methoxyethyl acrylate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 2-methoxyethyl acrylate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 3121-61-7 is the unique numerical identifier assigned to 2-methoxyethyl acrylate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 2-methoxyethyl acrylate

This page summarizes one Annex II record for 2-methoxyethyl acrylate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 2-methoxyethyl acrylate, but confirm any final regulatory decision against the current official annex wording and source files.

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