4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye products
4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye products is listed in Annex II as a prohibited substance for cosmetic products placed on the EU market.
Chemical identity and properties
4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole-sulfate
- IUPAC name
- bis(1-[(4-chlorophenyl)methyl]pyrazole-4,5-diamine);sulfuric acid
- Molecular formula
- C20H24Cl2N8O4S
- Molecular weight
- 543.4 g/mol
- Exact mass
- 542.1018278 Da
- Topological polar surface area
- 223.0 Ų
- Hydrogen-bond donors
- 6
- Hydrogen-bond acceptors
- 10
- Covalent units
- 3
- Defined stereocentres
- 0
Also known as
2 more reported names
External database identifiers
- EPA DTXSID:DTXSID90892456
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Record details
Chemical name
4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye products
Regulatory information
SCCS opinions
- Opinion concerning Use of Permanent Hair Dyes and Bladder Cancer - Updated 2004
- Opinion concerning Hair Dyes without File submitted
- Opinion on Personal Use of Hair Dyes and Cancer Risk
- Opinion on the Use of Permanent Hair Dyes and Bladder Cancer Risk
- Assessment Strategies for Hair Dyes
Identified ingredients
Key data
Inventory links for 4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye products
4,5-DIAMINO-1-((4-CHLOROPHENYL)METHYL)-1H-PYRAZOLE-SULFATE
Related records for 4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye products
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What Annex II means for 4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye products
4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye products is listed as a prohibited substance under Annex II of EU Cosmetics Regulation 1223/2009 and must not be intentionally added. Article 17 separately addresses unintended small quantities that are technically unavoidable under good manufacturing practice and compatible with the Article 3 safety requirement.
Formulators must screen their ingredients and raw materials to ensure none contain this substance. Suppliers should provide documentation confirming absence when requested.
This record is linked to 1 CosIng inventory ingredient for name and identifier cross-reference. The page also surfaces 12 related annex records with overlapping identifiers, annex logic or naming patterns.
Compliance checklist
- Verify this substance is absent from all raw materials and finished formulations.
- Request absence confirmation or CoA from raw material suppliers.
- Document the screening result in the Product Information File (PIF).
Frequently asked questions
Source note for Annex II record 4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye products
This page summarizes one Annex II record for 4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye products from public European Commission cosmetic materials and adds linked inventory or identifier matches when available.
Use this record page to review Annex II conditions for 4,5-Diamino-1-((4-chlorophenyl)methyl)-1H-pyrazole sulfate, when used as a substance in hair dye products, but confirm any final regulatory decision against the current official annex wording and source files.
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