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Annex II Entry 1593 CMR30/07/2020

2,3-Epoxypropyl methacrylate; glycidyl methacrylate

2,3-Epoxypropyl methacrylate; glycidyl methacrylate is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1593
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 106-91-2
CAS 106-91-2PubChem CID 7837

Glycidyl methacrylate

Glycidyl methacrylate is an enoate ester obtained by formal condensation of the carboxy group of methacrylic acid with the hydroxy group of glycidol. It is an epoxide and an enoate ester. It is functionally related to a methacrylic acid and a glycidol. — ChEBI

IUPAC name
oxiran-2-ylmethyl 2-methylprop-2-enoate
Molecular formula
C7H10O3
Molecular weight
142.15 g/mol
Exact mass
142.062994177 Da
XLogP3
0.8
Topological polar surface area
38.8 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

2,3-Epoxypropyl methacrylateGlycidol methacrylateSY-Monomer GBlemmer GAcriester GBlemmer GMALight Ester GMethacrylic acid, 2,3-epoxypropyl ester
16 more reported names
2-((Methacryloxy)methyl)oxirane2-Propenoic acid, 2-methyl-, oxiranylmethyl esterGlycidyl alpha-methylacrylateCP 105Glycidyl alpha-methyl acrylate1-Propanol, 2,3-epoxy-, methacrylateR8WN29J8VFSR 379NSC-241562-Propenoic acid, 2-methyl-, 2-oxiranylmethyl esterCHEBI:132844monomethacrylate propylene oxideRefChem:663607203-441-9oxiran-2-ylmethyl methacrylateglycidylmethacrylate
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:132844

glycidyl methacrylate

An enoate ester obtained by formal condensation of the carboxy group of methacrylic acid with the hydroxy group of glycidol.

Formula
C7H10O3
Average mass
142.154 g/mol
Monoisotopic mass
142.06299 Da
Formal charge
0
  • enoate ester — is a (CHEBI:51702)
  • epoxide — is a (CHEBI:32955)
  • methacrylic acid — has functional parent (CHEBI:25219)
  • glycidol — has functional parent (CHEBI:30966)
  • enoate ester — is a (CHEBI:51702)
  • epoxide — is a (CHEBI:32955)
Additional curated names
(oxiran-2-yl)methyl 2-methylprop-2-enoate2,3-Epoxypropanol methacrylate2,3-Epoxypropyl methacrylate2-((Methacryloxy)methyl)oxiraneGlycidol methacrylateGlycidyl alpha-methylacrylateMethacrylic acid, 2,3-epoxypropyl ester
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2017-01-27. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7837

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H360F: May damage fertility [Danger Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P319, P321, P330, P333+P317, P361+P364, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1165) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H302+H332 (37.9%): Harmful if swallowed or if inhaled [Warning Acute toxicity, oral; acute toxicity, inhalation]; H302 (98%): Harmful if swallowed [Warning Acute toxicity, oral]; H311 (74.8%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H312 (25.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H314 (22.3%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H315 (77.7%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (> 99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (22.2%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (77.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (81.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (17.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H341 (35.8%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350 (35.7%): May cause cancer [Danger Carcinogenicity]; H360 (27%): May damage fertility or the unborn child [Danger Reproductive toxicity]; H370 (19.8%): Ca Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P308+P316, P316, P317, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1165 reports by companies from 32 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 1165 reports by companies.; There are 31 notifications provided by 1164 of 1165 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P210, P260, P261, P262, P264, P264+P265, P270, P272, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P318, P319, P321, P330, P333+P317, P361+P364, P362+P364, P363, P370+P378, P403, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H227: Combustible liquid [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated for glycidyl methacrylate(SRC), using an estimated log Kow of 0.81(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that glycidyl methacrylate is expected to have very high mobility in soil(SRC). Volatilization of glycidyl methacrylate from moist soil surfaces is expected to occur slowly(SRC) given an estimated Henry's Law constant of 3.1X10-7 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Glycidyl methacrylate is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.62 mm Hg(SRC), determined from a fragment constant method(4). Screening tests indicate that glycidyl methacrylate is readily biodegradable; it reached 93-94% of its theoretical BOD in 4 weeks using an activated sludge inoculum(5). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that glycidyl methacrylate is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected to occur slowly(3) based upon an estimated Henry's Law constant of 3.1X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Volatilization half-lives for a model river and model lake are 140 days and 1000 days, respectively(SRC), using an estimation method(3). According to a classification scheme(5), an estimated BCF of 3(3), from an estimated log Kow of 0.81(6), suggests the potential for bioconcentration in aquatic organisms is low. A base-catalyzed second-order hydrolysis rate constant of 7X10-3 L/mole-sec(SRC) was estimated using a structure estimation method(7); this corresponds to half-lives of 31 yrs and 3 yrs at pH values of 7 and 8, respectively(7). The rate constant estimated for the epoxide does not include neutral hydrolysis rate constant. For some epoxides, the neutral rate constant is the dominant hydrolysis rate at environmental pHs. If the neutral Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), glycidyl methacrylate, which has an estimated vapor pressure of 0.62 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase glycidyl methacrylate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 17 hours(SRC) from its estimated rate constant of 3.1X10-7 cu cm/molecule-sec at 25 °C(3). Because the structurally similar ethyl methacrylate does not absorb light in the environmental spectrum above 290 nm(4), direct photolysis of glycidyl methacrylate is not expected to occur(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

2,3-Epoxypropyl methacrylate; glycidyl methacrylate

Chemical / IUPAC name

2,3-Epoxypropyl methacrylate; glycidyl methacrylate

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓—✓
Cat. 2—✓—

Key data

CAS
106-91-2
EC
203-441-9
Annex
II
Entry number
1593

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1589
Nearby record in the same annex

Imidazole

CAS: 288-32-4
EC: 206-019-2

What Annex II means for 2,3-Epoxypropyl methacrylate; glycidyl methacrylate

2,3-Epoxypropyl methacrylate; glycidyl methacrylate is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 2,3-Epoxypropyl methacrylate; glycidyl methacrylate is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 106-91-2 is the unique numerical identifier assigned to 2,3-Epoxypropyl methacrylate; glycidyl methacrylate by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

2,3-Epoxypropyl methacrylate; glycidyl methacrylate has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 2,3-Epoxypropyl methacrylate; glycidyl methacrylate

This page summarizes one Annex II record for 2,3-Epoxypropyl methacrylate; glycidyl methacrylate from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 2,3-Epoxypropyl methacrylate; glycidyl methacrylate, but confirm any final regulatory decision against the current official annex wording and source files.

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