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Annex II Entry 1527 CMR30/07/2020

Quinoline

Quinoline is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1527
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 91-22-5
CAS 91-22-5PubChem CID 7047

Quinoline

Quinoline is the simplest member of the quinoline class of compounds, comprising a benzene ring ortho fused to C-2 and C-3 of a pyridine ring. It is a member of quinolines, a mancude organic heterobicyclic parent, an azaarene and an ortho-fused heteroarene. — ChEBI

IUPAC name
quinoline
Molecular formula
C9H7N
Molecular weight
129.16 g/mol
Exact mass
129.057849228 Da
XLogP3
2.0
Topological polar surface area
12.9 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

1-BenzazineChinolineChinoleineChinolinQuinolin1-AzanaphthaleneLeucolLeukol
16 more reported names
Benzopyridine2,3-BenzopyridineBenzo[b]pyridineBenzo(b)pyridineUSAF EK-2181-BenzineFEMA No. 3470B 500AI3-01241B-500CHEBI:17362NSC-3396RefChem:6194202-051-6Quinoline-3-DQuinoline-4-D
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

Quinoline

Chemical / IUPAC name

Quinoline

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 1B✓——
Cat. 2—✓—

Key data

CAS
91-22-5
EC
202-051-6
Annex
II
Entry number
1527

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

What Annex II means for Quinoline

Quinoline is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. Quinoline is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 91-22-5 is the unique numerical identifier assigned to Quinoline by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

Quinoline has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record Quinoline

This page summarizes one Annex II record for Quinoline from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for Quinoline, but confirm any final regulatory decision against the current official annex wording and source files.

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