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Official EU label nameGlossary entry 23226

P-PHENYLENEDIAMINE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 7 of 13 indexed market datasets: 12 country records and 0 EU Annex records. Every result and evidence gap is listed below.

7 markets with evidence
Markets checked
13
Markets with evidence
7
Evidence gaps
6
Resolved identifiers
6

A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.

Resolved substance identity

CAS:106-50-3624-18-016245-77-5
EC:203-404-7210-834-9240-357-1
Ingredient index records:
P-PHENYLENEDIAMINE
Cosmetic functions: HAIR DYEING

Benzene-1,4-diamine

Inventory restriction note: III/8a

Open full local profile
11 matched or reported names
P-PHENYLENEDIAMINEp-Phenylenediamine;p-Phenylenediamine HCl;p-Phenylenediamine Sulphatep -Phenylenediamine and its saltsp-Phenylenediamine and its salts e.g. p-phenylenediaminep-Phenylenediamine and its salts p-Phenylenediamine; p-Phenylenediamine HCl; p-Phenylenediamine Sulphate CAS No 106-50-3 / 624-18-0 / 16245- 77-5p-페닐렌디아민1)p-페닐렌디아민a) -Phenylenediamine p and its salts -Phenylenediamine p (CAS No. 106-50-3) -Phenylenediamine HCl p (CAS No. 624-18-0) -Phenylenediamine p Sulphate (CAS No. 16245-77-5)b)p-Phenylenediamine and its salts p- Phenylene- diamine (CAS No. 106-50-3) p-Phenylenedia- mine HCl (CAS No. 624-18-0) p-Phenylenedia- mine sulphate (CAS No. 16245-77-5)p-Phenylenediamine and its saltsp- Phenylene-diamine and its salts

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

Swipe or scroll horizontally to see dataset coverage and next actions.

MarketResultRecordsDatasetMeaning / next action
European Union
EU
No local match0
Complete annex dataset
Regulation (EC) 1223/2009 consolidated to 1 May 2026
No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain
GB
Restricted2Open record 1Open record 2
Complete consolidated annex dataset
GB retained Regulation 1223/2009 schedules, effective 15 August 2026
Review every linked record and exact conditions.
Canada
CA
Restricted1Open record 1
Complete Hotlist snapshot
Health Canada Cosmetic Ingredient Hotlist, 13 August 2025
Review every linked record and exact conditions.
New Zealand
NZ
Restricted2Open record 1Open record 2
Complete schedules dataset
Cosmetic Products Group Standard schedules effective 1 January 2026
Review every linked record and exact conditions.
ASEAN
ASEAN
Restricted1Open record 1
Complete regional annex dataset
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Review every linked record and exact conditions.
China
CN
No local match0
Complete prohibited catalogues plus official-source workflow
NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025
IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan
JP
No local match0
Complete Standards appendices dataset
MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot
The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea
KR
Prohibited2Open record 1Open record 2
Complete current appendix dataset
MFDS Notice 2026-19, effective 18 March 2026
Review every linked record and exact conditions.
United States
US
No local match0
Complete enumerated federal ingredient rules
eCFR Title 21 issue date 27 August 2026
FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia
AU
No local match0
Complete cosmetic-relevant Poisons Standard subset plus official workflow
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026
An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil
BR
No local match0
Complete prohibited dataset plus current restricted-list workflow
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026
RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India
IN
Restricted2Open record 1Open record 2
Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
Review every linked record and exact conditions.
Saudi Arabia
SA
Restricted2Open record 1Open record 2
Complete official list index
SFDA live prohibited/restricted lists, snapshot 30 August 2026
Review every linked record and exact conditions.
No market rows match this filter.

Matching market records and conditions

Great Britain

GB retained Regulation 1223/2009 schedules, effective 15 August 2026
p-Phenylenediamine;p-Phenylenediamine HCl;p-Phenylenediamine SulphateRestricted
Hair dye substance in oxidative hair dye products · (a) General use · (a) To be printed on the label: The mixing ratio. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “ black henna ” tattoos may increase your risk of …
GB Cosmetics Regulation, Annex III, entry 8a · 2026-08-15
p-Phenylenediamine;p-Phenylenediamine HCl;p-Phenylenediamine SulphateRestricted
Products intended for colouring eyelashes · After mixing under oxidative conditions the maximum concentration applied to eyelashes must not exceed 2% calculated as free base For professional use only. · To be printed on the label: The mixing ratio. For professional use only. Thi…
GB Cosmetics Regulation, Annex III, entry 8b · 2026-08-15

New Zealand

Cosmetic Products Group Standard schedules effective 1 January 2026
p-Phenylenediamine and its salts e.g. p-phenylenediamineRestricted
Product scope: Hair dye substance in oxidative hair dye products: (a) General use (b) Professional use · Maximum concentration: (a) and (b): After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2% calculated as free base · Warnings: F…
Schedule 5, reference 8a, source row 14 · effective-2026-01-01
p-Phenylenediamine and its salts e.g. p-phenylenediamineRestricted
Product scope: Products intended for colouring eyelashes · Maximum concentration: After mixing under oxidative conditions the maximum concentration applied to eyelashes must not exceed 2% calculated as free base · Other limitations: For professional use only · Warnings: The mixi…
Schedule 5, reference 8b, source row 17 · effective-2026-01-01

ASEAN

ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
p-Phenylenediamine and its salts p-Phenylenediamine; p-Phenylenediamine HCl; p-Phenylenediamine Sulphate CAS No 106-50-3 / 624-18-0 / 16245- 77-5Restricted
Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2 % calculated as free base The direction for use “wear suitable gloves” …
ASEAN Annex III, reference 8a · 2026-1

India

Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
a) -Phenylenediamine p and its salts -Phenylenediamine p (CAS No. 106-50-3) -Phenylenediamine HCl p (CAS No. 624-18-0) -Phenylenediamine p Sulphate (CAS No. 16245-77-5)Restricted
Field of application/use: Hair dye substance in oxidative hair dye products | Other limitations/requirements: a)General use b)Professional use For (a) and (b): After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2 percent calculated …
IS 4707 (Part 2):2025 Annex B, entry 8a · IS 4707 (Part 2):2025, fifth revision
b)p-Phenylenediamine and its salts p- Phenylene- diamine (CAS No. 106-50-3) p-Phenylenedia- mine HCl (CAS No. 624-18-0) p-Phenylenedia- mine sulphate (CAS No. 16245-77-5)Restricted
Field of application/use: Products intended for coloring eyelashes. | Other limitations/requirements: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2 percent calculated as free base For professional use only. | Label conditions…
IS 4707 (Part 2):2025 Annex B, entry 8b · IS 4707 (Part 2):2025, fifth revision

Chemical identity and properties

PubChem 2D chemical structure for CAS 106-50-3
CAS 106-50-3PubChem CID 7814

P-Phenylenediamine

1,4-phenylenediamine is a phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus. It has a role as a reagent, a dye, an allergen and a hapten. — ChEBI

IUPAC name
benzene-1,4-diamine
Molecular formula
C6H8N2
Molecular weight
108.14 g/mol
Exact mass
108.068748264 Da
XLogP3
-0.3
Topological polar surface area
52.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

1,4-BENZENEDIAMINE1,4-Diaminobenzene1,4-Phenylenediamine4-Aminoanilinepara-phenylenediaminep-Aminoanilinep-DiaminobenzeneOrsin
16 more reported names
ParaphenylenediamineUrsol D4-Phenylenediaminep-BenzenediamineFouramine DFutramine DBenzofur DDeveloper PFFourrine DFur YellowSantoflex ICSantoflex LCDurafur Black RPelagol DTertral DPelagol DR
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:51403

1,4-phenylenediamine

A phenylenediamine in which the amino functions are at positions 1 and 4 of the benzene nucleus.

Formula
C6H8N2
Average mass
108.144 g/mol
Monoisotopic mass
108.06875 Da
Formal charge
0
  • phenylenediamine — is a (CHEBI:51402)
  • dye — has role (CHEBI:37958)
  • reagent — has role (CHEBI:33893)
  • allergen — has role (CHEBI:50904)
  • hapten — has role (CHEBI:59174)
  • dye — has role (CHEBI:37958)
  • reagent — has role (CHEBI:33893)
  • allergen — has role (CHEBI:50904)
  • hapten — has role (CHEBI:59174)
  • phenylenediamine — is a (CHEBI:51402)
Additional curated names
benzene-1,4-diamine1,4-Benzenediamine1,4-diaminobenzene4-Aminoaniline4-phenylenediaminepara-phenylenediamineparaphenylene-diamineparaphenylenediaminep-DiaminobenzenePPDpPDAPPDAp-Phenylenediaminep-phenylenediamine base
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2024-03-05. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7814

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P321, P330, P333+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301+H311+H331 (43.2%): Toxic if swallowed, in contact with skin or if inhaled [Danger Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]; H301 (99.7%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (99.7%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H317 (99.8%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (99.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331 (99.7%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H370 (38.9%): Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H400 (98.3%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (99.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P260, P261, P262, P264, P264+P265, P270, P271, P272, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P321, P330, P333+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 597 reports by companies from 32 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P233, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P319, P321, P330, P333+P317, P337+P317, P342+P316, P362+P364, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P233, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P302+P352, P304+P340, P305+P351+P338, P308+P316, P316, P319, P321, P330, P332+P317, P333+P317, P337+P317, P342+P316, P362+P364, P391, P403, P403+P233, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Environmental Bioconcentration: An estimated BCF value of 0.3 was calculated for 1,4-benzenediamine(SRC), using a measured log Kow of -0.3(1,SRC) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). An experimental BCF value of 450 was measured for algae exposed to 1,4-diaminobenzene dihydrochloride for 24 hours(4). An experimental BCF value of 6 was measured for fish (golden ide) exposed to 1,4-diaminobenzene dihydrochloride for 3 days(4). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 16(SRC), determined from a measured log Kow of -0.30(2), and a recommended regression-derived equation(3), indicates that 1,4-benzenediamine is expected to have high mobility in soil(SRC); however it may form covalent bonds to humic material which would limit movement through soil(4). Volatilization of 1,4-benzenediamine is not expected from moist soil surfaces(SRC) given an estimated Henry's Law constant of 6.7X10-10 atm-cu m/mole(SRC), using a fragment constant estimation method(5). Volatilization of 1,4-benzenediamine from dry soil surfaces is not expected(SRC) based on an extrapolated vapor pressure of 0.005 mm Hg(SRC) at 25 °C(6). Biodegradation is expected to occur slowly in soils based on standard biodegradability tests conducted with activated sludge(7-11). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 16(SRC), determined from a measured log Kow of -0.30(2), and a recommended regression-derived equation(3), indicates that 1,4-benzenediamine is not expected to adsorb to suspended solids and sediment in water(SRC). 1,4-benzenediamine is not expected to volatilize from water surfaces(3,SRC) based on an estimated Henry's Law constant of 6.7X10-10 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). Degradation of 1,4-benzenediamine by photochemically produced peroxy radicals will be an important environmental fate process in surface waters(5,SRC). The half-life of this reaction is estimated as 1 day for a solution concentration of 1X10-9 M of peroxy radicals and an estimated rate constant of 1X10+4 L/mol-s(5). According to a classification scheme(6), an estimated BCF value of 0.3(3,SRC), from a measured log Kow of -0.3(2,SRC), suggests that bioconcentration in aquatic organisms is low(SRC). Biodegradation in aquatic environments is not expected to be an important environmental fate process(SRC). A 0% theoretical oxygen demand was observed for 1,4-benzenediamine in a Warbu Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,4-benzenediamine, which has an extrapolated vapor pressure of 0.005 mm Hg at 25 °C(2,SRC), is expected to exist primarily as a vapor in the ambient atmosphere. Vapor-phase 1,4-benzenediamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be about 2 hours(3,SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Link: CIR ingredient: p-Phenylenediamine Source: Cosmetic Ingredient Review (CIR)
  • Uses: p-Phenylenediamine is primarily used as a dye intermediate and as a dye (e.g., hair dyes and dyes used for dyeing furs), as well as a photographic developing agent and a chemical intermediate. p-Phenylenediamine is also used as a vulcanization accelerator and as an antioxidant in rubber compounds. Source: EPA Hazardous Air Pollutants
  • Sources/Uses: Used to dye hair and fur; also used to develop photographs and to synthesize other organic compounds; [ACGIH] Occupational asthma reported in fur dyers; [Malo] Allergic contact dermatitis in hairdressers, mechanics, printers, and textile workers; [Marks] Used to dye leather; [PMID 21938525] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Leather Tanning and Processing [Category: Industry]; Photographic Processing [Category: Other]; Fur Dressing and Dyeing [Category: Industry]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry]; Dressing Hair [Category: Other] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Dyeing furs; also in photochemical measurements, accelerating vulcanization; manuf azo dyes. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: CHEM INT FOR DYES (EG, DIRECT BLACK 19, 78 & 80); OXIDN BASE 10 & DEVELOPER 13 FOR DYES; CHEM INT FOR ARAMID FIBERS (USED IN TIRE CORD); CHEM INT FOR N,N'-DISUBSTITUTED-P-PHENYLENEDIAMINES; COMPONENT OF GASOLINE ANTIOXIDANTS. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used as an intermediate for the manufacture of diisocyanates for polyurethane Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Substance listed with specific concentration in tattoo ink and/or permanent make up according to EU Commission Regulation 2020/2081. The concentration limit (by weight) is 0.0005%. Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 16245-77-5
CAS 16245-77-5PubChem CID 27769

1,4-Benzenediamine sulfate

IUPAC name
benzene-1,4-diamine;sulfuric acid
Molecular formula
C6H10N2O4S
Molecular weight
206.22 g/mol
Exact mass
206.03612798 Da
Topological polar surface area
135.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
6
Covalent units
2
Defined stereocentres
0

Also known as

p-Phenylenediamine sulfate1,4-Benzenediamine, sulfate (1:1)1,4-Benzenediamine, sulfateUNII-S7IGM30961HSDB 6256EINECS 240-357-1COVASTYLE PPDSCOLOREX PPDS
16 more reported names
1,4-Benzenediamine sulfate (1:1)1,4-BENZENEDIAMINE SULFATE [HSDB]pPhenylenediamine sulfateRefChem:73044Benzene1,4diammonium sulphateP-PHENYLENEDIAMINE SULFATE [INCI]240-357-11,4-Phenylenediamine Sulfate1,4-Diaminobenzene SulfateBenzene-1,4-diammonium sulphateS7IGM30961UFPKLWVNKAMAPE-UHFFFAOYSA-NBS-42135DB-043524DB-071285P0175
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 624-18-0
CAS 624-18-0PubChem CID 12205

1,4-Diaminobenzene dihydrochloride

IUPAC name
benzene-1,4-diamine;dihydrochloride
Molecular formula
C6H10Cl2N2
Molecular weight
181.06 g/mol
Exact mass
180.0221037 Da
Topological polar surface area
52.0 Ų
Hydrogen-bond donors
4
Hydrogen-bond acceptors
2
Covalent units
3
Defined stereocentres
0

Also known as

p-Phenylenediamine dihydrochloride1,4-Phenylenediamine dihydrochloridebenzene-1,4-diamine dihydrochlorideFourrine DSPelagol Grey CDDurafur Black RCFourrine 641,4-Benzenediamine dihydrochloride
16 more reported names
p-PD HClp-Phenylenediamine HClPelagol CD1,4-Benzenediamine, dihydrochloridep-Pda HClOxidation Base 10AC.I. Oxidation Base 10A4-Aminoaniline dihydrochloridep-Benzenediamine dihydrochloridep-Diaminobenzene dihydrochlorideCI Oxidation Base 10ANCI-C03930p-Phenylenediamine, dihydrochloridep-Aminoaniline dihydrochlorideCCRIS 510Phenylenediamine dihydrochloride
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

These source-specific lookups can add hazard, toxicology, identity and assessment context. A link is a research route, not a claim that the source contains an exact record.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

Research this identity

FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

Research this identity

ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

Research this identity

Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

Research this identity

NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

Research this identity

OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

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Continue the compliance check

1. Confirm identity

Match the supplier specification, CAS/EC identifiers and composition to this official label name. Similar wording is not proof of chemical equivalence.

2. Review restrictions

Check every exact Annex record shown above, plus CMR, nanomaterial, SCCS and later-amendment requirements that may apply.

3. Verify the formula

Evaluate concentration, product type, purity, warnings, claims and each target market before making a compliance decision.

Screen in a formulaOpen standalone comparison

Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

Open official Decision