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Annex II Entry 1643 25/07/2022

4-Amino-3-hydroxytoluene when used as a substance in hair and eyelash dye products.

4-Amino-3-hydroxytoluene when used as a substance in hair and eyelash dye products. is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1643

Chemical identity and properties

PubChem 2D chemical structure for CAS 2835-98-5
CAS 2835-98-5PubChem CID 76082

2-Amino-5-methylphenol

The Expert Panel for Cosmetic Ingredient Safety concluded that the available data are insufficient to make a determination of safety for 6-Amino-m-Cresol under the intended conditions of use as a hair dye ingredient. — Cosmetic Ingredient Review (CIR)

IUPAC name
2-amino-5-methylphenol
Molecular formula
C7H9NO
Molecular weight
123.15 g/mol
Exact mass
123.068413911 Da
XLogP3
1.2
Topological polar surface area
46.3 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

6-Amino-m-cresol2-Hydroxy-4-methylanilinePhenol, 2-amino-5-methyl-4-Amino-3-hydroxytolueneQCG4ES2A26NSC-322874RefChem:85284220-620-7
16 more reported names
Cetilistat Impurity 46-Amino-3-methylphenol6-AMINO-3-CRESOLEINECS 220-620-72-hydroxy-4-methyl anilineOprea1_628116KSC-11-207-2EN300-208605-methyl-2-aminophenolUNII-QCG4ES2A26NSC 322874CCRIS 8309Cetilistat Impurity Am-Cresol, 6-amino-2-amino-5-methyl-phenol2-Amino-5-methyl phenol
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

4-Amino-3-hydroxytoluene when used as a substance in hair and eyelash dye products.

Chemical / IUPAC name

4-Amino-3-hydroxytoluene (*) when used as a substance in hair and eyelash dye products. (*) From 3 September 2021 hair and eyelash dye products containing those substances shall not be placed on the Union market. From 3 June 2022 hair and eyelash dye products containing those substances shall not be made available on the Union market.

Regulatory information

Regulation

(EU) 2020/1683

See every entry this act set

SCCS opinions

Identified ingredients

Key data

CAS
2835-98-5
EC
220-620-7
Annex
II
Entry number
1643

Inventory links for 4-Amino-3-hydroxytoluene when used as a substance in hair and eyelash dye products.

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1645
Nearby record in the same annex

Cobalt

CAS: 7440-48-4
EC: 231-158-0

What Annex II means for 4-Amino-3-hydroxytoluene when used as a substance in hair and eyelash dye products.

4-Amino-3-hydroxytoluene when used as a substance in hair and eyelash dye products. is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).

Frequently asked questions

Yes. 4-Amino-3-hydroxytoluene when used as a substance in hair and eyelash dye products. is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 2835-98-5 is the unique numerical identifier assigned to 4-Amino-3-hydroxytoluene when used as a substance in hair and eyelash dye products. by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 4-Amino-3-hydroxytoluene when used as a substance in hair and eyelash dye products.

This page summarizes one Annex II record for 4-Amino-3-hydroxytoluene when used as a substance in hair and eyelash dye products. from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 4-Amino-3-hydroxytoluene when used as a substance in hair and eyelash dye products., but confirm any final regulatory decision against the current official annex wording and source files.

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