Annex II
Entry 1537
CMR30/07/2020
N,N-(Dimethylamino)thioacetamide hydrochloride
N,N-(Dimethylamino)thioacetamide hydrochloride is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1537
CMR
Chemical identity and properties
CAS 27366-72-9PubChem CID 13121932
N,N-Dimethylaminothioacetamide hydrochloride
- IUPAC name
- 2-(dimethylamino)ethanethioamide;hydrochloride
- Molecular formula
- C4H11ClN2S
- Molecular weight
- 154.66 g/mol
- Exact mass
- 154.0331472 Da
- Topological polar surface area
- 61.4 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 2
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
2-(Dimethylamino)thioacetamide hydrochloride5O5XZB7AQCN,N-(Dimethylamino)thioacetamide hydrochlorideEC 435-470-1RefChem:822578435-470-12-(dimethylamino)ethanethioamide hydrochlorideDimethylaminothioacetamide hydrochloride
16 more reported names
2-(Dimethylamino)ethanethioamide xhydrochlorideC4H11ClN2SEthanethioamide, 2-(dimethylamino)-, monohydrochlorideNizatidine EP Impurity H2-(Dimethylamino)thioacetamide HCl(2-amino-2-sulfanylideneethyl)-dimethylazanium;chlorideUNII-5O5XZB7AQCDIMETHYLAMINOTHIOACETAMIDE HCL27366-72-9(HCl Salt)27366-72-9 (HCl Salt)CS-W021439GS-3475dimethylaminothioacetamide, hydrochlorideDB-0074302-(Dimethylamino)ethanethioamidexhydrochlorideEN300-66828
External database identifiers
- EPA DTXSID:DTXSID70950068
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
N,N-(Dimethylamino)thioacetamide hydrochloride
Chemical / IUPAC name
N,N-(Dimethylamino)thioacetamide hydrochloride
Regulatory information
CMR
| Category | Carcinogenic | Mutagenic | Reprotoxic |
|---|---|---|---|
| Cat. 1B | — | — | ✓ |
Key data
Related records for N,N-(Dimethylamino)thioacetamide hydrochloride
Direct matches are limited for this record, so nearby entries from Annex II are shown as well.
Annex II
1536
Nearby record in the same annex
Dimoxystrobin (ISO); (E)-2-(methoxyimino)-N-methyl-2-[a-(2,5-xylyloxy)-o-tolyl]acetamide
CAS: 149961-52-4
EC: 604-712-8
Annex II
1538
Nearby record in the same annex
Reaction mass of: 2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(2,4-dimethylphenyl)…
EC: 434-330-5
Annex II
1535
Nearby record in the same annex
N-[6,9-Dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6-oxo-1H-purin-2-yl]acetamide
CAS: 84245-12-5
EC: 424-550-1
Annex II
1539
Nearby record in the same annex
Petroleum, coal, tar and natural gas and their derivatives generated using distillation and/or othe…
CAS: 85536-20-5 [1]; 85536-19-2 [2]; 90641-12-6 [3]; 90989-38-1 [4]; 91995-20-9 [5]; 92062-36-7 [6]; 91995-61-8 [7]; 101316-63-6 [8]; 93821-38-6 [9]; 90641-02-4 [10]; 101316-62-5 [11]; 90641-03-5 [12]; 65996-79-4 [13]; 101794-90-5 [14]; 90640-87-2 [15]; 84650-03-3 [16]; 65996-82-9 [17]; 90641-01-3 [18]; 65996-87-4 [19]; 90640-99-6 [20]; 68391-11-7 [21]; 92062-33-4 [22]; 91082-52-9 [23]; 68937-63-3 [24]; 92062-28-7 [25]; 92062-27-6 [26]; 91082-53-0 [27]; 91995-31-2 [28]; 91995-35-6 [29]; 91995-66-3 [30]; 122070-79-5 [31]; 122070-80-8 [32]; 65996-78-3 [33]; 94114-52-0 [34]; 94114-53-1 [35]; 94114-54-2 [36]; 94114-56-4 [37]; 94114-57-5 [38]; 90641-11-5 [39]; 8006-61-9 [40]; 8030-30-6 [41]; 8032-32-4 [42]; 64741-41-9 [43]; 64741-42-0 [44]; 64741-46-4 [45]; 64742-89-8 [46]; 68410-05-9 [47]; 68514-15-8 [48]; 68606-11-1 [49]; 68783-12-0 [50]; 68921-08-4 [51]; 101631-20-3 [52]; 64741-64-6 [53]; 64741-65-7 [54]; 64741-66-8 [55]; 64741-70-4 [56]; 64741-84-0 [57]; 64741-92-0 [58]; 68410-71-9 [59]; 68425-35-4 [60]; 68527-27-5 [61]; 91995-53-8 [62]; 92045-49-3 [63]; 92045-55-1 [64]; 92045-58-4 [65]; 92045-64-2 [66]; 101316-67-0 [67]; 64741-54-4 [68]; 64741-55-5 [69]; 68476-46-0 [70]; 68783-09-5 [71]; 91995-50-5 [72]; 92045-50-6 [73]; 92045-59-5 [74]; 92128-94-4 [75]; 101794-97-2 [76]; 101896-28-0 [77]; 64741-63-5 [78]; 64741-68-0 [79]; 68475-79-6 [80]; 68476-47-1 [81]; 68478-15-9 [82]; 68513-03-1 [83]; 68513-63-3 [84]; 68514-79-4 [85]; 68919-37-9 [86]; 68955-35-1 [87]; 85116-58-1 [88]; 91995-18-5 [89]; 93571-75-6 [90]; 93572-29-3 [91]; 93572-35-1 [92]; 93572-36-2 [93]; 64741-74-8 [94]; 64741-83-9 [95]; 67891-79-6 [96]; 67891-80-9 [97]; 68425-29-6 [98]; 68475-70-7 [99]; 68603-00-9 [100]; 68603-01-0 [101]; 68603-03-2 [102]; 68955-29-3 [103]; 92045-65-3 [104]; 64742-48-9 [105]; 64742-49-0 [106]; 64742-73-0 [107]; 68410-96-8 [108]; 68410-97-9 [109]; 68410-98-0 [110]; 68512-78-7 [111]; 85116-60-5 [112]; 85116-61-6 [113]; 92045-51-7 [114]; 92045-52-8 [115]; 92045-57-3 [116]; 92045-61-9 [117]; 92062-15-2 [118]; 93165-55-0 [119]; 93763-33-8 [120]; 93763-34-9 [121]; 64741-47-5 [122]; 64741-48-6 [123]; 64741-69-1 [124]; 64741-78-2 [125]; 64741-87-3 [126]; 64742-15-0 [127]; 64742-22-9 [128]; 64742-23-0 [129]; 64742-66-1 [130]; 64742-83-2 [131]; 64742-95-6 [132]; 68131-49-7 [133]; 68477-34-9 [134]; 68477-50-9 [135]; 68477-53-2 [136]; 68477-55-4 [137]; 68477-61-2 [138]; 68477-89-4 [139]; 68478-12-6 [140]; 68478-16-0 [141]; 68513-02-0 [142]; 68516-20-1 [143]; 68527-21-9 [144]; 68527-22-0 [145]; 68527-23-1 [146]; 68527-26-4 [147]; 68603-08-7 [148]; 68606-10-0 [149]; 68783-66-4 [150]; 68919-39-1 [151]; 68921-09-5 [152]; 85116-59-2 [153]; 86290-81-5 [154]; 90989-42-7 [155]; 91995-38-9 [156]; 91995-41-4 [157]; 91995-68-5 [158]; 92045-53-9 [159]; 92045-60-8 [160]; 92045-62-0 [161]; 92045-63-1 [162]; 92201-97-3 [163]; 93165-19-6 [164]; 94114-03-1 [165]; 95009-23-7 [166]; 97926-43-7 [167]; 98219-46-6 [168]; 98219-47-7 [169]; 101316-56-7 [170]; 101316-66-9 [171]; 101316-76-1 [172]; 101795-01-1 [173]; 102110-14-5 [174]; 68476-50-6 [175]; 68476-55-1 [176]; 90989-39-2 [177];
EC: 287-502-5 [1]; 287-500-4 [2]; 292-636-2 [3]; 292-694-9 [4]; 295-281-1 [5]; 295-551-9 [6]; 295-323-9 [7]; 309-868-8 [8]; 298-725-2 [9]; 292-625-2 [10]; 309-867-2 [11]; 292-626-8 [12]; 266-013-0 [13]; 309-971-8 [14]; 292-609-5 [15]; 283-483-2 [16]; 266-016-7 [17]; 292-624-7 [18]; 266-021-4 [19]; 292-622-6 [20]; 269-929-9 [21]; 295-548-2 [22]; 293-766-2 [23]; 273-077-3 [24]; 295-543-5 [25]; 295-541-4 [26]; 293-767-8 [27]; 295-292-1 [28]; 295-295-8 [29]; 295-329-1 [30]; 310-170-0 [31]; 310-171-6 [32]; 266-012-5 [33]; 302-688-0 [34]; 302-689-6 [35]; 302-690-1 [36]; 302-692-2 [37]; 302-693-8 [38]; 292-635-7 [39]; 232-349-1 [40]; 232-443-2 [41]; 232-453-7 [42]; 265-041-0 [43]; 265-042-6 [44]; 265-046-8 [45]; 265-192-2 [46]; 270-077-5 [47]; 271-025-4 [48]; 271-727-0 [49]; 272-186-3 [50]; 272-931-2 [51]; 309-945-6 [52]; 265-066-7 [53]; 265-067-2 [54]; 265-068-8 [55]; 265-073-5 [56]; 265-086-6 [57]; 265-095-5 [58]; 270-088-5 [59]; 270-349-3 [60]; 271-267-0 [61]; 295-315-5 [62]; 295-430-0 [63]; 295-436-3 [64]; 295-440-5 [65]; 295-446-8 [66]; 309-871-4 [67]; 265-055-7 [68]; 265-056-2 [69]; 270-686-6 [70]; 272-185-8 [71]; 295-311-3 [72]; 295-431-6 [73]; 295-441-0 [74]; 295-794-0 [75]; 309-974-4 [76]; 309-987-5 [77]; 265-065-1 [78]; 265-070-9 [79]; 270-660-4 [80]; 270-687-1 [81]; 270-794-3 [82]; 270-993-5 [83]; 271-008-1 [84]; 271-058-4 [85]; 272-895-8 [86]; 273-271-8 [87]; 285-509-8 [88]; 295-279-0 [89]; 297-401-8 [90]; 297-458-9 [91]; 297-465-7 [92]; 297-466-2 [93]; 265-075-6 [94]; 265-085-0 [95]; 267-563-4 [96]; 267-565-5 [97]; 270-344-6 [98]; 270-658-3 [99]; 271-631-9 [100]; 271-632-4 [101]; 271-634-5 [102]; 273-266-0 [103]; 295-447-3 [104]; 265-150-3 [105]; 265-151-9 [106]; 265-178-6 [107]; 270-092-7 [108]; 270-093-2 [109]; 270-094-8 [110]; 270-988-8 [111]; 285-511-9 [112]; 285-512-4 [113]; 295-432-1 [114]; 295-433-7 [115]; 295-438-4 [116]; 295-443-1 [117]; 295-529-9 [118]; 296-942-7 [119]; 297-852-0 [120]; 297-853-6 [121]; 265-047-3 [122]; 265-048-9 [123]; 265-071-4 [124]; 265-079-8 [125]; 265-089-2 [126]; 265-115-2 [127]; 265-122-0 [128]; 265-123-6 [129]; 265-170-2 [130]; 265-187-5 [131]; 265-199-0 [132]; 268-618-5 [133]; 270-725-7 [134]; 270-735-1 [135]; 270-736-7 [136]; 270-738-8 [137]; 270-741-4 [138]; 270-771-8 [139]; 270-791-7 [140]; 270-795-9 [141]; 270-991-4 [142]; 271-138-9 [143]; 271-262-3 [144]; 271-263-9 [145]; 271-264-4 [146]; 271-266-5 [147]; 271-635-0 [148]; 271-726-5 [149]; 272-206-0 [150]; 272-896-3 [151]; 272-932-8 [152]; 285-510-3 [153]; 289-220-8 [154]; 292-698-0 [155]; 295-298-4 [156]; 295-302-4 [157]; 295-331-2 [158]; 295-434-2 [159]; 295-442-6 [160]; 295-444-7 [161]; 295-445-2 [162]; 296-028-8 [163]; 296-903-4 [164]; 302-639-3 [165]; 305-750-5 [166]; 308-261-5 [167]; 308-713-1 [168]; 308-714-7 [169]; 309-862-5 [170]; 309-870-9 [171]; 309-879-8 [172]; 309-976-5 [173]; 310-012-0 [174]; 270-690-8 [175]; 270-695-5 [176]; 292-695-4 [177];
Annex II
1534
Nearby record in the same annex
Cinidon ethyl (ISO); ethyl (Z)-2-chloro-3-[2-chloro-5-(cyclohex-1-ene-1,2-dicarboximido)phenyl]acry…
CAS: 142891-20-1
EC: 604-318-6
Annex II
1540
Nearby record in the same annex
Petroleum, coal, tar and natural gas and their derivatives generated using distillation and/or othe…
CAS: 90640-85-0 [1]; 92061-93-3 [2]; 90640-84-9 [3]; 61789-28-4 [4]; 70321-79-8 [5]; 122384-77-4 [6]; 70321-80-1 [7];
EC: 292-606-9 [1]; 295-506-3 [2]; 292-605-3 [3]; 263-047-8 [4]; 274-565-9 [5]; 310-189-4 [6]; 274-566-4 [7];
Annex II
1533
Nearby record in the same annex
4,4'-Methylenediphenyl diisocyanate; diphenylmethane-4,4'-diisocyanate [1]; 2,2'-Methylenediphenyl …
CAS: 101-68-8 [1] 2536-05-2 [2] 5873-54-1 [3] 26447-40-5 [4]
EC: 202-966-0 [1] 219-799-4 [2] 227-534-9 [3] 247-714-0 [4]
Annex II
1541
Nearby record in the same annex
Petroleum, coal, tar and natural gas and their derivatives generated using distillation and/or othe…
CAS: 85029-51-2 [1]; 84650-04-4 [2]; 84989-09-3 [3]; 91995-49-2 [4]; 121620-47-1 [5]; 121620-48-2 [6]; 90640-90-7 [7]; 90641-04-6 [8]; 101896-27-9 [9]; 101794-91-6 [10]; 91995-48-1 [11]; 90641-05-7 [12]; 84989-12-8 [13]; 121620-46-0 [14]; 90640-81-6 [15]; 90640-82-7 [16]; 92061-92-2 [17]; 91995-15-2 [18]; 91995-16-3 [19]; 91995-17-4 [20]; 101316-87-4 [21]; 122384-78-5 [22]; 84988-93-2 [23]; 90640-88-3 [24]; 65996-83-0 [25]; 90640-89-4 [26]; 90641-06-8 [27]; 65996-85-2 [28]; 101316-86-3 [29]; 92062-22-1 [30]; 96690-55-0 [31]; 84989-04-8 [32]; 84989-05-9 [33]; 84989-06-0 [34]; 84989-03-7 [35]; 84989-07-1 [36]; 68477-23-6 [37]; 68555-24-8 [38]; 91079-47-9 [39]; 92062-26-5 [40]; 94114-29-1 [41]; 90641-00-2 [42]; 68513-87-1 [43]; 70321-67-4 [44]; 92062-29-8 [45]; 100801-63-6 [46]; 100801-65-8 [47]; 100801-66-9 [48]; 73665-18-6 [49]; 68815-21-4 [50]; 65996-86-3 [51]; 65996-84-1 [52];
EC: 285-076-5 [1]; 283-484-8 [2]; 284-898-1 [3]; 295-310-8 [4]; 310-166-9 [5]; 310-167-4 [6]; 292-612-1 [7]; 292-627-3 [8]; 309-985-4 [9]; 309-972-3 [10]; 295-309-2 [11]; 292-628-9 [12]; 284-901-6 [13]; 310-165-3 [14]; 292-603-2 [15]; 292-604-8 [16]; 295-505-8 [17]; 295-275-9 [18]; 295-276-4 [19]; 295-278-5 [20]; 309-889-2 [21]; 310-191-5 [22]; 284-881-9 [23]; 292-610-0 [24]; 266-017-2 [25]; 292-611-6 [26]; 292-629-4 [27]; 266-019-3 [28]; 309-888-7 [29]; 295-536-7 [30]; 306-251-5 [31]; 284-892-9 [32]; 284-893-4 [33]; 284-895-5 [34]; 284-891-3 [35]; 284-896-0 [36]; 270-713-1 [37]; 271-418-0 [38]; 293-435-2 [39]; 295-540-9 [40]; 302-662-9 [41]; 292-623-1 [42]; 271-020-7 [43]; 274-560-1 [44]; 295-544-0 [45]; 309-745-9 [46]; 309-748-5 [47]; 309-749-0 [48]; 277-567-8 [49]; 272-361-4 [50]; 266-020-9 [51]; 266-018-8 [52];
Annex II
1532
Nearby record in the same annex
Trimethylopropane tri(3-aziridinylpropanoate); (TAZ)
CAS: 52234-82-9
EC: 257-765-0
Annex II
1542
Nearby record in the same annex
Petroleum, coal, tar and natural gas and their derivatives generated using distillation and/or othe…
CAS: 68607-11-4 [1]; 68783-06-2 [2]; 68814-67-5 [3]; 68814-90-4 [4]; 68911-58-0 [5]; 68911-59-1 [6]; 68919-01-7 [7]; 68919-02-8 [8]; 68919-03-9 [9]; 68919-04-0 [10]; 68919-07-3 [11]; 68919-08-4 [12]; 68919-11-9 [13]; 68919-12-0 [14]; 68952-79-4 [15]; 68952-80-7 [16]; 68955-33-9 [17]; 68989-88-8 [18]; 92045-15-3 [19]; 92045-16-4 [20]; 92045-17-5 [21]; 92045-18-6 [22]; 92045-19-7 [23]; 92045-20-0 [24]; 68131-75-9 [25]; 68307-98-2 [26]; 68307-99-3 [27]; 68308-00-9 [28]; 68308-01-0 [29]; 68308-10-1 [30]; 68308-03-2 [31]; 68308-04-3 [32]; 68308-05-4 [33]; 68308-06-5 [34]; 68308-07-6 [35]; 68308-09-8 [36]; 68308-11-2 [37]; 68308-12-3 [38]; 68409-99-4 [39]; 68475-57-0 [40]; 68475-58-1 [41]; 68475-59-2 [42]; 68475-60-5 [43]; 68476-26-6 [44]; 68476-29-9 [45]; 68476-40-4 [46]; 68476-42-6 [47]; 68476-49-3 [48]; 68476-85-7 [49]; 68476-86-8 [50]; 68477-33-8 [51]; 68477-35-0 [52]; 68477-69-0 [53]; 68477-70-3 [54]; 68477-71-4 [55]; 68477-72-5 [56]; 68308-08-7 [57];
EC: 271-750-6 [1]; 272-182-1 [2]; 272-338-9 [3]; 272-343-6 [4]; 272-775-5 [5]; 272-776-0 [6]; 272-873-8 [7]; 272-874-3 [8]; 272-875-9 [9]; 272-876-4 [10]; 272-880-6 [11]; 272-881-1 [12]; 272-884-8 [13]; 272-885-3 [14]; 273-173-5 [15]; 273-174-0 [16]; 273-269-7 [17]; 273-563-5 [18]; 295-397-2 [19]; 295-398-8 [20]; 295-399-3 [21]; 295-400-7 [22]; 295-401-2 [23]; 295-402-8 [24]; 268-629-5 [25]; 269-617-2 [26]; 269-618-8 [27]; 269-619-3 [28]; 269-620-9 [29]; 269-630-3 [30]; 269-623-5 [31]; 269-624-0 [32]; 269-625-6 [33]; 269-626-1 [34]; 269-627-7 [35]; 269-629-8 [36]; 269-631-9 [37]; 269-632-4 [38]; 270-071-2 [39]; 270-651-5 [40]; 270-652-0 [41]; 270-653-6 [42]; 270-654-1 [43]; 270-667-2 [44]; 270-670-9 [45]; 270-681-9 [46]; 270-682-4 [47]; 270-689-2 [48]; 270-704-2 [49]; 270-705-8 [50]; 270-724-1 [51]; 270-726-2 [52]; 270-750-3 [53]; 270-751-9 [54]; 270-752-4 [55]; 270-754-5 [56]; 269-628-2 [57];
Annex II
1531
Nearby record in the same annex
N,N',N''-Tris(2-methyl-2,3-epoxypropyl)-perhydro-2,4,6-oxo-1,3,5-triazine
CAS: 26157-73-3
EC: 435-010-8
Annex II
1543
Nearby record in the same annex
Tris[2-chloro-1-(chloromethyl)ethyl] phosphate
CAS: 13674-87-8
EC: 237-159-2
What Annex II means for N,N-(Dimethylamino)thioacetamide hydrochloride
N,N-(Dimethylamino)thioacetamide hydrochloride is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
- This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.
Frequently asked questions
Yes. N,N-(Dimethylamino)thioacetamide hydrochloride is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.
CAS 27366-72-9 is the unique numerical identifier assigned to N,N-(Dimethylamino)thioacetamide hydrochloride by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.
N,N-(Dimethylamino)thioacetamide hydrochloride has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.
Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
Source note for Annex II record N,N-(Dimethylamino)thioacetamide hydrochloride
This page summarizes one Annex II record for N,N-(Dimethylamino)thioacetamide hydrochloride from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for N,N-(Dimethylamino)thioacetamide hydrochloride, but confirm any final regulatory decision against the current official annex wording and source files.
Tools & next steps
Check your formula
Paste a full INCI list to detect N,N-(Dimethylamino)thioacetamide hydrochloride and other flagged EU annex records in one pass.
INCI CheckerCompare entries
Compare N,N-(Dimethylamino)thioacetamide hydrochloride side by side with another annex record to review differences in restrictions, concentrations and annex placement.
CompareBrowse the annex
See all records in Annex II and compare regulatory conditions across substances in this annex.
Open Annex II