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Annex II Entry 1469 CMR30/07/2020

1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide

1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.

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Prohibited substance— Annex II, EU Regulation 1223/2009
Entry: 1469
CMR

Chemical identity and properties

PubChem 2D chemical structure for CAS 106-87-6
CAS 106-87-6PubChem CID 7833

Vinyl cyclohexene dioxide

4-vinylcyclohexene dioxide is the diepoxide of 4-vinylcyclohexene. It has a role as a carcinogenic agent. — ChEBI

IUPAC name
3-(oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane
Molecular formula
C8H12O2
Molecular weight
140.18 g/mol
Exact mass
140.083729621 Da
XLogP3
0.8
Topological polar surface area
25.1 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

4-Vinylcyclohexene dioxide4-Vinyl-1-cyclohexene dioxide4-Vinylcyclohexene diepoxide4-Vinyl-1-cyclohexene diepoxideVINYLCYCLOHEXENE DIOXIDEVinyl cyclohexene diepoxide1-Vinyl-3-cyclohexene dioxideChissonox 206
16 more reported names
1-Ethyleneoxy-3,4-epoxycyclohexane7-Oxabicyclo[4.1.0]heptane, 3-oxiranyl-1-Epoxyethyl-3,4-epoxycyclohexaneUnox epoxide 2064-Vinyl-1,2-cyclohexene diepoxideChissonox 206 monomerVinylcyclohexene DiepoxideErla-2270Erla-2271CCRIS 278EP-2064-(Epoxyethyl)-7-oxabicyclo(4.1.0)heptane3-Oxiranyl-7-oxabicyclo(4.1.0)heptane4-(1,2-Epoxyethyl)-7-oxabicyclo(4.1.0)heptaneNSC 547523-(Epoxyethyl)-7-oxabicyclo(4.1.0)heptane
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:59001

4-vinylcyclohexene dioxide

The diepoxide of 4-vinylcyclohexene.

Formula
C8H12O2
Average mass
140.182 g/mol
Monoisotopic mass
140.08373 Da
Formal charge
0
  • epoxide — is a (CHEBI:32955)
  • carcinogenic agent — has role (CHEBI:50903)
  • carcinogenic agent — has role (CHEBI:50903)
  • epoxide — is a (CHEBI:32955)
Additional curated names
3-(oxiran-2-yl)-7-oxabicyclo[4.1.0]heptane1-Epoxyethyl-3,4-epoxycyclohexane1-Ethyleneoxy-3,4-epoxycyclohexane1-Vinyl-3-cyclohexene dioxide3-(1,2-Epoxyethyl)-7-oxabicyclo(4.1.0)heptane3-(Epoxyethyl)-7-oxabicyclo(4.1.0)heptane3-Oxiranyl-7-oxabicyclo(4.1.0)heptane4-(1,2-Epoxyethyl)-7-oxabicyclo(4.1.0)heptane4-(Epoxyethyl)-7-oxabicyclo(4.1.0)heptane4-Vinyl-1,2-cyclohexene diepoxide4-Vinyl-1-cyclohexene dioxide4-Vinylcyclohexene diepoxideVinyl cyclohexene diepoxideVinyl cyclohexene dioxide
Cross-references from this source
  • REGISTRY_NUMBER: 106071 — Reaxys
  • CAS: 106-87-6 — KEGG COMPOUND
  • CAS: 106-87-6 — ChemIDplus
  • MANUAL_X_REF: C19311 — KEGG COMPOUND

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2015-12-21. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7833

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water wash immediately - If this chemical contacts the skin, immediately wash the contaminated skin with water. If this chemical penetrates the clothing, immediately remove the clothing and wash the skin with water. If symptoms occur after washing, get medical attention immediately.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H350: May cause cancer [Danger Carcinogenicity]; H360F: May damage fertility [Danger Reproductive toxicity] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P203, P261, P264, P270, P271, P280, P301+P317, P304+P340, P316, P318, P321, P330, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301 (95.1%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (97.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H351 (95.1%): Suspected of causing cancer [Warning Carcinogenicity] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P203, P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P318, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 41 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H350: May cause cancer [Danger Carcinogenicity]; H360: May damage fertility or the unborn child [Danger Reproductive toxicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P271, P273, P280, P304+P340, P317, P318, P319, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H303: May be harmful if swallowed [Warning Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P203, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P316, P318, P319, P321, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Record details

Chemical name

1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide

Chemical / IUPAC name

1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide

Regulatory information

Regulation

(EU) 2019/831

See every entry this act set

CMR

CategoryCarcinogenicMutagenicReprotoxic
Cat. 2✓——

Key data

CAS
106-87-6
EC
203-437-7
Annex
II
Entry number
1469

Direct matches are limited for this record, so nearby entries from Annex II are shown as well.

Annex II 1463
Nearby record in the same annex

Dialuminium nickel tetraoxide [1]; Nickel titanium trioxide [2]; Nickel titanium oxide [3]; Nickel …

CAS: 12004-35-2 [1] / 12035-39-1 [2] / 12653-76-8 [3] / 52502-12-2 [4] / 68016-03-5 [5] / 70692-93-2 [6] / 14177-55-0 [7] / 14177-51-6 [8] / 68515-84-4 [9] / 12031-65-1 [10] / 12673-58-4 [11]
EC: 234-454-8 [1] / 234-825-4 [2] / 235-752-0 [3] / 257-970-5 [4] / 268-169-5 [5] / 274-755-1 [6] / 238-034-5 [7] / 238-032-4 [8] / 271-112-7 [9] / - [10] / - [11]

What Annex II means for 1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide

1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.

Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.

The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.

Compliance checklist

  • Verify this substance is absent from all raw materials and finished formulations.
  • Request absence confirmation or CoA from raw material suppliers.
  • Document the screening result in the Product Information File (PIF).
  • This substance has CMR classification. Review the CMR table above and verify current Annex II/III status before use.

Frequently asked questions

Yes. 1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide is listed in Annex II of EU Cosmetics Regulation 1223/2009 and is prohibited as an intentionally added cosmetic ingredient. Article 17 provides a narrow exception for unintended small quantities that are technically unavoidable under good manufacturing practice, provided the product remains safe under Article 3.

CAS 106-87-6 is the unique numerical identifier assigned to 1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide by the Chemical Abstracts Service. In cosmetic compliance work, the CAS number is used to cross-reference the substance across regulatory databases, raw material specifications and safety assessment reports. Multiple EU annex entries may share the same CAS number if the same substance appears under different conditions or in different annexes.

1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide has a CMR (carcinogenic, mutagenic or reprotoxic) classification under EU CLP Regulation. Under Article 15 of EU Cosmetics Regulation 1223/2009, CMR substances of category 1A or 1B are prohibited in cosmetics unless specifically permitted. Category 2 CMR substances may be used only if assessed safe by the SCCS. Always verify current annex status and any applicable derogations before use.

Use the INCI Checker tool on this site to paste your full ingredient list (INCI) and scan it against all Annex II–VI entries. The tool highlights any ingredients that match restricted, prohibited or allergen-flagged records. This is useful for rapid compliance screening of finished product formulas or raw material declarations.
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Source note for Annex II record 1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide

This page summarizes one Annex II record for 1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.

Use this record page to review Annex II conditions for 1,2-Epoxy-4-epoxyethylcyclohexane; 4-vinylcyclohexene diepoxide, but confirm any final regulatory decision against the current official annex wording and source files.

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