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Annex II Entry 1636 CMR03/08/2020

Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts

Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1636
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 21049-39-8
CAS 21049-39-8PubChem CID 23701733

Sodium heptadecafluorononanoate

IUPAC name
sodium 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononanoate
Molecular formula
C9F17NaO2
Molecular weight
486.06 g/mol
Exact mass
485.9524523 Da
Topological polar surface area
40.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
19
Covalent units
2
Defined stereocentres
0

Also known as

RefChem:1113577sodium perfluorononanoatesodium;2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononanoateNonanoic acid, heptadecafluoro-, sodium saltC9F17NaO2
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 375-95-1
CAS 375-95-1PubChem CID 67821

Perfluorononanoic acid

Perfluorononanoic acid is a fluoroalkanoic acid that is nonanoic acid in which all of the hydrogens in the alkyl chain are replaced by fluorines. It has a role as a surfactant, a xenobiotic and a persistent organic pollutant. It is functionally related to a nonanoic acid. ChEBI

IUPAC name
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononanoic acid
Molecular formula
C9HF17O2
Molecular weight
464.08 g/mol
Exact mass
463.9705080 Da
XLogP3
5.6
Topological polar surface area
37.3 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
19
Covalent units
1
Defined stereocentres
0

Also known as

heptadecafluorononanoic acidPerfluoro-n-nonanoic acidHeptadecafluoropelargonic AcidPerfluorononan-1-oic acidPerfluornonansaeureHeptadecafluornonansaeureHeptadekafluornonansaeure5830Z6S63M
16 more reported names
Perfluorononanoic acid (PFNA)CHEBI:38397Nonanoic acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluoro-RefChem:860227PFNA perfluorononanoic acid21049-39-8 (Na salt)60871-92-3 (Li salt)21049-38-7 (K salt)4149-60-4 (NH4 salt)206-801-3PFNANonanoic acid, heptadecafluoro-PERFLUORONONANOICACIDPerfluoropelargonic AcidPFC; PFNAEINECS 206-801-3
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 4149-60-4
CAS 4149-60-4PubChem CID 160734

Ammonium perfluorononanoate

IUPAC name
azanium 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononanoate
Molecular formula
C9H4F17NO2
Molecular weight
481.11 g/mol
Exact mass
480.9970571 Da
Topological polar surface area
41.1 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
19
Covalent units
2
Defined stereocentres
0

Also known as

RefChem:557794Nonanoic acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluoro-, ammonium salt (1:1)Ammonium perfluoropelargonateNONANOICACID,HEXADECAFLUORO-,AMMONIUMSALTNonanoic acid, heptadecafluoro-, ammonium saltazanium;2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,9-heptadecafluorononanoateSurflon S-III-SAmmonium heptadecafluorononanoate
4 more reported names
EINECS 222-906-7Heptadecafluorononanoic acid ammonium saltMSK9504MPerfluorononan-1-oic-acid Ammonium Salt
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts

Chemical / IUPAC name

Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts

Regulatory information

Regulation

(EU) 2019/1966

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B

Key data

CAS
375-95-1 [1] / 21049-39-8 [2] / 4149-60-4 [3]
EC
206-801-3 [1] / - [2] / - [3]
Annex
Entry number
1636

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts

Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 375-95-1 [1] / 21049-39-8 [2] / 4149-60-4 [3] is the unique numerical identifier assigned to Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.

Source note for Annex II record Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts

This page summarizes one Annex II record for Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Perfluorononan-1-oic acid [1] and its sodium [2] and ammonium [3] salts, but confirm any final regulatory decision against the current official annex wording and source files.

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